Abstract: The disclosure provides compositions, methods, and kits that facilitate the characterization of omic variation in tissues while preserving spatial information related to the origin of target analytes in the tissue.

Abstract: A control device may include a processor may include a core, a timer peripheral, and a peripheral direct memory access controller. The processor may include a receive port coupled to a communication port of the reporting device via a communication line. The control device may include a timer peripheral that can generate an enable signal and a timing signal, and a buffer circuit that may include an enable port for the enable signal for enabling/disabling the buffer circuit, an input port for the timing signal, and an output port coupled to the communication line. The processor may enable/disable the buffer circuit to control the timing of data bit(s) transmission across the communication line by the reporting device. The peripheral direct memory access controller may store the data bit(s) in a receive buffer during the bit period, and the core may subsequently retrieve the data bit(s) from the receiver buffer.

Abstract: A generator comprising an interface and a control circuit is disclosed. The interface is to electrically couple to an ultrasonic surgical instrument comprising a switch. The switch is configurable between a first switch state and a second switch state. The control circuit is to provide a continuous drive signal to the ultrasonic surgical instrument based on the switch being in the first switch state. The control circuit is to provide a pulsed drive signal to the ultrasonic surgical instrument based on the switch being in the second switch state.

Abstract: A control device may include a processor may include a core, a timer peripheral, and a peripheral direct memory access controller. The processor may include a receive port coupled to a communication port of the reporting device via a communication line. The control device may include a timer peripheral that can generate an enable signal and a timing signal, and a buffer circuit that may include an enable port for the enable signal for enabling/disabling the buffer circuit, an input port for the timing signal, and an output port coupled to the communication line. The processor may enable/disable the buffer circuit to control the timing of data bit(s) transmission across the communication line by the reporting device. The peripheral direct memory access controller may store the data bit(s) in a receive buffer during the bit period, and the core may subsequently retrieve the data bit(s) from the receiver buffer.

Abstract: Disclosed are a process and autoclave reactor configured to create, in a polymerization zone of the autoclave reactor, a first mixing current, a second mixing current, and an interface located between the first mixing current and the second mixing current, wherein the interface is offset from a reaction component inlet of the autoclave reactor that introduces a reaction component stream into the polymerization zone.

Abstract: Various embodiments are directed to a method of driving an end effector coupled to an ultrasonic drive system of a surgical instrument. The method comprises generating at least one electrical signal. The at least one electrical signal is monitored against a first set of logic conditions. A first response is triggered when the first set of logic conditions is met. A parameter is determined from the at least one electrical signal.

Abstract: A method for determining motional branch current in an ultrasonic transducer of an ultrasonic surgical device over multiple frequencies of a transducer drive signal. The method may comprise, at each of a plurality of frequencies of the transducer drive signal, oversampling a current and voltage of the transducer drive signal, receiving, by a processor, the current and voltage samples, and determining, by the processor, the motional branch current based on the current and voltage samples, a static capacitance of the ultrasonic transducer and the frequency of the transducer drive signal.

Abstract: This invention is in the field of medicinal pharmacology. In particular, the invention relates to a new class of small-molecules having a pyrazino-pyrimidine-dione (or related) structure which function as modulators (activators, inhibitors) of protease activated receptor type 2 (PAR2), and their use as therapeutics for the treatment of conditions involving PAR2 activity (e.g., asthma, chronic pain, cancer and/or vascular disorders).

Abstract: A hydrogen-rich hydrocarbon fuel gas can be separated into a methane fuel stream and a hydrogen product stream. The methane fuel stream can be fed to a methane fuel fired furnace, combustion of the methane fuel stream can produce a carbon-dioxide-rich flue gas, and a carbon capture process can be performed on the carbon-dioxide-rich flue gas. The hydrogen product stream can be fed to a hydrogen fired furnace or elsewhere. Combustion of the hydrogen product stream in a hydrogen fired furnace can generate a flue gas the is low in carbon dioxide. Electrolysis of water obtained from the hydrogen fired furnace flue gas can produce hydrogen for a desired use, such as fuel for the hydrogen fired furnace, and can produce oxygen for enriching the fuel gas fed to the methane fuel fired furnace.

Abstract: Various embodiments are directed to a method of driving an end effector coupled to an ultrasonic drive system of a surgical instrument. The method comprises generating at least one electrical signal. The at least one electrical signal is monitored against a first set of logic conditions. A first response is triggered when the first set of logic conditions is met. A parameter is determined from the at least one electrical signal.

