Abstract: The invention relates to a dental restorative material which comprises (a) at least one antimicrobially active compound of Formula (I) [AG]m-R1—Z—SP—Y—R2—[WG]p??(I), or a filler that is surface-modified with at least one compound of Formula (I), (b) at least one radically polymerizable monomer and (c) at least one initiator for the radical polymerization. The invention also relates to a use of such dental restorative material for the preparation of an adhesive, primer, cement, coating material or filling material. The invention also relates to a dental material which comprises at least one compound of Formula (I), as well as a use of a compound of Formula (I) for modifying the surface of a substrate selected from ceramic materials, noble and non-noble metals, hard tooth structure, tooth enamel, dentine, collagen, soft tissue, mucous membrane and leather.

Abstract: The invention relates to a medicotechnical product having an antimicrobial finish of a complex material of metal nanoparticles and macromolecules, the macromolecules being formed at least partially from a polyamino acid.

Abstract: A membrane, especially for application in a sensor, which membrane includes a biocidal effect. The membrane comprises one or more components of the group consisting of: silver nano particles encapsulated in amphiphilic, core, shell structures, antimicrobial silanes, polymers with an antimicrobial end group, polyquads with modified end groups, and biocidally acting block copolymers. The membrane is resistant against aggressive agents, for example, corrosive or oxidizing cleaning agents, in the case of sterilizing, in the case of autoclaving, in the case of thermal loading and/or in the case of mechanical loading.

Abstract: The invention relates to a dental restorative material which comprises (a) at least one antimicrobially active compound of Formula (I) [AG]m-R1—Z—SP—Y—R2—[WG]p??(I), or a filler that is surface-modified with at least one compound of Formula (I), (b) at least one radically polymerizable monomer and (c) at least one initiator for the radical polymerization. The invention also relates to a use of such dental restorative material for the preparation of an adhesive, primer, cement, coating material or filling material. The invention also relates to a dental material which comprises at least one compound of Formula (I), as well as a use of a compound of Formula (I) for modifying the surface of a substrate selected from ceramic materials, noble and non-noble metals, hard tooth structure, tooth enamel, dentine, collagen, soft tissue, mucous membrane and leather.

Abstract: The invention relates to a medicotechnical product having an antimicrobial finish consisting of a complex material of metal nanoparticles and macromolecules, the macromolecules being at least partially formed from amphiphilically modified polyamino acids which contain amino acid units, which aside from the functional groups bonded in the peptide bond contain at least one further functional group and at least some of these groups are modified with substances bearing hydrophobic radicals via covalent bonds. The hydrophobic radicals are bonded by addition of substances bearing epoxy groups to the at least one further functional group and/or via at least one amino group of an amino acid unit bearing at least one amino group as a further functional group with maintenance of an amino function on the polyamino acids. The invention furthermore relates to the production of the complex material and of the medicotechnical product.

Abstract: The invention relates to hyper-branched polymers having a hydrophobic core and an antimicrobial and/or anti-adhesive active shell for providing surfaces with semi-permanent hygienic characteristics.

Abstract: Dental material which contains at least one compound of the formula [PG]m—R1—Z—SP—Y—R2—[WG]p, in which m=1, 2 or 3; p=1, 2 or 3; R1=is absent, a linear or branched C1 to C20 alkylene radical which can be interrupted one or more times by O, S, NH, SiR?, CONH CONR?, COO and/or OCONH, a substituted or unsubstituted, aromatic C6 to C14 radical or a combination thereof R2=is absent, a linear or branched C1 to C20 alkylene radical which can be interrupted one or more times by O, S, NH, SiR?, CONH CONR?, COO and/or OCONH, a substituted or unsubstituted, aromatic C6 to C14 radical or a combination thereof; PG=a radically polymerizable group; SP=a polymeric spacer which is selected from polyethylene glycol, polypropylene glycol, polyglycerol, polyalkyloxazoline, polyethyleneimine, polyacrylic acid, polymethacrylic acid, polyvinyl alcohol, polyvinyl acetate, poly-(2-hydroxyethyl)acrylate, poly-(2-hydroxyethyl)methacrylate groups, hydrophilic polypeptide groups and copolymers of the corresponding monomers; WG=antimicrob

Abstract: The invention relates to a medicotechnical product having an antimicrobial finish consisting of a complex material of metal nanoparticles and macromolecules, the macromolecules being at least partially formed from amphiphilically modified polyamino acids which contain amino acid units, which aside from the functional groups bonded in the peptide bond contain at least one further functional group and at least some of these groups are modified with substances bearing hydrophobic radicals via covalent bonds. The hydrophobic radicals are bonded by addition of substances bearing epoxy groups to the at least one further functional group and/or via at least one amino group of an amino acid unit bearing at least one amino group as a further functional group with maintenance of an amino function on the polyamino acids. The invention furthermore relates to the production of the complex material and of the medicotechnical product.

Abstract: Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating the surface with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner are bactericidal, i.e., they kill on contact up to 99% of deposited Gram-positive and Gram-negative bacteria, whether deposited through air or water.

Abstract: Novel solid phase reaction supports are disclosed. The solid phase reaction supports include (a) a solid phase carrier having a multiplicity of NH2 functional groups; (b) a coupling compound covalently bonded to an NH2 group of the solid phase carrier; and (c) a receptor compound coupled to the solid phase carrier through the coupling compound. The coupling compound is preferably ascorbic acid, dehydroascorbic acid or a diketo compound structurally similar to ascorbic acid or dehydroascorbic acid. The solid phase carrier is preferably made of cellulose.

Abstract: Novel solid phase reaction supports are disclosed. The solid phase reaction supports include (a) a solid phase carrier having a multiplicity of NH2 functional groups of the Formula (I): in which R1 and R2 are each H, or R1 is H and R2 is an alkyl or acyl substituent with a degree of substitution ≦1 or R1 is an alkyl or acyl substituent with a degree of substitution ≦1, and R2 is H, or R1 and R2 are each a substituent with a degree of substitution ≦2 and R3 is an aromatic substituent containing at least one free amino group having a substitution degree ≦1; (b) a coupling compound covalently bonded to an NH2 group of the solid phase carrier; and (c) a receptor compound coupled to the solid phase carrier through the coupling compound.