Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.

Abstract: A process for producing solid dosage forms by forming a plastic mixture of at least one polymeric binder, at least one active ingredient and, where appropriate, conventional additives, and shaping the plastic mixture to the solid dosage forms using a mold, wherein an agent which modifies the surface properties is applied in finely divided form to the surface of the plastic, mixture during the shaping is described. The agent which modifies the surface properties is preferably a surfactant, a lipophilic compound, an antioxidant, a coloring agent or an agent with antistatic effect and/or lubricant effect.

Abstract: The invention relates to a process and an apparatus for producing solid dosage forms by molding plastic active ingredient-containing mixtures with use of a continuously operating molding tool with two parts which cooperate to mold the plastic mixture, with at least one part having a plurality of depressions to receive and mold the plastic mixture, wherein one part has at least two groups, which differ in volume and/or shape, of depressions. Dosage forms which differ in shape or size are obtained in one step.

Abstract: The present invention relates to formulations based on at least one heparin, glycosaminoglycan or heparinoid and on a formulation base with a lipid component and a polymer component. The use of this formulation as drug form for oral administration of at least one heparin, glycosaminoglycan or heparinoid, and also a process for producing the formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as drug form, advantageously using melt extrusion, are described. The lipid component advantageously has active ingredient-promoting properties, while the polymer component is soluble or swellable. At least parts of the lipid component are embedded in a polymer matrix, preferably in the form of a molecular dispersion. The formulations can form emulsions in water or aqueous liquids.

Abstract: Stable pharmaceutical preparations, comprising torasemide in noncrystalline form.

Abstract: The present invention relates to mechanically stable pharmaceutical presentations for oral administration, comprising in addition to one or more active ingredients and at least one melt-processable matrix-forming excipient more than 10 and up to 40% by weight of a surface-active substance with an HLB of from 2 to 18, which is liquid at 20° C. or has a drop point in the range from 20 to 50° C.

Abstract: Pieces of meat deep frozen to −5° C. to −20° C. in unit volumes and weight and without significant distortion of the muscle fiber structure are pressed in a mold to serving size portions in which the muscle structure is retained. The equal weight identical serving size portions can thus be automatically cooked for identical time periods and at identical temperature.

Abstract: Solvent-free noncrystalline bioactive substances are prepared from the corresponding crystalline bioactive substances in an extruder by melting the substances in the extruder under reduced pressure and in the absence of auxiliaries, cooling and comminuting.

Abstract: The present invention relates to an apparatus for producing solid active ingredient-containing forms from an active ingredient-containing formulation which comprises at least one polymeric binder. The apparatus according to the invention has at least one extruder 1 for continuous plastication of the formulation and at least two injection units 2 which are provided separate from one another, each of which is connected to the extruder 1, and through which the formulation can be injected into at least one mold 3.

Abstract: Solid, elongate dosage forms (10) with a long axis (11) and with a length (L) which is defined by projection of the ends (12, 13) of the dosage form to the long axis, where a cross-sectional area (14, 15, 16) oriented perpendicular to the long axis (11) has an area which is variable along the long axis (11) and increases from a cross-sectional area (15) which is located between the ends (12, 13) and has a minimal area essentially continuously toward the two ends (12, 13) up to in each case a cross-sectional area (14 and 16 respectively) with a maximal area, wherein the distance of the maximal cross-sectional area (14) which is located near one end (12) from the maximal cross-sectional area (16) which is located near the other end (13) is, projected on the long axis (11), more than half the length (L) of the dosage form (10), are described.

Abstract: A formulation based i) on lipoic acid or a physiologically acceptable salt thereof and, where appropriate, other active substances, and a formulation base having ii) a binder component and iii) where appropriate other physiologically acceptable excipients is described. Lipoic acid is in the form of a molecular dispersion in these formulations. An advantageous process for their preparation, in particular by melt extrusion, and the use of this formulation for oral administration of lipoic acid are likewise described.

Abstract: A cog belt has an elongated belt body formed with a multiplicity of longitudinally spaced transversely extending teeth along a longitudinal underside of the belt body and with at least one entrainer for a mold carriage on a longitudinal upper side of the belt body, and a pair of metal plates affixed to opposite lateral sides of the belt body in the region of the entrainer, each of the plates being secured to the entrainer and to at least one of the teeth in the region.

Abstract: A method for the residue-free subdivision of a parallelepipedic block of a deep-frozen foodstuff into small parallelepipedic portions of substantially identical format is performed by multistage sawing cuts. A conveyor system moves the block in a conveying direction, wherealong the block is initially subdivided into large thin slabs. The slabs, transported in the conveying direction of the sawing line, are then subdivided from above on a closed table top by circular saws equipped with very thin circular saw blades. The cutting loss during sawing is thereby minimized and the yield of portions optimized. Advantageously, any material accumulating during cutting is intercepted and applied to the deep-frozen foodstuff.

Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.

Abstract: In the subdivision of blocks of meat or fish, the pieces in the penultimate subdivision are joined end to end without a gap between them and then finally portioned into the smallest pieces which are shaped in a press. The result is a minimum amount of waste.

Abstract: The invention relates to a method and apparatus for the dejacketing of flat, parallelipipedic blocks packed in folding cartons. Dejacketing is performed in three steps. First the flaps provided overlapping one another on opposite sides are unfolded by being moved past unfolding tools. The blocks are then moved past a further unfolding tool which is disposed on the third narrow side and which unfolds the flaps provided at that place. In the third step the folding carton is seized by its lower flap on the third side and pulled downwards, the block being simultaneously advanced in the direction of its open third side, and the top side is stripped off at a fixed stripper.

Abstract: The invention relates to a portioning device for deep-frozen foodstuffs, more particularly fish. The portioning device is adapted to the portioning of parallelpipedic slabs (3). The slabs (3) are fed lying flat in the transverse position via a conveying path (6) to a drum (2) which is disposed above the conveying path (6) and whose generated surface (10) is equipped with heated separating webs (11, 12). The heated separating webs (11, 12) of the drum (2), which is driven in synchronism with the feed, subdivide the slab (3) in synchronism into individual portions (4,5). The shape of the portions (4,5) depends on the arrangement of the separating webs (11,12) on the drum generated surface (10). The subdivision of the slabs (3) into individual portions (4,5) is performed free from cutting losses, since the heated separating webs (11,12) soften up the deep-frozen foodstuffs at the cutting place.

Abstract: The invention relates to a saw band guide, comprising a supporting roller 3 supporting the saw band at its unserrated rear edge, and a guide fork 2 whose fork branches 2a, 2b, bearing hard metal plates 4a, 4b, form a guide gap in which the saw band 1 is guided laterally with its surface bearing against the hard metal plates 4a, 4b and which forms on the rear side an opening 2c into which sawn material stripped off by the hard metal plates 4a, 4b is conveyed.