Abstract: The invention relates to a three-wheeled electric vehicle (10) comprising a front-axle device (22) having two steerable front wheels (24a, 24b) which are aligned substantially parallel to each other when traveling straight ahead; a rear-axle device (12) with a driven rear wheel (14); and a vehicle frame (26) on which the front-axle device (22) and the rear-axle device (12) are supported; wherein the front-axle device (22) is designed such that when the steering angle is rotated, the vehicle frame (26) and the front wheels (24a, 24b) may be tilted in the direction of the rotated steering angle.

Abstract: The invention relates to a three-wheeled electric vehicle (10) comprising a front-axle device (22) having two steerable front wheels (24a, 24b) which are aligned substantially parallel to each other when traveling straight ahead; a rear-axle device (12) with a driven rear wheel (14); and a vehicle frame (26) on which the front-axle device (22) and the rear-axle device (12) are supported; wherein the front-axle device (22) is designed such that when the steering angle is rotated, the vehicle frame (26) and the front wheels (24a, 24b) may be tilted in the direction of the rotated steering angle.

Abstract: The invention pertains to the use of an apoptosis inducing combination of at least a. a first expression modulating compound silencing the expression of at least a first target gene involved in apoptosis and b. a second expression modulating compound silencing the expression of at least a second target gene involved in apoptosis as a positive control in expression modulating assays. Also provided are suitable methods, kits and compositions.

Abstract: The present in invention relates to a method for the separation of living cells from a mixture of dead and living cells which optionally can also possibly contain cell fragments.

Abstract: The invention pertains to the use of an apoptosis inducing combination of at least a. a first expression modulating compound silencing the expression of at least a first target gene involved in apoptosis and b. a second expression modulating compound silencing the expression of at least a second target gene involved in apoptosis as a positive control in expression modulating assays. Also provided are suitable methods, kits and compositions.

Abstract: The present invention relates to processes for the targeted transfection of cells, compositions which may be used for such processes, and corresponding pharmaceutical compositions for gene therapy. In particular, the invention relates to a process for introducing nucleic acid into cells comprising the steps of (a) mixing a nucleic acid with a dendrimer, in which a proportion of the dendrimer molecules are biotinylated; (b) mixing the resulting complex of nucleic acid and dendrimer with a second complex consisting of avidin or streptavidin and a biotinylated target-specific binding molecule; and (c) incubating the complex formed in step (b) with cells. Dendrimers which are well suited to the present invention include, for example, partially solvolysed polyamidoamine (PAMAM) dendrimers. Target-specific binding molecules are, in particular, cell-type-specific markers of the cell surface of the target cells.