Patents by Inventor Jérôme Albert Joseph Hoet

Jérôme Albert Joseph Hoet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Resolution of (±)-methyl phenyl[4-[4-[[[4?(trifluoromethyl)-2-biphenylyl]carbonyl]amino]Phenyl]-1-piperidinyl]acetate
    Patent number: 8461341
    Abstract: The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: June 11, 2013
    Assignee: Janssen Pharmaceutica NV
    Inventors: Alex Herman Copmans, Jérôme Albert Joseph Hoet, Albert Louis Anna Willemsens, Wouter Louis J Couck, Joannes Petrus Van Dun
  • RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE
    Publication number: 20120071660
    Abstract: The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
    Type: Application
    Filed: May 27, 2010
    Publication date: March 22, 2012
    Inventors: Alex Herman Copmans, Jérôme Albert Joseph Hoet, Albert Louis Anna Willemsems, Wouter Louis J. Couck, Joaanes Petrus Van Dun