Patents by Inventor J. Oakey Noell
J. Oakey Noell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7125481Abstract: An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.Type: GrantFiled: June 9, 2004Date of Patent: October 24, 2006Assignee: Bayer HealthCare LLCInventors: Matthew K. Musho, J. Oakey Noell, Andrew J. Edelbrock, Dijia Huang
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Patent number: 6841052Abstract: An improved electrochemical sensor having a base bearing a working and counter electrode which provides a flow path for a fluid test sample. The working and counter electrodes are configured so that a major portion of the counter electrode is located downstream on the flow path from the working electrode with the exception of a small sub-element of the counter electrode which is in electrical communication with the primary portion of the counter electrode and located upstream of the working electrode. This configuration enables the sensor when the capillary space is incompletely filled with test fluid.Type: GrantFiled: May 21, 2001Date of Patent: January 11, 2005Assignee: Bayer CorporationInventors: Matthew K. Musho, J. Oakey Noell, Andrew J. Edelbrock, Dijia Huang
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Publication number: 20040222092Abstract: Disclosed is an improved electrochemical sensor having a base bearing a working and counter electrode which provides a flow path for a fluid test sample. The working electrode has a reaction layer on its surface which contains an enzyme capable of reacting with an analyte to produce electrons which are received by the working electrode. The base is mated with a cover to form a capillary space into which the test fluid is drawn. The improvement involves configuring the working and counter electrodes so that a major portion of the counter electrode is located downstream on the flow path from the working electrode with the exception of a small sub-element of the counter electrode which is in electrical communication with the primary portion of the counter electrode and located upstream of the working electrode.Type: ApplicationFiled: June 9, 2004Publication date: November 11, 2004Inventors: Matthew K. Musho, J. Oakey Noell, Andrew J. Edelbrock, Dijia Huang
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Publication number: 20040200720Abstract: Disclosed is an improved electrochemical sensor having a base bearing a working and counter electrode which provides a flow path for a fluid test sample. The working electrode has a reaction layer on its surface which contains an enzyme capable of reacting with an analyte to produce electrons which are received by the working electrode. The base is mated with a cover to form a capillary space into which the test fluid is drawn. The improvement involves configuring the working and counter electrodes so that a major portion of the counter electrode is located downstream on the flow path from the working electrode with the exception of a small sub-element of the counter electrode which is in electrical communication with the primary portion of the counter electrode and located upstream of the working electrode.Type: ApplicationFiled: May 21, 2001Publication date: October 14, 2004Applicant: Bayer CorporationInventors: Matthew K. Musho, J. Oakey Noell, Andrew J. Edelbrock, Dijia Huang
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Patent number: 6673630Abstract: One embodiment of the present invention improves the visual use of urine test strips and reagent pads by providing a single color from a reference color spectrum directly on the colorimetric strip and adjacent to the reagent area to allow easy comparison. After application of a fluid to be tested to a reagent area on the colorimetric strip, a technician is able to easily compare the color in the reagent area to the reference color area(s) to determine the presence or absence of, for example, glucose, in the fluid. Placing at least one reference color immediately next to the reagent area markedly improves technician's accuracy in comparing and analyzing the reagent area against the reference color(s). The present invention allows a technician to easily and quickly compare a reagent area color to more than one reference area to determine the actual numerical value of, for example, the pH in the tested fluid.Type: GrantFiled: February 23, 2000Date of Patent: January 6, 2004Assignee: Bayer CorporationInventors: James P. Albarella, J. Oakey Noell, Michael J. Pugia
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Patent number: 6531040Abstract: Disclosed is an electrochemical sensor for detecting the concentration of an analyte such as glucose in a fluid test sample. The sensor involves a base as flow path for the fluid test sample having a working and counter electrode on its surface. The base is mated with a cover to form a capillary space to capture the fluid and the counter electrode has a sub-element located upstream in the flow path. When there is detected electrical communication only between the sub-element and the working electrode the meter, with which the sensor is in electrical communication senses that the capillary space has not completely filled with test fluid.Type: GrantFiled: December 8, 2000Date of Patent: March 11, 2003Assignee: Bayer CorporationInventors: Matthew K. Musho, J. Oakey Noell, Andrew J. Edelbrock
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Publication number: 20020031840Abstract: One embodiment of the present invention improves the visual use of urine test strips and reagent pads by providing a single color from a reference color spectrum directly on the colorimetric strip and adjacent to the reagent area to allow easy comparison. After application of a fluid to be tested to a reagent area on the colorimetric strip, a technician is able to easily compare the color in the reagent area to the reference color area(s) to determine the presence or absence of, for example, glucose, in the fluid. Placing at least one reference color immediately next to the reagent area markedly improves technician's accuracy in comparing and analyzing the reagent area against the reference color(s). The present invention allows a technician to easily and quickly compare a reagent area color to more than one reference area to determine the actual numerical value of, for example, the pH in the tested fluid.Type: ApplicationFiled: February 23, 2000Publication date: March 14, 2002Inventors: James P Albarella, J Oakey Noell, Michael J Pugia
