Patents by Inventor Jörg Vollmer

Jörg Vollmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180171338
    Abstract: The present invention relates generally to immunostimulatory nucleic acids, compositions thereof and methods of using the immunostimulatory nucleic acids. In particular the invention relates to palindrome-containing immunostimulatory nucleic acids and the use of these nucleic acids in treating disease.
    Type: Application
    Filed: February 5, 2018
    Publication date: June 21, 2018
    Applicant: Adiu Tide Pharmaceuticals GmbH
    Inventors: Eugen Uhlmann, Jörg Vollmer, Arthur M. Krieg, Ulrike Samulowitz, Bernard O. Noll
  • Patent number: 8304396
    Abstract: The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: November 6, 2012
    Assignees: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH, Pfizer Inc.
    Inventors: Arthur M. Krieg, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann, Marion Jurk, Grayson B. Lipford, Robert Rankin
  • Patent number: 8283328
    Abstract: The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: October 9, 2012
    Assignees: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Arthur M. Krieg, Grayson Lipford, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann, Marion Jurk, Robert Rankin
  • Patent number: 8188254
    Abstract: The invention relates to a class of CpG immunostimulatory oligonucleotides containing a CpG immunostimulatory motif and a second motif which is capable of forming secondary structure, including duplex and higher order structures, in vitro and in vivo. The oligonucleotides of the invention are useful as adjuvants in vaccination. The oligonucleotides are also useful for inducing an immune response, inducing expression of a type I interferon (IFN), inducing expression of gamma interferon (IFN-?), and for treating a variety of conditions, including allergy, asthma, infection, and cancer.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: May 29, 2012
    Assignees: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.
    Inventors: Eugen Uhlmann, Jörg Vollmer, Arthur M. Krieg, Bernhard O. Noll
  • Publication number: 20110206719
    Abstract: The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).
    Type: Application
    Filed: March 14, 2011
    Publication date: August 25, 2011
    Applicants: COLEY PHARMACEUTICAL GMBH, COLEY PHARMACEUTICAL GROUP, INC.
    Inventors: Alexandra Forsbach, Jörg Vollmer, Grayson B. Lipford
  • Publication number: 20110201672
    Abstract: The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infectious disease, such as hepatitis B and hepatitis C.
    Type: Application
    Filed: September 14, 2010
    Publication date: August 18, 2011
    Inventors: Arthur M. Krieg, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann
  • Patent number: 7998492
    Abstract: The invention provides methods for identifying and treating subjects having hepatitis C infections. In some instances, the subjects are those that are non-responsive to non-CpG therapy. Preferably, the subjects are treated with C class CpG immunostimulatory nucleic acids having a semi-soft backbone.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: August 16, 2011
    Assignees: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Navneet K. Ahluwalia, Susan M. Efler, Heather L. Davis, Jörg Vollmer
  • Publication number: 20110135605
    Abstract: The invention provides methods for identifying and treating subjects having hepatitis C infections. In some instances, the subjects are those that are non-responsive to non-CpG therapy. Preferably, the subjects are treated with C class CpG immunostimulatory nucleic acids having semi-soft backbone.
    Type: Application
    Filed: November 15, 2010
    Publication date: June 9, 2011
    Applicants: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Navneet K. Ahluwalia, Susan M. Efler, Heather L. Davis, Jörg Vollmer
  • Publication number: 20100316659
    Abstract: The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).
    Type: Application
    Filed: December 9, 2009
    Publication date: December 16, 2010
    Applicants: COLEY PHARMACEUTICAL GMBH, COLEY PHARMACEUTICAL GROUP, INC.
    Inventors: Alexandra Forsbach, Jörg Vollmer, Grayson B. Lipford
  • Publication number: 20100285041
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Application
    Filed: May 15, 2008
    Publication date: November 11, 2010
    Inventors: Eugen Uhlmann, Jörg Vollmer, Arthur Mertz Kreig
  • Patent number: 7795235
    Abstract: The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infectious disease, such as hepatitis B and hepatitis C.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: September 14, 2010
    Assignees: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann
  • Publication number: 20100183639
    Abstract: The invention relates to a nucleic acid-lipophilic conjugates and methods for modulating an immune response using the conjugates. The lipophilic moiety associated with an immunostimulatory nucleic acid.
    Type: Application
    Filed: November 10, 2009
    Publication date: July 22, 2010
    Applicants: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Eugen Uhlmann, Jörg Vollmer, Arthur M. Krieg
  • Patent number: 7662949
    Abstract: The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: February 16, 2010
    Assignees: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.
    Inventors: Alexandra Forsbach, Jörg Vollmer, Grayson B. Lipford
  • Publication number: 20090306177
    Abstract: Double-stranded short interfering ribonucleic acid (siRNA) are modified to reduce or eliminate their immunostimulatory effect without significantly affecting their gene silencing effect. Modified siRNA include one or more 2? sugar modifications and, optionally, internucleotide linkages on the sense strand. Compositions containing the modified siRNA and methods of making and using the modified siRNA are disclosed. New and previously characterized siRNA can be synthesized to incorporate modifications according to the invention.
    Type: Application
    Filed: September 15, 2006
    Publication date: December 10, 2009
    Applicants: Coley Pharmaceutical GmbH, Qiagen GmbH
    Inventors: Eugen Uhlmann, Marion Jurk, Joerg Vollmer, Christian Schetter, Martin Weber, Ioanna Andreou, Stefan Pitsch
  • Patent number: 7615539
    Abstract: The invention relates to a nucleic acid-lipophilic conjugates and methods for modulating an immune response using the conjugates. The lipophilic moiety associated with an immunostimulatory nucleic acid.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: November 10, 2009
    Assignees: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Eugen Uhlmann, Jörg Vollmer, Arthur M. Krieg
  • Patent number: 7566703
    Abstract: The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infectious disease, such as hepatitis B and hepatitis C.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: July 28, 2009
    Assignees: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Arthur M. Krieg, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann
  • Patent number: 7271156
    Abstract: The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: September 18, 2007
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical GmbH
    Inventors: Arthur M. Krieg, Jörg Vollmer, Christian Schetter