Patents by Inventor J. Michael Pierce

J. Michael Pierce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11623953
    Abstract: Provided herein are antibodies and related polypeptides that bind specifically to CEACAM6. The antibodies and/or polypeptides can be configured as bispecific T cell engagers. The antibodies and/or polypeptides can also be configured as chimeric antigen receptors. Also provided are methods of detection and treatment of cancer, for example, pancreatic cancer, using the antibodies and related polypeptides herein.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: April 11, 2023
    Assignees: Caerus Therapeutics, Inc., University of Georgia Research Foundation, Inc.
    Inventors: J. Michael Pierce, Cohava Gelber
  • Publication number: 20210371516
    Abstract: Provided herein are antibodies and related polypeptides that bind specifically to CEACAM6. The antibodies and/or polypeptides can be configured as bispecific T cell engagers. The antibodies and/or polypeptides can also be configured as chimeric antigen receptors. Also provided are methods of detection and treatment of cancer, for example, pancreatic cancer, using the antibodies and related polypeptides herein.
    Type: Application
    Filed: February 27, 2018
    Publication date: December 2, 2021
    Applicants: CAERUS THERAPEUTICS, INC., UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: J. Michael PIERCE, Cohava GELBER
  • Publication number: 20110136147
    Abstract: Novel methods to identify and characterize glycoproteins that are likely to be found in serum, and that will therefore provide more relevant disease markers than current methods are disclosed. The proteins that are likely to be found in serum are distinguished either by cleavage from the membrane or as potentially secreted proteins characterized by solubility in an aqueous phase. The methods disclosed also allow determination of differential glycosylation patterns of proteins that are likely to be found in serum from cells in various stages of disease. In addition, methods to identify novel therapeutic targets by identifying glycoproteins retained in diseased cells are disclosed.
    Type: Application
    Filed: September 7, 2005
    Publication date: June 9, 2011
    Inventor: J. Michael Pierce
  • Patent number: 7351544
    Abstract: Methods are disclosed for identifying oligosaccharides found on proteins and identifying those that are modified in disease states.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: April 1, 2008
    Assignee: The University of Georgia Research Foundation, Inc.
    Inventor: J. Michael Pierce
  • Patent number: 7008592
    Abstract: Decontamination is achieved by producing an activated cleaning fluid mist using a decontamination apparatus having a source of a cleaning fluid, a mist generator having an input flow of the cleaning fluid and an output flow of a mist of the cleaning fluid at substantially one atmosphere ambient pressure, and an activator positioned to activate the mist of the cleaning fluid to produce the activated cleaning fluid mist wherein atoms of the cleaning fluid are activated. The activated cleaning fluid mist is contacted to a location to be decontaminated.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: March 7, 2006
    Assignee: Intecon Systems, Inc.
    Inventors: Ralph M. Sias, Heath E. Sias, Stanley J. Diniz, Fernando Guerrero, J. Michael Pierce, Louis Montulli
  • Patent number: 6969487
    Abstract: A biochemical agent is denatured by producing an activated cleaning fluid mist containing activated hydroxyl species wherein at least a portion of the activated cleaning fluid mist is in an activated state at substantially one atmospheric ambient pressure, and contacting the activated cleaning fluid mist to a biochemical agent.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: November 29, 2005
    Assignee: Intecon Systems, Inc.
