Abstract: A system and method for adjusting a catheter to create a medicated atmosphere in an organ, or body cavity is disclosed. The system comprises a catheter, such as an aerosolization catheter, that can be manipulated during use and an introduction device for the introduction and manipulation, by rotational and/or axial positioning, of the aerosolization catheter. The method includes inserting the catheter into a body cavity via an introducer apparatus and adjusting an angle or orientation of the exit end of the catheter so that a substance provided to the catheter will be controllably applied to the body cavity at desired locations.