Patents by Inventor J. Paul Brooks

J. Paul Brooks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cost-optimized design analysis for rapid microbial prototyping
    Patent number: 10102335
    Abstract: Computer-implemented methods for providing improvements in genome-scale metabolic models are described. The methods identify and optimize metabolic flux states that minimize the cost of enzyme production while maximizing a desired cellular phenotype. The computer-implemented methods may maximize cellular phenotypes such as growth (biomass) or production of a metabolite, such as a commercially valuable chemical compound, through the selection of metabolic pathways that maximize these phenotypes while minimizing metabolic costs associated with production of the proteomic constituents of individual metabolic pathways. The computer implemented methods may be useful for computationally designing microbial strains for the production of chemicals.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: October 16, 2018
    Assignee: Virginia Commonwealth University
    Inventors: Adam Fisher, J. Paul Brooks, Stephen S. Fong
  • COST-OPTIMIZED DESIGN ANALYSIS FOR RAPID MICROBIAL PROTOTYPING
    Publication number: 20140172318
    Abstract: Computer-implemented methods for providing improvements in genome-scale metabolic models are described. The methods identify and optimize metabolic flux states that minimize the cost of enzyme production while maximizing a desired cellular phenotype. The computer-implemented methods may maximize cellular phenotypes such as growth (biomass) or production of a metabolite, such as a commercially valuable chemical compound, through the selection of metabolic pathways that maximize these phenotypes while minimizing metabolic costs associated with production of the proteomic constituents of individual metabolic pathways. The computer implemented methods may be useful for computationally designing microbial strains for the production of chemicals.
    Type: Application
    Filed: December 19, 2013
    Publication date: June 19, 2014
    Inventors: Adam Fisher, J. Paul Brooks, Stephen S. Fong