Abstract: A method, system, and computer program product for bit flip aware latch placement in integrated circuit generation are provided. The method identifies a chip design for an integrated circuit. A set of chip design constraints, associated with the chip design, is identified. A set of checking groups, associated with a plurality of latches to be placed in the chip design, is determined. Based on the set of chip design constraints and the set of checking groups, a placement scheme for the plurality of latches is selected. The method places the plurality of latches within the chip design based on the placement scheme and the set of checking groups.

Abstract: A renal therapy system is disclosed. In an example, the renal therapy system includes a home renal therapy machine that stores, to a log file, dates of when renal therapies were performed and a type of each renal therapy that was performed. The system also includes a server that receives the log file from the home renal therapy machine. The server compares the dates and types of performed renal therapies stored in the log file to a device program that specifies dates for performing renal therapies and the types of renal therapies to be performed. The server displays a flag in a user interface of a clinician computer when there is a deviation from the comparison.

Abstract: Compositions and methods for treating a retinopathy or inhibiting pathologic neovascularization in a subject are provided herein. In one embodiment, the method includes ablating or inhibiting IDO-dependent vascularizing cells (IDVCs) in the eye of the subject. Various methods of inhibiting or ablating IDVCs are described, including inhibiting IDO1 and/or integrated response nodes.

Abstract: A force dissipating device in a footwear appliance includes an actuator responsive to a displacement force from a shoe sole surface, and an elastic field of resilient, compressible material. The elastic field is elongated in a direction aligned with the displacement force, and an inclined surface is attached to the actuator and disposed against the elastic field. The actuator is adapted for movement parallel to the elastic field, while the inclined surface is oriented to compress the elastic field in a direction defined by the inclined surface. The inclined surface is oriented at an angle to compress the elastic field in a direction substantially perpendicular to vertical actuator displacement, thus providing a constant region of opposed, compressive force that is generally constant, rather than increasing with displacement distance.

Abstract: The present invention relates to a magnetic field exposure system for use in exposing organic cells, cellular tissue or at least a part of a subject to a low frequency magnetic field. The system includes a magnetic field generator and amplifier feeding one or more electromagnetic coils configured to produce a magnetic field that varies according to an amplitude modulated signal with a carrier frequency of from 360 to 450. Hz, wherein the modulation frequency is from 0.5 to 100. Hz; and wherein the MF has a field strength of from 0.5 to 250 ?T.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.

Abstract: A software development system and method which reduces development cycle times, improves software quality, and indicates speed to market for software is provided. The system integrates development resources to streamline the process of utilizing those resources by a developer or other personnel. A software development workbench and associated toolchain may be used to further improve the software development process.

Abstract: A force absorbing device for a footwear appliance includes a shoe upper and a shoe sole having a planar sole surface, such that forces between the shoe upper and planar sole surface in ground contact are absorbed by force mitigation assemblies disposed in the shoe sole. A force mitigation assembly adapted for an athletic shoe includes a linkage to a wearer interface responsive to movement based on activity of the wearer. An attachment to a sole surface receives ground forces transmitted from frictional contact between the sole surface and a surface against which the sole is disposed, such as for running, turning, etc. A force mitigation assembly absorbs these forces received from the sole surface for directing the received force in a controlled manner. An elastic field in the force mitigation assembly is defined by a resilient material adapted to deform in response to the received force.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.

Abstract: A force absorbing device for a footwear appliance includes a shoe upper and a shoe sole having a planar sole surface, such that forces between the shoe upper and planar sole surface in ground contact are absorbed by force mitigation structures disposed in the shoe sole. A footwear article includes a split-sole system that redefines a shoe sole as coplanar surfaces having a force mitigating interface for receiving sudden forces and effectively mitigating these forces by storing kinetic energy and releasing it over time. An elastic field in the force mitigation structure is defined by a resilient material adapted to deform in response to the received force. Frictional engagement between the upper and lower sole may also be augmented by surface characteristics such as dimples, voids and lubricants, in addition to interference engagement with an elastic field.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.

Abstract: In one example, a network entity obtains a network packet including data. The network entity performs a deterministic mathematical computation on the data to produce a string of characters derived from the data and inserts an indication of the string of characters into the network packet. The network entity provides the indication of the string of characters to a distributed ledger based on a secret unique identifier of the network entity. The distributed ledger stores the indication of the string of characters and records an indication of a time at which the indication of the string of characters was stored in the distributed ledger. The network entity obtains, from the distributed ledger, the indication of the time and inserts the indication of the time into the network packet. The network entity provides the network packet towards a destination.

Abstract: Systems and methods for distributed ledger-based software supply chain management are disclosed. According to one embodiment, in an information processing apparatus comprising at least one computer processor, a method for distributed ledger-based software supply chain management may include: (1) receiving, from a software tool, a metadata artifact for a software development lifecycle event; (2) writing the metadata artifact to a metadata store; and (3) updating a present state database with values for metadata keys referencing the metadata artifact in the metadata store.

Abstract: A protective headgear device, or helmet, protects against head injuries such as concussions and CTE by imposing a network of constant force members (CFMs) between an outer impact shell and an inner fitted capsule engaging the skull/head surface. CFMs exhibit a force absorbing behavior that differs from conventional linear spring behavior that impose a counterforce proportional to the displaced distance. CFMs occupy a compact void between the outer impact shell and the inner fitted capsule by component miniaturization and tethers that redirect forces within the void. An absence of conventional foam and straps increases accommodation for the CFMs and connection tethers/attachments. The CFMs exhibit a substantially constant force that avoids a sharp impactful response associated with head injuries.

Abstract: A software development system and method which reduces development cycle times, improves software quality, and indicates speed to market for software is provided. The system integrates development resources to streamline the process of utilizing those resources by a developer or other personnel. A software development workbench and associated toolchain may be used to further improve the software development process.

Abstract: A system and method for managing a software development project is provided. The system integrates software development workbench and associated toolchain to link a plurality of software development tools according to a dependency that illustrates a relationship between the plurality of software development tools to indicate to a developer that the one or more software development tools necessary to build, test, deploy, and/or run the software development project, and to indicate the operational status of the a plurality of software development tools to streamline the process of utilizing those tools by a developer or other personnel.

Abstract: An impact absorbing footwear device employs opposed planar sole portions engaged by a selective resistance coupling that biases the opposed planar sole portions in a non-linear manner in response to forces exerted by the wearer against the sole portion in frictional contact with a floor surface. The planar sole portions are disposed in a footwear appliance that takes the form of an athletic shoe sole. The selective resistance coupling includes a plurality of resilient deformation members that engage the planar sole portions in an opposed circumferentially aligned manner, selectively deform in response to pressure exerted by the wearer for preventing ACL and other impact related injuries, and recover to an undeformed rest position without breakaway to allow the wearer uninterrupted usage while dampening forces that surpass an injury threshold from the resilient deformation that allows the planar sole portions to temporarily misalign.

Abstract: Compositions and methods for the treatment of cancer are disclosed.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.