Abstract: The present invention relates to a CNNM4 inhibitor for use in the treatment of an acute or a chronic liver, kidney and/or lung disease in a subject, and to pharmaceutical compositions comprising a therapeutically effective amount of a CNNM4 inhibitor and a pharmaceutically acceptable excipient or carrier. Furthermore, the invention relates to a method for diagnosing a liver disease, a kidney disease or a lung disease in a subject, and to in vitro methods for identifying a compound potentially useful for reducing an induced CNNM4-mediated disease or condition in a cell.

Abstract: The invention relates to nucleic acid products that interfere with or inhibit CNNM4 (Cyclin M4) gene expression. It further relates to therapeutic uses of CNNM4 inhibition for the treatment of diseases, such as liver diseases including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver steatosis, liver fibrosis, liver cirrhosis, liver cancer and other diseases associated with magnesium dysregulation.

Abstract: A method and apparatus for collecting radiation by reflecting, redirecting, focusing, and transitioning the radiation, comprising providing a first reflective focusing surface, receiving full-spectrum light with the first surface, focusing the light onto a second reflective focusing surface after passing through a filtering surface, and allowing the two reflective surfaces to reflect visible light from one surface to the other and out an exit, while infrared light is minimized via the filtering surface.

Abstract: Moving metal strips can be heat treated with any number or combination of dimensionally variable tempers across widths, lengths, or thicknesses of a metal strip. To provide dimensionally variable heat treatment, an apparatus can include one or more heating units suitable to increase the temperature of a metal strip moving proximate the apparatus to a heat treatment temperature. The apparatus can also include one or more cooling units positioned near the heating units to absorb heat and cool the metal strip to minimize the amount of heat transferred from a first region of the metal strip that is to be treated to a second region of the metal strip that is not to be treated.

Abstract: The invention relates to nucleic acid products that interfere with or inhibit CNNM4 (Cyclin M4) gene expression. It further relates to therapeutic uses of CNNM4 inhibition for the treatment of diseases, such as liver diseases including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver steatosis, liver fibrosis, liver cirrhosis, liver cancer and other diseases associated with magnesium dysregulation.

Abstract: Moving metal strips can be heat treated with any number or combination of dimensionally variable tempers across widths, lengths, or thicknesses of a metal strip. To provide dimensionally variable heat treatment, an apparatus can include one or more heating units suitable to increase the temperature of a metal strip moving proximate the apparatus to a heat treatment temperature. The apparatus can also include one or more cooling units positioned near the heating units to absorb heat and cool the metal strip to minimize the amount of heat transferred from a first region of the metal strip that is to be treated to a second region of the metal strip that is not to be treated.

Abstract: The present invention relates to a CNNM4 inhibitor for use in the treatment of an acute or a chronic liver, kidney and/or lung disease in a subject, and to pharmaceutical compositions comprising a therapeutically effective amount of a CNNM4 inhibitor and a pharmaceutically acceptable excipient or carrier. Furthermore, the invention relates to a method for diagnosing a liver disease, a kidney disease or a lung disease in a subject, and to in vitro methods for identifying a compound potentially useful for reducing an induced CNNM4-mediated disease or condition in a cell.

Abstract: Disclosed are welds formed from improved resistance spot welding. Resistance spot welding includes positioning a first metal sheet and a second metal sheet between two electrodes, contacting the two electrodes together on to opposing surfaces of the first metal sheet and the second metal sheet, and applying at least a minimum current to the first metal sheet and the second metal sheet through the two electrodes to form a weld having a minimum weld size to join the first metal sheet with the second metal sheet. At least one of the first metal sheet and the second metal sheet is a fusion alloy where the composition of at least one outer layer of the sheet is different from the composition of the core of the sheet.

Abstract: Moving metal strips can be heat treated with any number or combination of dimensionally variable tempers across widths, lengths, or thicknesses of a metal strip. To provide dimensionally variable heat treatment, an apparatus can include one or more heating units suitable to increase the temperature of a metal strip moving proximate the apparatus to a heat treatment temperature. The apparatus can also include one or more cooling units positioned near the heating units to absorb heat and cool the metal strip to minimize the amount of heat transferred from a first region of the metal strip that is to be treated to a second region of the metal strip that is not to be treated.

Abstract: The invention relates to an electronic component (10) for an ID transmitter (100) of a vehicle, having at least one radio module (30) for communicating for an authorization request of the vehicle, wherein at least one near-field communication module (40) is provided for communicating in the near field (12) of the electronic component (10).

Abstract: Disclosed is a device (1, 30, 32, 38, 47, 55) for applying electrical pulses to pre-defined bodily tissue, which device can be placed on bodily surfaces of organisms.

