Abstract: The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.

Abstract: The invention relates to a system for connecting rigid pipes and for connecting flexible pipes. The pipes have corresponding outer diameters, with a press jaw having a press contour, with at least one first fitting for press-fitting to a rigid pipe, the at least one first fitting having a first press sleeve with a first outer contour, with at least one second fitting for press-fitting to a flexible pipe, the at least one second fitting having a second press sleeve with a second outer contour, the at least one second fitting having a second press sleeve with a second outer contour has a second press sleeve with a second outer contour, the outer contour of the first press sleeve and the outer contour of the second press sleeve in each case being adapted at least in sections to the press contour of the press jaw of the press jaw and can be pressed by the press jaw and wherein the outer contours of the first press sleeve and of the second press sleeve correspond at least in sections.

Abstract: The invention relates to a system for producing a sealed connection of a press connector to a workpiece, in particular to a pipe, preferably to a plastic pipe, with a pressing tool for pressing a press connector and with a pressure tool for driving the pressing tool. The pressure tool is arranged to output a hydraulic pressure at a pressure generation point The pressing tool is arranged to receive a hydraulic pressure at a pressing location and to press a press connector accordingly. The pressure tool and the pressing tool are connected via a hydraulic pressure transmission connection, the pressure generation location and the pressing location being remote from each other. A corresponding method for producing a tight connection of a press connector to a workpiece, in particular to a pipe made of a flexible material, preferably a plastic pipe, as well as a press force translator and a press tool are also described.

Abstract: The invention relates to a system for producing a sealed connection of a press connector to a workpiece, in particular to a pipe, preferably to a plastic pipe, with a pressing tool for pressing a press connector and with a pressure tool for driving the pressing tool. The pressure tool is arranged to output a hydraulic pressure at a pressure generation point The pressing tool is arranged to receive a hydraulic pressure at a pressing location and to press a press connector accordingly. The pressure tool and the pressing tool are connected via a hydraulic pressure transmission connection, the pressure generation location and the pressing location being remote from each other. A corresponding method for producing a tight connection of a press connector to a workpiece, in particular to a pipe made of a flexible material, preferably a plastic pipe, as well as a press force translator and a press tool are also described.

Abstract: A pressing tool for pressing fittings to produce pipe connections, with two opposing pressing jaws, each having a pressing section and a lever section, and having a retaining element for swivel connecting the pressing jaws, wherein the pressing sections form a receiving section and wherein pressing the lever sections apart causes the receiving section to close. An actuator spindle, a spindle nut and at least two actuator levers are provided, and each actuator lever is swivel connected at one end to the lever section of a pressing jaw and each actuator lever is swivel connected at another end to the spindle nut. A method for pressing fittings for the production of pipe connections is also disclosed.

Abstract: The invention relates to a pressing tool for pressing fittings to produce pipe connections, with two opposing pressing jaws, each having a pressing section and a lever section, and having a retaining element for swivel connecting the pressing jaws, wherein the pressing sections form a receiving section and wherein pressing the lever sections apart causes the receiving section to close. The technical problem of pressing fittings to produce pipe connections in a simple and cost-effective manner is solved by the fact that an actuator spindle, a spindle nut and at least two actuator levers are provided, that each actuator lever is swivel connected at one end to the lever section of a pressing jaw and that each actuator lever is swivel connected at another end to the spindle nut. The invention also relates to a method for pressing fittings for the production of pipe connections.

Abstract: A press-in connecting piece for connecting a branch pipe to a pipe in the region of a branch opening. The connecting piece includes a pipe adapter having an inner opening, and a press-in nozzle having a pipe socket, wherein the pipe adapter has a sealing surface for resting in a sealing manner on the outer wall of the pipe, wherein the pipe socket has a tapering end portion remote from the pipe adapter.

Abstract: The invention is based on the technical problem of improving the pressing in of large press fittings, said problem being solved by a device for transmitting a mechanical force for driving a pressing device for press fittings, having a storage container (4) for hydraulic fluid, having a pump cylinder (8), having a working cylinder (12), having a first line (14) for connecting the storage container (4) to the pump cylinder (8), having a second line (16) for connecting the pump cylinder (8) to the working cylinder (12), and having a third line (18) for connecting the working cylinder (12) to the storage container (4), wherein means (20) for preventing a return flow into the storage container (4) are provided in the first line (14), wherein means (22) for preventing a return flow into the pump cylinder (8) are provided in the second line (16), wherein switching means (24) for opening and closing the third line (18) are provided, and wherein the swept volume (VA) of the working cylinder (12) is configured to be gr

Abstract: The invention is based on the technical problem of improving the pressing in of large press fittings, said problem being solved by a device for transmitting a mechanical force for driving a pressing device for press fittings, having a storage container (4) for hydraulic fluid, having a pump cylinder (8), having a working cylinder (12), having a first line (14) for connecting the storage container (4) to the pump cylinder (8), having a second line (16) for connecting the pump cylinder (8) to the working cylinder (12), and having a third line (18) for connecting the working cylinder (12) to the storage container (4), wherein means (20) for preventing a return flow into the storage container (4) are provided in the first line (14), wherein means (22) for preventing a return flow into the pump cylinder (8) are provided in the second line (16), wherein switching means (24) for opening and closing the third line (18) are provided, and wherein the swept volume (VA) of the working cylinder (12) is configured to be gr