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Publication number: 20010042683Abstract: Disclosed is an improved electrochemical sensor having a base bearing a working and counter electrode which provides a flow path for a fluid test sample. The working electrode has a reaction layer on its surface which contains an enzyme capable of reacting with an analyte to produce electrons which are received by the working electrode. The base is mated with a cover to form a capillary space into which the test fluid is drawn. The improvement involves configuring the working and counter electrodes so that a major portion of the counter electrode is located downstream on the flow path from the working electrode with the exception of a small sub-element of the counter electrode which is in electrical communication with the primary portion of the counter electrode and located upstream of the working electrode.Type: ApplicationFiled: December 8, 2000Publication date: November 22, 2001Applicant: Bayer CorporationInventors: Matthew K. Musho, J. Oakey Noell, Andrew J. Edelbrock
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Patent number: 5250439Abstract: A conductive sensor and its use in a diagnostic assay are disclosed. The miniaturized conductive sensor, utilizing a conducting polymer, is used in a diagnostic device to determine the presence or concentration of a predetermined analyte in a liquid test sample, wherein the predetermined analyte, like glucose, is assayed by an oxidase interaction. The interaction between the oxidase and a small amount of the predetermined analyte in the test sample generates, either directly or indirectly, a dopant compound in a reaction zone of the conductive sensor. The dopant compound then migrates to the detection zone of the conductive sensor of the diagnostic device to oxidize the conducting polymer and convert the conducting polymer from an insulating form to a conducting form. The resulting increase in conductivity of the conducting polymer is measured, then the conductivity increase is correlated to the concentration of the predetermined analyte in the test sample.Type: GrantFiled: December 14, 1992Date of Patent: October 5, 1993Assignee: Miles Inc.Inventors: Matthew K. Musho, J. Oakey Noell, Pius H-S. Tse
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Patent number: 5210217Abstract: Electrically conducting homo- and/or copolymers and/or tripolymers can be produced from novel monomers, such as a 3-substituted 2,5-di(2-thienyl)pyrrole. The polymers exhibit unexpectedly high stability and conductivities, and can be functionalized, such as with an enzyme, like glucose oxidase, or an ion-specific binding site, like a crown ether, or an antigen, without adversely affecting the conductivity of the polymer. The functionalized, conducting polymer can be used in a diagnostic device to determine the presence and concentration of a specific analyte in a liquid medium.Type: GrantFiled: April 10, 1989Date of Patent: May 11, 1993Assignee: Miles Inc.Inventors: James P. Albarella, J. Oakey Noell, Paul O. Vogelhut, Frederick E. Ward, deceased
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Patent number: 5202261Abstract: A conductive sensor and its use in a diagnostic assay are disclosed. The miniaturized conductive sensor, utilizing a conducting polymer, is used in a diagnostic device to determine the presence or concentration of a predetermined analyte in a liquid test sample, wherein the predetermined analyte, like glucose, is assayed by an oxidase interaction. The interaction between the oxidase and a small amount of the predetermined analyte in the test sample generates, either directly or indirectly, a dopant compound in a reaction zone of the conductive sensor. The dopant compound then migrates to the detection zone of the conductive sensor of the diagnostic device to oxidize the conducting polymer and convert the conducting polymer from an insulating form to a conducting form. The resulting increase in conductivity of the conducting polymer is measured, then the conductivity increase is correlated to the concentration of the predetermined analyte in the test sample.Type: GrantFiled: November 18, 1991Date of Patent: April 13, 1993Assignee: Miles Inc.Inventors: Matthew K. Musho, J. Oakey Noell, Pius H. Tse
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Patent number: 5119819Abstract: A new and improved method and apparatus are provided for non-invasive monitoring of changes in blood glucose concentration in a tissue specimen and particularly in an individual. The method uses acoustic velocity measurements for monitoring the effect of glucose concentration upon the density and adiabatic compressibility of the serum.In a preferred embodiment, the acoustic velocity measurements are made through the earlobe of a subject by means of an acoustic probe or monitor which includes a transducer for transmitting and receiving ultrasonic energy pulses to and from the blood flowing in the subject's earlobe and a reflector for facilitating reflection of the acoustic pulses from the blood. The probe is designed in such a way that when properly affixed to an ear, the transducer is positioned flush against the anterior portion of an earlobe while the reflector is positioned flush against the interior portion of the earlobe.Type: GrantFiled: May 2, 1990Date of Patent: June 9, 1992Assignee: Miles Inc.Inventors: Graham H. Thomas, Roger M. Watson, J. Oakey Noell
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Patent number: 4886625Abstract: Electrically conducting homo- and/or copolymers and/or tripolymers can be produced from novel monomers, such as a 3-substituted 2,5-di(2-thienyl)pyrrole. The polymers exhibit unexpectedly high stability and conductivities, and can be functionalized, such as with an enzyme, like glucose oxidase, or an ion-specific binding site, like a crown ether, or an antigen, without adversely affecting the conductivity of the polymer. The functionalized, conducting polymer can be used in a diagnostic device to determine the presence and concentration of a specific analyte in a liquid medium.Type: GrantFiled: October 29, 1987Date of Patent: December 12, 1989Assignee: Miles Inc.Inventors: James P. Albarella, J. Oakey Noell, Paul O. Vogelhut, deceased, Frederick E. Ward
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Patent number: RE44521Abstract: An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.Type: GrantFiled: October 23, 2008Date of Patent: October 8, 2013Assignee: Bayer HealthCare LLCInventors: Matthew K. Musho, J. Oakey Noell, Andrew J. Edelbrock, Dijia Huang
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Patent number: RE45384Abstract: An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.Type: GrantFiled: September 9, 2013Date of Patent: February 24, 2015Assignee: Bayer HealthCare LLCInventors: Matthew K. Musho, J. Oakey Noell, Andrew J. Edelbrock, Dijia Huang