Abstract: An adjustable clip system (1) primarily for use with holsters (3) and holster rigs (2) that attach to a user's belt (17) or waistband (18) or pocket via one or more clips (12). The adjustable clip system allows a user to independently adjust the height of the holster or holster rig without requiring the user to raise or lower the user's belt, waistband, pocket, and/or other clothing to do so.

Abstract: A control circuit is disclosed that comprises a resistor and a switch network. The switch network is configured to transition between a plurality of states corresponding to a plurality of operational modes of a surgical instrument. In a first phase of a control signal, the control circuit is configured to communicate surgical instrument information to a surgical generator. In the second phase of the control signal and when the at least one switch of the switch network is in a first state of the plurality of states, the control circuit is configured to provide an output corresponding to one of the plurality of states. In the second phase of the control signal and when the at least one switch of the switch network is in a second state of the plurality of states, the control circuit is configured to provide a second output.

Abstract: The invention relates to an adjustable clip system primarily for use with sheaths, holsters, and/or holster rigs that attach to a user's belt or waistband or pocket via one or more clips. The adjustable clip system allows a user to independently adjust the height of the sheath, holster, or holster rig without requiring the user to raise, lower, or otherwise adjust the user's belt, waistband, pocket, clothing, and/or other attachment point to adjust the height of the sheath, holster, or holster rig.

Abstract: A “Power Wedge” can be inserted into a pocket of a batting glove, or used separately. The wedge can include an elongate generally teardrop shape, with an interior face that is convexly curved, defining a trough with a curvature that corresponds to the curvature of a bat handle. The wedge can include one or more tethering loops anchored inside the wedge. Such loops may extend from the wedge out the top end of the wedge. A tethering loop can also be provided extending out the bottom tapered end of the wedge, as well. Such loops may be wrapped around the thumb, index finger, and/or wrist of the user. Such tethers can also be wrapped around the bat handle. Such tethers are particularly helpful if the wedge is not received into pocket of a batting glove. The wedge can also be used with golf gloves and golf clubs.

Abstract: Systems and methods for improved mixing, including baffle systems, reactor systems, and methods of using the same are provided herein. These baffle systems include a ring having an exterior surface defining an outer diameter and an outer circumference, an interior surface defining an inner diameter and an inner circumference, a top surface, a bottom surface, and an axis; and one or more substantially vertical baffles extending from the interior surface of the ring toward the axis.

Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a primary dose-limiting side effect caused by antineoplastic agents, such as paclitaxel. This causes damage to peripheral nerves and the dorsal root ganglia (DRG). Currently, there are no effective treatments for CIPN, which can lead to long-term morbidity in patients and survivors. Neuronal-immune interactions occur in CIPN and have been implicated both in the development and progression of the disease and disease resolution. The inventors investigated the potential role of Inducible co-stimulatory molecule (ICOS) in the resolution of CIPN. ICOS is an immune checkpoint molecule that is expressed on the surface of activated T cells and promotes proliferation and differentiation of T cells. They found that intrathecal administration of ICOS agonist antibody (ICOSaa) alleviates mechanical hypersensitivity caused by paclitaxel and facilitates the resolution of pain in female mice without a clear benefit in male mice.

Abstract: A process is provided for bioconversion of carbon monoxide and carbon dioxide. More specifically, the process includes fermenting carbon monoxide and carbon dioxide containing substrate with acetogenic bacteria. The process provides for high levels of carbon monoxide and carbon dioxide conversions and utilization of hydrogen.

Abstract: A CO2, bioconversion process includes providing a CO2 containing substrate to a bioreactor, the CO2 containing substrate including about 5 to about 90 mole % CO2; and fermenting the CO2 containing substrate with an acetogenic bacteria carrying a sodium translocating ATPase. The medium including less than about 0.01 grams per liter yeast extract, less than about 0.01 grams per liter carbohydrate, a sodium ion concentration provided by a sodium ion feed rate of about 290 to about 8750 ?g/gram of cells/minute, and a pH of about 4 to about 6.9.

Abstract: Compounds having activity as inhibitors of MNK are provided. One embodiment provides compounds having Structure (II): Formula (II) or a pharmaceutically acceptable salt, stereoisomer, tautomer, or prodrug thereof, wherein R1a, R1b, R2, X, Y, and L are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of MNK are also provided.