Patents by Inventor Jérôme Guicheux
Jérôme Guicheux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230181462Abstract: The present invention provides crosslinking pairs of hydrogel precursor polymers, dynamic covalent hydrogels prepared from such crosslinking pairs of hydrogel precursors, pharmaceutical compositions comprising such precursors or hydrogels and uses thereof in a variety of applications.Type: ApplicationFiled: March 10, 2021Publication date: June 15, 2023Applicants: Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Nantes UniversiteInventors: Vianney Delplace, Jérôme Guicheux, Catherine Le Visage, Arnaud Tessier
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Patent number: 10632203Abstract: The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.Type: GrantFiled: April 10, 2018Date of Patent: April 28, 2020Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITE DE NANTESInventors: Pierre Weiss, Eva Mathieu, Jerome Guicheux, Patricia Lemarchand
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Patent number: 10632154Abstract: The present invention relates to the use of insulin-producing cells encapsulated in silanized hydroxypropyl methylcellulose (Si-HPMC) for the treatment of type 1 diabetes. Methods and kits are also provided for restoring and/or maintaining euglycemia in type 1 diabetic patients and in type 1 prediabetic patients.Type: GrantFiled: November 10, 2016Date of Patent: April 28, 2020Assignees: Ecole Nationale Veterinaire, Chu Nantes, Universite de Nantes, Institute National de la Sante et de la Recherche MedicaleInventors: Jean-Marie Bach, Mathilde Mosser, Apolline Salama, Anne Moure, Xavier Leveque, Pierre Weiss, Jérôme Guicheux, Cécile Boyer, David Riochet
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Publication number: 20180318358Abstract: The present invention relates to the use of insulin-producing cells encapsulated in silanized hydroxypropyl methylcellulose (Si—HPMC) for the treatment of type 1 diabetes. Methods and kits are also provided for restoring and/or maintaining euglycemia in type 1 diabetic patients and in type 1 prediabetic patients.Type: ApplicationFiled: November 10, 2016Publication date: November 8, 2018Inventors: Jean-Marie BACH, Mathilde MOSSER, Apolline SALAMA, Anne MOURE, Xavier LEVEQUE, Pierre WEISS, Jérôme GUICHEUX, Cécile BOYER, David RIOCHET
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Publication number: 20180221493Abstract: The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.Type: ApplicationFiled: April 10, 2018Publication date: August 9, 2018Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Nantes, CHU NantesInventors: Pierre Weiss, Eva Mathieu, Jerome Guicheux, Patricia Lemarchand
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Patent number: 9968681Abstract: The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.Type: GrantFiled: June 4, 2012Date of Patent: May 15, 2018Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Nantes, CHU NantesInventors: Pierre Weiss, Eva Mathieu, Jérôme Guicheux, Patricia Lemarchand
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Patent number: 9285360Abstract: The invention concerns: —a silylated biomolecule having the following formula (I): —the process for the preparation of a silylated biomolecule of formula (I), —the use of a silylated biomolecule of formula (I) to functionalize the surface of a support, —a process for the preparation of a hydrogel by use of a silylated biomolecule of formula (I), the hydrogel obtainable by said process, —said hydrogel as a biological tissue substitute, —a composition comprising said hydrogel in a pharmaceutically acceptable vehicle, —said composition for the release of active principle.Type: GrantFiled: January 25, 2011Date of Patent: March 15, 2016Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Nantes, CHU Nantes, Institut Francais de Recherche pour l'Exploitation De la Mer—IFREMERInventors: Pierre Weiss, Jerome Guicheux, Gildas Rethore, Emile Rederstorff, Samia Laib
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Publication number: 20140161775Abstract: The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.Type: ApplicationFiled: June 4, 2012Publication date: June 12, 2014Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CHU NANTES, UNIVERSITE DE NANTESInventors: Pierre Weiss, Eva Mathieu, Jérôme Guicheux, Patricia Lemarchand
