Abstract: Aspects of the disclosure include a natural language processing model by which topics of interest within a text are identified, such as by a predictive model that infers (e.g., based on scores associated with a text) a topic of interest associated with the text. The computer system may train or configure the prediction model, such as a machine learning model, to facilitate identification of topics of interest based on inputs, like one or more chunks of text, such as by keywords or phrases or combinations of keywords and associated metrics for nearness or frequency. The computer system may determine a measure of predicted impactfulness of the content item in relation to a topic of interest identified for the content item and determine whether to generate a notification transmitted to client devices of users having indicated the topic as of interest.

Abstract: Compositions comprising compounds that neutralize NK cell inhibitory receptors and methods of using such compositions in the treatment of hematological malignancies are provided.

Abstract: Compositions comprising compounds that neutralize NK cell inhibitory receptors and methods of using such compositions in the treatment of hematological malignancies are provided.

Abstract: The present invention relates to compositions an methods for regulating an immune response in a subject, particularly to treat a subject with a tumor, notably a solid tumor, or an infectious disease. Disclosed are methods of regulating the innate immunity in a subject, such as by regulating the activity of ?? T cells in a subject. Disclosed are combinations of particular agents, such as a cytokine and a ?? T cell activator, particular administration regimens and dosages can produce a remarkable expansion of ?? T cells in vivo and a remarkable increase in a subject's immune defense. The invention can be used for therapeutic purposes, to produce, regulate or facilitate an immune response in a subject.

Abstract: The present invention relates to compositions and methods useful for treating a cancer in mammals, including humans. The methods and compositions typically comprise use of a chemotherapeutic agent and a ?? T cell activator such that the composition is effective for treating a cancer. Preferably the composition enhances the effect of the ?? T cell activator and/or prevents or delays the escape of a tumor from control chemotherapy, particularly an anti-angiogenic chemotherapeutic agent.

Abstract: Methods for producing improved anti-human thymocyte immunoglobulins from specific-pathogen-free animals are provided, without the need for an adsorption step on human tissues and the consequent drawbacks of such a step.

Abstract: Methods for producing improved anti-human thymocyte immunoglobulins from specific-pathogen-free animals are provided, without the need for an adsorption step on human tissues and the consequent drawbacks of such a step.

Abstract: The present invention is directed to a vaccine adjuvant which improves the vaccine potency. More specifically, the present invention is directed to the use of a ??T lymphocyte activator as vaccine adjuvant to promote and enhance antigen specific immunological responses, as well as a vaccine composition comprising a ??T lymphocyte activator.

Abstract: The present invention relates to compositions and methods useful for treating a carcinoma or viral infection in mammals, including humans. The methods and compositions typically comprise use of an immunogenic or immunomodulatory compound, and a gamma delta T cell activator, such that the composition is effective for treating a carcinoma or viral infection. In a preferred aspect of the invention, the methods comprise use of a gamma delta T cell activator and a Mycobacterium antigen, which for example is an attenuated strain of Mycobacterium bovis (Bacillus Calmette-Guerin (BCG)).

Abstract: The present invention relates to compositions and methods for regulating an immune response in a subject, particularly to treat a subject with a tumor, notably a solid tumor, or an infectious disease. Disclosed are methods of regulating the innate immunity in a subject, such as by regulating the activity of ?? T cells in a subject. Disclosed are combinations of particular agents, such as a cytokine and a ?? T cell activator, particular regimens and dosages can produce a remarkable expansion of ?? T cells in vivo and a remarkable increase in a subject's immune defense. The invention can be used for therapeutic purposes, to produce, regulate or facilitate an immune response in a subject.

Abstract: Methods for producing improved anti-human thymocyte immunoglobulins from specific-pathogen-free animals are provided, without the need for an adsorption step on human tissues and the consequent drawbacks of such a step.

Abstract: A biocompatible, bioresorbable and nontoxic adhesive composition for surgical and/or therapeutic use, especially for the bonding of biological tissues to one another or to an implanted biomaterial, is provided which comprises at least one biodegradable macromolecular polyaldehyde of natural origin in aqueous solution and a collagen-based component dissolved in aqueous medium. A process for preparing this composition is also provided wherein these aqueous components are mixed together (e.g., at neutral, physiological pH) to give a gel which is rapidly applied to tissues and/or biomaterial to achieve binding. The present invention is advantageous in that it provides biodegradable macromolecular polyaldehydes with adhesive properties and the ability to be extremely well tolerated by the recipient while retaining their adhesive properties during their retention in the body.

Abstract: Biomaterial based on collagen comprises, intimately associated, a support forming a dermal substitute, said support comprising a layer based on type IV collagen and an epidermal epithelium having differentiated cells obtained by growing epidermal cells on said support.