Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: One aspect is a method for producing a plurality of wire elements, including providing a metal wire, coating the metal wire with a first layer to obtain a first coated wire, subjecting the first coated wire to a first quality control process, marking any first defects identified in the first quality control process, coating the first coated wire with a further layer to obtain a further coated wire, and cutting the further coated wire to obtain a plurality of wire elements. Prior to cutting the further coated wire to obtain the plurality of wire elements, a first length of the first coated wire is less than 10% longer than a further length of the further coated wire.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: One aspect is a device for processing a filament in a process stream, including at least one processing beam source, designed and arranged for emitting at least one processing beam which is suitable for processing a segment of the filament by interaction of the at least one processing beam with the segment of the filament, thereby obtaining a processed filament. The device includes a guide, including a filament feed which is arranged upstream of the at least one processing beam source, and is designed to feed the filament from a feed reel. The guide is designed and arranged to guide the filament so that during the processing the segment of the filament inclines an angle with a vertical axis in the range from 0 to 45°.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: One aspect is a method for producing an ablated conductor, including providing a coated conductor including an inner layer that is electrically conducting and at least one coating layer that at least partially covers the inner layer, and providing at least one laser beam. The method includes at least partially removing the at least one coating layer in a first section by moving the at least one laser beam and the coated conductor with respect to each other along at least one scan line in the first section. A first energy density of a first radiation, produced by the at least one laser beam, that irradiates a surface of the first section is adjusted according to a first ablation depth of the first section.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: One aspect pertains to a method for producing an ablated wire, including providing a coated wire having a circumference and a length. The coated wire has a core, an outermost coating layer, and an outer surface. The outermost coating layer at least partially surrounds the core. A plurality of laser beams are provided. The coated wire and the plurality of laser beams are arranged with respect to each other. At least two of the plurality of laser beams are arranged at different angular positions with respect to the circumference of the coated wire. The outermost coating layer is at least partially removed by moving at least one of the plurality of laser beams with respect to the coated wire to obtain the ablated wire. At least two of the plurality of laser beams are independent of each other.

Abstract: The invention provides compositions comprising omega-3 fatty acid ethyl esters, specifically compositions that are based on semifluorinated alkanes. The compositions of the present invention may be topical ophthalmic compositions useful in the treatment of ocular diseases or conditions. The invention further provides kits comprising such compositions.

Abstract: One aspect is an ablation system with a wire feed configured to feed a wire and a wire take-up configured to take-up the wire. A wire handling system is configured to advance the wire and to stop the wire between the wire feed and the wire take-up in a controlled manner. A laser ablation processor is located between the wire feed and the wire take-up, the laser ablation processor having at least one laser configured to ablate the wire when the wire is stopped. A clamp system is located between wire feed and the wire take-up and configured to clamp onto the wire when the wire is stopped.

Abstract: One aspect relates to a method of manufacture of a composition, including providing a precursor formulation which includes at least silver chloride and an organic vehicle, wherein the precursor formulation includes agglomerates, and comminuting the precursor formulation, wherein the composition is obtained. One aspect further relates to a substrate which is at least partially coated with a coating including silver chloride, wherein the coating has an average size of agglomerates of 30 ?m or less, to an electrochemical sensor including at least one of these coated substrates and a use of the composition or a wire which is coated with the composition.

Abstract: One aspect is a method for producing a plurality of wire elements, including providing a metal wire, coating the metal wire with a first layer to obtain a first coated wire, subjecting the first coated wire to a first quality control process, marking any first defects identified in the first quality control process, coating the first coated wire with a further layer to obtain a further coated wire, and cutting the further coated wire to obtain a plurality of wire elements. Prior to cutting the further coated wire to obtain the plurality of wire elements, a first length of the first coated wire is less than 10% longer than a further length of the further coated wire.

Abstract: A control unit actuator assembly having a control unit and an actuator is provided with a sensor system which has a carrier body that is attachable to a component of the assembly in various angular positions.

Abstract: One aspect relates to a process for manufacturing an electrochemical sensor, including moving a metal wire from a wire feed unit to a wire pick-up unit, the moving wire passing at least one printer Pcond which is located in between the wire feed and wire pick-up units, and printing an ink which includes electrically conductive particles by the printer Pcond onto discrete arrays of an electrically insulating polymer coating which is present on the metal wire.

Abstract: The present invention relates to a drop dispenser (1), comprising: —a container part (1B) with an interior volume adapted to be partially filled with a liquid phase (2) and a gaseous phase (3) filling the remainder of the interior volume at ambient pressure, the container part (1B) having a displaceable section (1C), and —a dropper part (1A) in physical connection and in fluid communication with the interior volume of the container part (1B), comprising an outflow channel (5), connecting the interior volume of the container part (1B) to the environment; wherein the outflow channel (5) comprises —a first section (5a) having a proximal end (5ap) and a distal end (5ad), each end having the same or different inner diameter selected independently from each other in the range of 0.09 to 0.19 mm; and —a second section (5b) having a proximal end (5bp) and a distal end (5bd); the proximal end (5bp) having an inner diameter in the range of 1 to 3 mm; the distal end (5bd) having an inner diameter in the range of 0.

Abstract: One aspect is a device for processing a filament in a process stream, including at least one processing beam source, designed and arranged for emitting at least one processing beam which is suitable for processing a segment of the filament by interaction of the at least one processing beam with the segment of the filament, thereby obtaining a processed filament. The device includes a guide, including a filament feed which is arranged upstream of the at least one processing beam source, and is designed to feed the filament from a feed reel. The guide is designed and arranged to guide the filament so that during the processing the segment of the filament inclines an angle with a vertical axis in the range from 0 to 45°.

Abstract: One aspect refers to a method for preparing a processed filament, including providing a filament, which comprises a multitude of segments, which follow one another in a longitudinal direction of the filament, wherein each of the segments of the multitude of segments comprises a multitude of sections, which are disposed circumferentially around the filament; and processing the filament in n processing steps, thereby obtaining the processed filament. For each integer i in the range from 1 to n, the ith processing step comprises, for each integer j in the range from 1 to m, processing the jth section of the (i+j?1)th segment. N and m are integers which are, independent from one another, at least 2. Sections of different number are at different circumferential locations of the filament. The processing of each section of each segment of the filament comprises an interaction of the section of the segment of the filament with at least one processing beam.