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Publication number: 20130336937Abstract: The invention provides chondrogenic differentiation media comprising chondrogenic growth factors and low-molecular-weight sulfated polysaccharide derivatives of marine native exopolysaccharides (EPS) excreted by mesophilic marine bacteria from deep-sea hydrothermal environments. The invention relates to methods for inducing chondrogenic differentiation in pluripotent or multipotent cells, to cartilage tissues obtained by such methods, and to the use of such cartilage tissues for therapeutic purposes.Type: ApplicationFiled: March 16, 2012Publication date: December 19, 2013Applicants: Institut National de la Sante et de Ia Recherche Medicale, UNIVERSITE DE NANTES, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MERInventors: Emilie Rederstorff, Corinne Sinquin, Jacqueline Ratiskol, Sylvia Colliec-Jouault, Jérome Guicheux, Pierre Weiss, Christophe Merceron
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Patent number: 8440462Abstract: The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.Type: GrantFiled: May 24, 2010Date of Patent: May 14, 2013Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de NantesInventors: Pierre Weiss, Jérôme Guicheux, Guy Daculsi, Gaël Grimandi, Claire Vinatier
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Publication number: 20130004460Abstract: The invention concerns: a silylated biomolecule having the following formula (I): the process for the preparation of a silylated biomolecule of formula (I), the use of a silylated biomolecule of formula (I) to functionalize the surface of a support, a process for the preparation of a hydrogel by use of a silylated biomolecule of formula (I), the hydrogel obtainable by said process, said hydrogel as a biological tissue substitute, a composition comprising said hydrogel in a pharmaceutically acceptable vehicle, said composition for the release of active principle.Type: ApplicationFiled: January 25, 2011Publication date: January 3, 2013Inventors: Pierre Weiss, Jerome Guicheux, Gildas Rethore, Emile Rederstorff, Samia Laib
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Patent number: 8044037Abstract: A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: GrantFiled: April 14, 2009Date of Patent: October 25, 2011Assignees: Centre National de la Recherche Scientifique, Université de Nantes, Institut National de la Santé et de la Recherche MédicaleInventors: Bruno Bujoli, Solen Josse, Jérôme Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
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Publication number: 20100297764Abstract: The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.Type: ApplicationFiled: May 24, 2010Publication date: November 25, 2010Inventors: Pierre Weiss, Jérôme Guicheux, Guy Daculsi, Gaël Grimandi, Claire Vinatier
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Publication number: 20090203648Abstract: A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: ApplicationFiled: April 14, 2009Publication date: August 13, 2009Applicants: Centre National de la Recherche Scientifique, Universite de Nantes, Institut National de la Sante et de la Recherche MedicaleInventors: Bruno Bujoli, Solen Josse, Jerome Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
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Patent number: 7521436Abstract: The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: GrantFiled: February 18, 2003Date of Patent: April 21, 2009Assignees: Centre National de la Recherche Scientifique, Universite de Nantes, Institut National de la Sante et de la Recherche MedicaleInventors: Bruno Bujoli, Solen Josse, Jérôme Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
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Patent number: 7351280Abstract: A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.Type: GrantFiled: February 9, 2005Date of Patent: April 1, 2008Assignees: New York University, Institut National Dela Sante ET Dela Recherche Medicale, The University of NantesInventors: Ibrahim Khairoun, Racquel Z. LeGeros, Guy Daculsi, Jean-Michael Bouler, Jérôme Guicheux, Olivier Gauthier
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Publication number: 20070212389Abstract: The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.Type: ApplicationFiled: November 4, 2004Publication date: September 13, 2007Inventors: Pierre Weiss, Jerome Guicheux, Guy Daculsi, Gael Grimandi, Claire Vinatier
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Publication number: 20050282783Abstract: The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: ApplicationFiled: February 18, 2003Publication date: December 22, 2005Applicant: Centre National de la Recherche ScientifiqueInventors: Bruno Bujoli, Solen Josse, Jerome Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
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Publication number: 20050199156Abstract: A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.Type: ApplicationFiled: February 9, 2005Publication date: September 15, 2005Inventors: Ibrahim Khairoun, Racquel LeGeros, Guy Daculsi, Jean-Michael Bouler, Jerome Guicheux, Olivier Gauthier