Abstract: The invention relates to a method for displaying a piece of information, using a mobile ID transmitter (10) and a cellular telephone (20) having a display (21), wherein the mobile ID transmitter (10) is used to activate a security system of a motor vehicle, the mobile ID transmitter (10) has an electronics unit (11), the electronics unit (11) is used for data communication (30) with a vehicle-side device, a vehicle-side piece of information is transmitted from the vehicle-side device to the electronics unit (11) by means of the data communication (30), the vehicle-side piece of information is stored in a data memory (12), the electronics unit (11) communicates with the cellular telephone (20) by means of a communication connection (40), and the vehicle-side piece of information is transferred to the cellular telephone (20) by means of the communication connection (40) and displayed there by means of the display (21).

Abstract: The present invention provides for a hybrid solar radiation collection and distribution system comprising both passive solar and active solar components, generating electric potential, generating heat, and distributing visible light to numerous endpoints.

Abstract: The invention relates to a method for operating a control system (63) of a motorcycle (60), which moves an electromechanical steering lock (10) from an unlocked position (1) to a locked position (2) and vice-versa, with an ignition system (62) to start the engine of the motorcycle (60), which is controlled by the control system (63), an authentication (70), in which an ID-generator (64) maintains a data link with the control system (63), wherein after a positive authentication (70) in an operational step (71a,71b), the steering lock (10) is brought into the appropriate position (1,2). According to the invention, it is provided that the first actuator element (31) has a signal connection with the control system (63), which is accessible to the user, and the operational step (71a,71b) commences only after positive authentication (70) via intentional activation of the first actuator element (31), which occurs after the authentication (70).

Abstract: The invention relates to a method for controlling a blocking member (11) of a functional component (30), particularly of a steering column (30) of a motor vehicle, particularly of a motorcycle, having a drive (20) by which the blocking member (11) can be moved into a locking position (1) and into an unlocking position (2) and vice versa, wherein the blocking member (11) engages mechanically with the functional component (30) when in the locking position (1), releases from the functional component (30) when in the unlocking position (2), and the locking process is started via a defined triggering action on the part of the operator, the blocking member (11) being moved from the unlocking position (2) into the locking position (1) during said locking process.

Abstract: The invention relates to a device for actuating a locking member (10) of a functionally essential component (40), particularly a steering column (40) of a motor vehicle, having a gear box (20), being operatively connected to the locking member (10), wherein the locking member (10) can be moved into a locked position (1) and into a released position (2), and vice versa, wherein the locking member (10) engages into the functionally essential component (40) in the locked position (1), the locking member (10) is released from the functionally essential component (40) in the released position (2), an actuation device (30) is provided that can be accessed by a user, said actuation device being signal-connected to the gear box (20) during normal operation, by means of which an electronic actuation of the gear box (20) can be effected via an intentional actuation of the actuation device (30), said gear box moving the locking member (10) into the respective position (1, 2) thereof.

Abstract: The invention relates to a method for displaying a piece of information, using a mobile ID transmitter (10) and a cellular telephone (20) having a display (21), wherein the mobile ID transmitter (10) is used to activate a security system of a motor vehicle, the mobile ID transmitter (10) has an electronics unit (11), the electronics unit (11) is used for data communication (30) with a vehicle-side device, a vehicle-side piece of information is transmitted from the vehicle-side device to the electronics unit (11) by means of the data communication (30), the vehicle-side piece of information is stored in a data memory (12), the electronics unit (11) communicates with the cellular telephone (20) by means of a communication connection (40), and the vehicle-side piece of information is transferred to the cellular telephone (20) by means of the communication connection (40) and displayed there by means of the display (21).

Abstract: The invention relates to a method for controlling a blocking member (11) of a functional component (30), particularly of a steering column (30) of a motor vehicle, particularly of a motorcycle, having a drive (20) by which the blocking member (11) can be moved into a locking position (1) and into an unlocking position (2) and vice versa, wherein the blocking member (11) engages mechanically with the functional component (30) when in the locking position (1), releases from the functional component (30) when in the unlocking position (2), and the locking process is started via a defined triggering action on the part of the operator, the blocking member (11) being moved from the unlocking position (2) into the locking position (1) during said locking process.

Abstract: The invention relates to a mobile identification transmitter (10) of a security system for a keyless activation of a locking mechanism (43) of a motor vehicle (40), having a housing (11) in which an electronics unit (12) is disposed, having at least one transmitting and receiving unit (13), the transmitting and receiving unit (13) is in connection (42) with a connection unit in the motor vehicle, and where by means of the connection an identification test can be performed for determining the authorization of a user. According to the invention, the electronic unit (12) comprises a communication means (20) to enable a data transfer (25, 25?) to an external data device (30, 30?) only at a range of up to 10 cm.

Abstract: The invention relates to a mobile identification transmitter (10) in a safety system for a keyless activation of a locking apparatus (43) of a motor vehicle (40), with a housing (11) in which an electronic unit (12) with at least one transmitting and receiving unit (13) is arranged, which electronic unit (12) communicates with a communication unit (41) in the motor vehicle, by means of which an identification check for determining a user authorization can be performed. The invention provides that vehicle data from the motor vehicle (40) can be transmitted to the electronic unit (12), and that the electronic unit (12) comprises a connection means (20) for transmitting the vehicle data to an external data device (30).