Patents by Inventor J. Paul TAYLOR

J. Paul TAYLOR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR IDENTIFYING MODULATORS OF G3BP ACTIVITY
    Publication number: 20220091120
    Abstract: A method of identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) is provided, which includes determining whether a compound modulates the interaction between the N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and FGDF peptide of ubiquitin specific protease 10 (USP10) or non-structural protein 3 (nsP3).
    Type: Application
    Filed: December 3, 2021
    Publication date: March 24, 2022
    Inventors: J. Paul TAYLOR, Peiguo YANG, Wenwei LIN, Taosheng CHEN
  • Method for identifying modulators of G3BP activity
    Patent number: 11237168
    Abstract: A method of identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) is provided, which includes determining whether a compound modulates the interaction between the N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and FGDF peptide of ubiquitin specific protease 10 (USP10) or non-structural protein 3 (nsP3).
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: February 1, 2022
    Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
    Inventors: J. Paul Taylor, Peiguo Yang, Wenwei Lin, Taosheng Chen
  • FUSION PROTEIN AND NUCLEIC ACID MOLECULE FOR EXOGENOUS STIMULANT-DEPENDENT STRESS GRANULE ASSEMBLY
    Publication number: 20210179676
    Abstract: A nucleic acid molecule encoding a fusion protein composed of an inducible multimerization moiety at the amino terminus, and a GTPase-Activating Protein SH3 Domain-Binding Protein (G3BP) is provided for exogenous stimulus/G3BP-mediated stress granule formation. Further disclosed are chemical or light inducible multimerization proteins or protein domains that can be used for the nucleic acid molecule production, and a method of inducing stress granule formation in a cell comprising expressing the nucleic acid molecule.
    Type: Application
    Filed: October 26, 2018
    Publication date: June 17, 2021
    Inventors: J. Paul Taylor, Peipei Zhang
  • METHOD FOR IDENTIFYING MODULATORS OF G3BP ACTIVITY
    Publication number: 20200408759
    Abstract: A method of identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) is provided, which includes determining whether a compound modulates the interaction between the N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and FGDF peptide of ubiquitin specific protease 10 (USP10) or non-structural protein 3 (nsP3).
    Type: Application
    Filed: June 26, 2019
    Publication date: December 31, 2020
    Applicant: St. Jude Children's Research Hospital
    Inventors: J. Paul TAYLOR, Peiguo YANG, Wenwei LIN, Taosheng CHEN