Patents by Inventor J. Milton Harris

J. Milton Harris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190134208
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Application
    Filed: December 28, 2018
    Publication date: May 9, 2019
    Inventors: J Milton Harris, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas
  • Publication number: 20190070301
    Abstract: The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
    Type: Application
    Filed: September 27, 2018
    Publication date: March 7, 2019
    Inventors: J. Milton HARRIS, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas, Francesco Maria Veronese, Anna Mero
  • Publication number: 20190055354
    Abstract: The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.
    Type: Application
    Filed: October 19, 2018
    Publication date: February 21, 2019
    Inventors: Samuel P. McManus, Antoni Kozlowski, J. Milton Harris
  • Publication number: 20190022236
    Abstract: Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
    Type: Application
    Filed: January 31, 2018
    Publication date: January 24, 2019
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Patent number: 10166294
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: January 1, 2019
    Assignee: Serina Therapeutics, Inc.
    Inventors: J Milton Harris, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas
  • Patent number: 10144804
    Abstract: The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: December 4, 2018
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski, J. Milton Harris
  • Publication number: 20180282476
    Abstract: Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(C?O)OR?, wherein R? is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.
    Type: Application
    Filed: June 5, 2018
    Publication date: October 4, 2018
    Inventors: J. Milton Harris, Antoni Kozlowski, Lihong Guo
  • Patent number: 10086084
    Abstract: The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: October 2, 2018
    Assignee: Serina Therapeutics, Inc.
    Inventors: J Milton Harris, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Francesco Maria Veronese, Tacey Viegas
  • Publication number: 20180256599
    Abstract: The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water-soluble oligomer.
    Type: Application
    Filed: October 19, 2017
    Publication date: September 13, 2018
    Inventors: Wen Zhang, Jennifer Riggs-Sauthier, J. Milton Harris, Michael D. Bentley
  • Patent number: 10035880
    Abstract: Provided are methods of preparing heterobifunctional poly(ethylene glycol) derivatives (e.g., HO-PEG-OCH2CO2H) by alkylating poly(ethylene glycol). A method comprises: (a) synthesizing Ar—CR1R2O-Poly-OH (e.g., Bz-PEG-OH, where Bz is benzyl) by forming a polymer Poly (e.g., HO-PEG-OH) onto the aryl methyl oxide ion, Ar—CR1R2O?; (b) alkylating Ar—CR1R2O-Poly-OH to form Ar—CR1R2—O-poly-OR9 (e.g., Bz-O-PEG-OCH2CO2(CH3)3); (c) converting the Ar—CR1R2O— moiety to —OH by acid-catalyzed hydrolysis or hydrogenolysis to form a new mixture of R9O-PEG-OH and R9O-PEG-OR9 (e.g., HO-PEG-OCH2CO2H and HO2CCH2O-PEG-OCH2CO2H); and (d) optionally, isolating the R9O-PEG-OH product formed in (c). The method of the present invention obviates the extensive and laborious purification prior art steps normally required to remove HO-Poly-OH (e.g., HO-PEG-OH) from a preparation of the PEG derivatives.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: July 31, 2018
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, J. Milton Harris, Antoni Kozlowski
  • Patent number: 10011682
    Abstract: Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(C?O)OR?, wherein R? is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: July 3, 2018
    Assignee: NEKTAR THERAPEUTICS
    Inventors: J. Milton Harris, Antoni Kozlowski, Lihong Guo
  • Patent number: 9913913
    Abstract: A method for preparing a polymeric reagent is provided, which method includes the optional step of forming an N-hydroxysuccinimdyl ester derivative. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 13, 2018
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Publication number: 20170173171
    Abstract: The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
    Type: Application
    Filed: March 8, 2017
    Publication date: June 22, 2017
    Inventors: J. Milton Harris, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Francesco Maria Veronese, Tacey Viegas
  • Publication number: 20170073468
    Abstract: The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.
    Type: Application
    Filed: November 22, 2016
    Publication date: March 16, 2017
    Inventors: Samuel P. McManus, Antoni Kozlowski, J. Milton Harris
  • Publication number: 20160324974
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Application
    Filed: June 16, 2016
    Publication date: November 10, 2016
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Publication number: 20160317673
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Application
    Filed: July 8, 2016
    Publication date: November 3, 2016
    Inventors: J Milton HARRIS, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas
  • Patent number: 9399070
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: July 26, 2016
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Patent number: 9284411
    Abstract: The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other polyoxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: March 15, 2016
    Assignee: Serina Therapeutics, Inc.
    Inventors: Michael D Bentley, J Milton Harris, Kunsang Yoon, Michael Reif, Rainer Jordan
  • Publication number: 20150328331
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Application
    Filed: May 22, 2015
    Publication date: November 19, 2015
    Applicant: NEKTAR THERAPEUTICS
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Patent number: 9169354
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: October 27, 2015
    Assignee: Serina Therapeutics, Inc.
    Inventors: Kunsang Yoon, J. Milton Harris, Michael David Bentley