Patents by Inventor Jörg J. Goronzy

Jörg J. Goronzy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for improving immune system function by administering agents that inhibit DNA-dependent protein kinase-directed apoptosis
    Patent number: 9511086
    Abstract: Methods and compositions for improving immune system function are provided. These methods find particular use in improving immune system function in individuals with a condition in which naïve lymphocytes comprise elevated amounts of DNA double strand breaks (DSB), for example, individuals with Rheumatoid Arthritis, individuals that have received a bone marrow transplant, or elderly individuals, e.g. individuals that are 50 or more years old. Also provided are methods and compositions for screening for novel compounds that will improve immune system function in such individuals.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: December 6, 2016
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Department of Veterans Affairs
    Inventors: Cornelia M. Weyand, Jörg J. Goronzy, Lan Shao
  • Biomarkers for the Diagnosis of Autoimmune Disease
    Publication number: 20120065140
    Abstract: Compositions and methods are provided for diagnosis and treatment of rheumatoid arthritis. Defects in T cell receptor signaling lower the activation threshold of RA T cells, thus predisposing for a failure in maintenance of immune tolerance. Overexpression of B-Raf and/or K-Ras in CD4 T cells lowers the threshold to respond to TCR triggering in the absence of costimulation and increases responses to citrullinated peptides and other autoantigens.
    Type: Application
    Filed: September 13, 2011
    Publication date: March 15, 2012
    Inventors: Jörg J. Goronzy, Cornelia M. Weyand
  • Immune System Function in Conditions Characterized by Elevated Double Strand Breaks
    Publication number: 20120039867
    Abstract: Methods and compositions for improving immune system function are provided. These methods find particular use in improving immune system function in individuals with a condition in which naïve lymphocytes comprise elevated amounts of DNA double strand breaks (DSB), for example, individuals with Rheumatoid Arthritis, individuals that have received a bone marrow transplant, or elderly individuals, e.g. individuals that are 50 or more years old. Also provided are methods and compositions for screening for novel compounds that will improve immune system function in such individuals.
    Type: Application
    Filed: August 8, 2011
    Publication date: February 16, 2012
    Inventors: Cornelia M. Weyand, Jörg J. Goronzy, Lan Shao