Abstract: An improved retention system for retaining fuel rods in a fuel assembly is disclosed. The retention system includes a plurality of first engagement surfaces on the bottom nozzle of a fuel assembly. There is at least one engagement surface for each fuel rod. A second engagement surface is formed on the bottom end plug of each fuel rod. The first and second engagement surfaces are configured for engagement with each other for axially and laterally retaining each fuel rod within the fuel assembly. Debris deflectors may also be provided to deflect debris from coolant channels surrounding the fuel rods.

Abstract: This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.

Abstract: The invention relates to the treatment of thromboembolic conditions, to fibrin clot formation and related thrombin activity, and to preparation of compounds, in particular, peptides and polypeptides for inhibiting, or for modifying the cleavage of fibrinogen by thrombin.

Abstract: A portable illumination apparatus such as, for example, a task light, that is lightweight and compact to provide enhanced illumination in an ambient environment when placed in one of a plurality of operating modes. The portable illumination apparatus includes a support base and a light module that includes one or more light sources and a rechargeable power source. The light module may be manually manipulated for movement between a collapsed, stowed position and a deployed position by rotation of about a first rotational axis. In the deployed position, the light module is rotatable about the second rotational axis that is perpendicular to the first rotational axis. The support base incorporates a carabiner clip member that facilitates secure attachment of the portable illumination apparatus to an object or surface in a manner that facilitates hands-free use of the portable illumination apparatus.

Abstract: A portable flashlight apparatus is provided that is lightweight and compact to provide enhanced illumination in an ambient environment when placed in one of a plurality of operating modes. The portable flashlight apparatus includes a base housing defining an interior space and which includes structurally defined regions that include a front housing region, a rear housing region, an intermediate housing region extending between the front housing region and the rear housing region and an end cap that closes the interior space at the rear housing region. A light module includes a first light source operable to emit illuminating light, a second light source operable to emit laser light, and a third light source operable to emit illuminating light. A magnet are arranged at the rear face of the end cap, and is operable to magnetically bias the base housing on a working surface or support surface having magnetic properties.

Abstract: An improved retention and alignment system for nuclear fuel rods includes an upper nozzle plate and a lower nozzle plate, nuclear fuel rods, each having an upper end and a lower end and extending axially between the upper and lower nozzle plates, a first precision magnet incorporated onto the lower end of the fuel rod, and a plurality of second precision magnets incorporated onto the lower nozzle plate in positions confronting the first precision magnets on the fuel rods. Each first precision magnet has at least one of a magnetic north or south polarity and the second precision magnet has at least one of a magnetic south or north polarity opposite the polarity of the confronting first precision magnet to effect magnetic attraction between the confronting first and second precision magnets. Grids between the upper and lower nozzle plates form cells through which the fuel rods pass.

Abstract: Disclosed herein are EPDM-VNB copolymers that have a low molecular weight and are liquid at room temperature. The copolymers include: ethylene, propylene, and vinyl norbornene, where the copolymers have a molecular weight from about 2,500 g/mol to about 1,000,000 g/mol, and where the copolymers have a viscosity from about 1,000 cP to about 2,500,000 cP at 100° C.

Abstract: The disclosure relates to the synthesis of amide containing compounds inflow. In particular, the disclosure relates to the synthesis of polypeptides via native chemical ligation inflow. The disclosure also relates to selective desulfurization or deselenization of amide containing compounds comprising a thiol, disulfide, selenol or diselenide functional group respectively, particularly polypeptides.

Abstract: An improved retention and alignment system for nuclear fuel rods includes an upper nozzle plate and a lower nozzle plate, nuclear fuel rods, each having an upper end and a lower end and extending axially between the upper and lower nozzle plates, a first precision magnet incorporated onto the lower end of the fuel rod, and a plurality of second precision magnets incorporated onto the lower nozzle plate in positions confronting the first precision magnets on the fuel rods. Each first precision magnet has at least one of a magnetic north or south polarity and the second precision magnet has at least one of a magnetic south or north polarity opposite the polarity of the confronting first precision magnet to effect magnetic attraction between the confronting first and second precision magnets. Grids between the upper and lower nozzle plates form cells through which the fuel rods pass.

Abstract: An improved retention system for retaining fuel rods in a fuel assembly is disclosed. The retention system includes a plurality of first engagement surfaces on the bottom nozzle of a fuel assembly. There is at least one engagement surface for each fuel rod. A second engagement surface is formed on the bottom end plug of each fuel rod. The first and second engagement surfaces are configured for engagement with each other for axially and laterally retaining each fuel rod within the fuel assembly. Debris deflectors may also be provided to deflect debris from coolant channels surrounding the fuel rods.

Abstract: The invention relates to anti-inflammatory peptides, to pharmaceutical compositions comprising same and to uses thereof for treatment of inflammation including, but not limited to inflammation associated with immune activation.

Abstract: An improved retention and alignment system for nuclear fuel rods includes an upper nozzle plate and a lower nozzle plate, nuclear fuel rods, each having an upper end and a lower end and extending axially between the upper and lower nozzle plates, a first precision magnet incorporated onto the lower end of the fuel rod, and a plurality of second precision magnets incorporated onto the lower nozzle plate in positions confronting the first precision magnets on the fuel rods. Each first precision magnet has at least one of a magnetic north or south polarity and the second precision magnet has at least one of a magnetic south or north polarity opposite the polarity of the confronting first precision magnet to effect magnetic attraction between the confronting first and second precision magnets. Grids between the upper and lower nozzle plates form cells through which the fuel rods pass.

Abstract: A nuclear fuel assembly having lateral support provided by a bimetallic spring that extends from a side of the fuel assembly under certain core conditions to pressure against an adjacent component and withdraws under other core conditions, such as shutdown, to enable the nuclear fuel assembly to be aligned or withdrawn from the core and repositioned.

Abstract: A system includes a scleral prosthesis and an insert. The scleral prosthesis includes a first end configured to be pulled through a scleral tunnel in an eye and a second end. Each end is wider than a middle portion of the scleral prosthesis. Two portions form the first end of the scleral prosthesis, and the portions are separated along at least half of a length of the scleral prosthesis. The scleral prosthesis is formed from a single integrated piece of material. The second end is undivided. The insert is configured to be placeable between the two portions. The two portions may be separated from one another without external interference, and the two portions may be configured to be pushed towards each other in order to reduce a width of the first end and then separate after release.

Abstract: This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.