Abstract: A method of improving the data quality in spatial frequency spectra by acquiring a prism acquisition consisting of echo data that is one or more repetitions of a one-dimensional frequency encoded signal along the length of one or more prism volumes, placed within a sample of a structure to be studied, generating prism profiles from the echo data, and correcting for motion during the acquisition by calculating motion having occurred during the prism acquisition from assessment of the prism profiles for the multiple repetitions, or by indicating a region of sample of structure to be studied on a reference image, using this to segment a map of features in the prism profiles and shifting the location of this region to correct for motion having occurred between the acquisition of the reference image and the prism acquisition.

Abstract: The disclosed invention is a method for detecting indications of the presence of Alzheimer's disease (AD) and related dementia-inducing, motor-control-related pathologies, and other diseases in the human brain using a magnetic-resonance based technique for measuring fine tissue and bone textures. Specifically, the invention focuses on refinements/adaptations to a prior art magnetic resonance fine texture measurement technique that facilitates/enables pushing the detection limits closer to the cellular level, so as to be able to measure the fine scale structures and tissue changes that are known to be characteristic of the neurodegenerative processes involved in the development of these diseases.