    Inventors: Ralph M. Sias, Heath E. Sias, J. Michael Pierce, Louis Montulli
  • Patent number: 6767728
    Abstract: A method and composition for deinking noncontact-printed wastepaper, particularly xerographic and laser-printed paper, and mixtures of contact and noncontact-printed wastepaper, using an enzyme mixture characterized by a high ratio of &bgr;-glucosidase activity to filter paper units (FPU) activity. The present invention also relates to an assay for evaluating enzymes for use in deinking wastepaper based on the ratio of &bgr;-glucosidase activity to FPU activity.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: July 27, 2004
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Jan L. Yang, Jiahua Ma, J. Michael Pierce, Karl-Erik L Eriksson
  • Patent number: 6524820
    Abstract: The present disclosure provides a novel family of C-type lectins from vertebrates. As specifically exemplified, this family of lectins includes a melibiose-specific lectin (XL35) from Xenopus laevis oocytes, and two human lectins, HL-3 and HL-13, specifically expressed in endothelial cells such as blood vessels, stomach, small intestine, heart and tissue and in small intestine, respectively. Amino acid sequences of the lectin proteins are provided herein, together with the nucleotide sequences encoding these proteins.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: February 25, 2003
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: J. Michael Pierce, Kelley W. Moremen, Jin Kyu Lee
  • Publication number: 20030035754
    Abstract: Decontamination is achieved by producing an activated cleaning fluid mist using a decontamination apparatus having a source of a cleaning fluid, a mist generator having an input flow of the cleaning fluid and an output flow of a mist of the cleaning fluid at substantially one atmosphere ambient pressure, and an activator positioned to activate the mist of the cleaning fluid to produce the activated cleaning fluid mist wherein atoms of the cleaning fluid are activated. The activated cleaning fluid mist is contacted to a location to be decontaminated.
    Type: Application
    Filed: November 1, 2001
    Publication date: February 20, 2003
    Inventors: Ralph M. Sias, Heath E. Sias, Stanley J. Diniz, Fernando Guerrero, J. Michael Pierce, Louis Montulli
  • Publication number: 20020142452
    Abstract: A method and composition for deinking noncontact-printed wastepaper, particularly xerographic and laser-printed paper, and mixtures of contact and noncontact-printed wastepaper, using an enzyme mixture characterized by a high ratio of &bgr;-glucosidase activity to filter paper units (FPU) activity. The present invention also relates to an assay for evaluating enzymes for use in deinking wastepaper based on the ratio of &bgr;-glucosidase activity to FPU activity.
    Type: Application
    Filed: October 22, 2001
    Publication date: October 3, 2002
    Inventors: Jan L. Yang, Jianhua Ma, J. Michael Pierce, Karl-Erik L. Eriksson
  • Patent number: 6426200
    Abstract: A method and composition for deinking noncontact-printed wastepaper, particularly xerographic and laser-printed paper, and mixtures of contact and noncontact-printed wastepaper, using an enzyme mixture characterized by a high ratio of &bgr;-glucosidase activity to filter paper units (FPU) activity. The present invention also relates to an assay for evaluating enzymes for use in deinking wastepaper based on the ratio of &bgr;-glucosidase activity to FPU activity.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: July 30, 2002
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Jan L. Yang, Jianhua Ma, J. Michael Pierce, Karl-Erik L Eriksson
  • Patent number: 6146849
    Abstract: The present disclosure provides a novel family of C-type lectins from vertebrates. As specifically exemplified, this family of lectins includes a melibiose-specific lectin (XL35) from Xenopus laevis oocytes, and two human lectins, HL-3 and HL-13, specifically expressed in endothelial cells such as blood vessels, stomach, small intestine, heart and tissue and in small intestine, respectively. Amino acid sequences of the lectin proteins are provided herein, together with the nucleotide sequences encoding these proteins.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: November 14, 2000
    Assignee: University of Georgia Research Foundation Inc.
    Inventors: J. Michael Pierce, Kelley W. Moremen, Jin Kyu Lee
  • Patent number: 5602003
    Abstract: The present invention provides a substantially purified UDP-N-acetylglucosamine:.alpha.-6-D-mannoside .beta.-1,6-N-acetylglucosaminyltransferase (GlcNAc T-V; EC 2.4.1.155) and antibodies which specifically bind GlcNAc T-V. The present invention also provides polynucleotide sequences and oligonucleotide probes capable of specifically hybridizing to nucleic acid sequences which encode GlcNAc T-V, and cDNA and genomic clones encoding GlcNAc T-V, as well as nucleotide sequences encoding GlcNAc T-V, as specifically exemplified by a GlcNAc T-V coding sequence from rat.
    Type: Grant
    Filed: February 10, 1993
    Date of Patent: February 11, 1997
    Assignee: University of Georgia Research Foundation
    Inventors: J. Michael Pierce, Mohamed G. Shoreibah, Beverly S. Adler, Nevis L. Fregien