Abstract: The invention is based on the technical problem of improving the pressing in of large press fittings, said problem being solved by a device for transmitting a mechanical force for driving a pressing device for press fittings, having a storage container (4) for hydraulic fluid, having a pump cylinder (8), having a working cylinder (12), having a first line (14) for connecting the storage container (4) to the pump cylinder (8), having a second line (16) for connecting the pump cylinder (8) to the working cylinder (12), and having a third line (18) for connecting the working cylinder (12) to the storage container (4), wherein means (20) for preventing a return flow into the storage container (4) are provided in the first line (14), wherein means (22) for preventing a return flow into the pump cylinder (8) are provided in the second line (16), wherein switching means (24) for opening and closing the third line (18) are provided, and wherein the swept volume (VA) of the working cylinder (12) is configured to be gr

Abstract: A jointing clamp for producing a compression joint, comprising: an upper jointing clamp half that can be pivoted about a first pivoting axis and has an upper main inlet contour, a lower jointing clamp half that can be pivoted about a second pivoting axis and has a lower main inlet contour, an upper contour element with an upper auxiliary inlet contour that cooperates with the upper jointing clamp half in such a way that a movement of the upper contour element is transmitted to the upper jointing clamp half and a lower contour element with a lower auxiliary inlet contour that cooperates with the lower jointing clamp half in such a way that a movement of the lower contour element is transmitted to the lower jointing clamp half. The invention furthermore relates to a corresponding method for producing a compression joint.

Abstract: A hole saw drill guide is described. The drill guide can be used when drilling holes in pipe or tubes. The hole saw drill guide includes a guide tube base assembly and an arbor shaft assembly. The guide tube base assembly is chained or otherwise secured to a pipe. The arbor shaft assembly is removably engaged with the guide tube base assembly and during use of the device, rotates within a guide tube of the base.

Abstract: A distribution valve with an integrated flowmeter unit, which exhibits a main flow channel, through which a medium can flow in a main flow direction, and a secondary flow channel branching from the latter. The distribution valve includes a distribution valve housing containing a main pipe, a first conduit pipe connection, a second conduit pipe connection and at least one branch lying in between. The main flow channel in the main pipe runs from the first conduit pipe connection to the second conduit pipe connection. The branch empties into a first housing part, which includes an outlet. The outlet of the first housing part empties into a second housing part, which accommodates a flowmeter body and includes an outlet that forms a third conduit pipe connection. The secondary flow channel runs from the at least one branch of the main pipe to the outlet of the second housing part.

Abstract: A hole saw drill guide is described. The drill guide can be used when drilling holes in pipe or tubes. The hole saw drill guide includes a guide tube base assembly and an arbor shaft assembly. The guide tube base assembly is chained or otherwise secured to a pipe. The arbor shaft assembly is removably engaged with the guide tube base assembly and during use of the device, rotates within a guide tube of the base.

Abstract: The invention relates to a press-in connecting piece for connecting a branch pipe to a pipe in the region of a branch opening, comprising a pipe adapter (6) having an inner opening (4), a press-in nozzle (10) having a pipe socket (8), wherein the pipe adapter (6) has a sealing surface (12) for resting in a sealing manner on the outer wall of the pipe, wherein the pipe socket (8) has a tapering end portion (14) remote from the pipe adapter (6). The invention also relates to a tool for fastening a press-in connecting piece on a pipe. The invention solves the technical problem of providing a press-in connecting piece and a tool which require a low installation effort and are thus more cost effective.

Abstract: A distribution valve with an integrated flowmeter unit, which exhibits a main flow channel, through which a medium can flow in a main flow direction, and a secondary flow channel branching from the latter. The distribution valve includes a distribution valve housing containing a main pipe, a first conduit pipe connection, a second conduit pipe connection and at least one branch lying in between. The main flow channel in the main pipe runs from the first conduit pipe connection to the second conduit pipe connection. The branch empties into a first housing part, which includes an outlet. The outlet of the first housing part empties into a second housing part, which accommodates a flowmeter body and includes an outlet that forms a third conduit pipe connection. The secondary flow channel runs from the at least one branch of the main pipe to the outlet of the second housing part.

Abstract: A jointing clamp for producing a compression joint, comprising: an upper jointing clamp half that can be pivoted about a first pivoting axis and has an upper main inlet contour, a lower jointing clamp half that can be pivoted about a second pivoting axis and has a lower main inlet contour, an upper contour element with an upper auxiliary inlet contour that cooperates with the upper jointing clamp half in such a way that a movement of the upper contour element is transmitted to the upper jointing clamp half and a lower contour element with a lower auxiliary inlet contour that cooperates with the lower jointing clamp half in such a way that a movement of the lower contour element is transmitted to the lower jointing clamp half. The invention furthermore relates to a corresponding method for producing a compression joint.