Abstract: This disclosure relates to ruxolitinib, or a pharmaceutically acceptable salt thereof, and its use in treating prurigo nodularis.

Abstract: A sensor line, which is configured to detect an ambient variable and which extends from a first end to a second end in a longitudinal direction, has a line core and a number of mutually spaced resistance elements with a resistance value. The resistance value varies depending on a value of the ambient variables. A measuring assembly having the sensor line is also provided.

Abstract: The invention relates to a method for producing a cable, comprising both a molding tool with a cavity and with at least one first opening, and a line, said line consisting of at least one wire and a sheath surrounding the at least one wire. According to the invention, the line is inserted into the cavity and is guided out of the cavity via at least the first opening. A molding compound is injected into the cavity of the molding tool in a pressurized manner, wherein the line is pressed onto a seal surface of the cavity by means of the pressure of the molding compound, and the line closes the cavity at the seal surface.

Abstract: An automatic measuring machine for automated determination of a respective density of a plurality of solid-state test pieces that includes a measuring arrangement with a dry weighing device and a wet weighing device. The measuring machine further includes a test piece magazine for holding the plurality of solid-state test pieces, and a feeding unit for feeding the solid-state test pieces from the test piece magazine to the measuring arrangement. The automatic measuring machine sequentially feeds the solid-state test pieces to the measuring arrangement by means of the feeding unit, to weigh the solid-state test pieces using the dry weighing device and the wet weighing device in order to obtain respective weighing measurement values for each solid-state test piece, and to determine a respective density value for each solid-state test piece on the basis of the respective weighing measurement values.

Abstract: The invention relates to a device (10) for shaping an elongated component (44), comprising: a shaping tool (12) that defines multiple molding points and delimits at least one cavity (20) in which the molding compound (18) introduced via the molding points can be received, at least one centering element (26) which is designed to receive an elongated component (22, 24) and guide same into the at least one cavity (20), wherein the at least one centering element (26) can be moved relative to the molding tool (12), and at least one drive device, by means of which the at least one centering element (26) can be driven so as to move relative to the molding tool (12).

Abstract: This disclosure relates to ruxolitinib, or a pharmaceutically acceptable salt thereof, and its use in treating prurigo nodularis.

Abstract: The invention relates to a method for producing a cable, comprising both a molding tool with a cavity and with at least one first opening, and a line, said line consisting of at least one wire and a sheath surrounding the at least one wire. According to the invention, the line is inserted into the cavity and is guided out of the cavity via at least the first opening. A molding compound is injected into the cavity of the molding tool in a pressurized manner, wherein the line is pressed onto a seal surface of the cavity by means of the pressure of the molding compound, and the line closes the cavity at the seal surface.

Abstract: The invention relates to an anti-corrosion agent with an aqueous base and a method for the production thereof. The water-based anti-corrosion agent is a cavity preservation agent, a means for underbody protection coating, a means for permanent storage and transport protection coating, or a means for temporary storage and transport protection coating, wherein the anti-corrosion agent is provided for anti-corrosion protection for a component, in particular a motor vehicle component, wherein the anti-corrosion agent can be applied cold, is reversibly gelling and physically drying, even in thick layers, is rheologically controllable and can be adjusted in an application-oriented manner.

Abstract: A method for producing an elongated article with a sheath. The sheath is extruded with a predetermined wall thickness in an extrusion unit. Following the extrusion unit in a feeding direction, a part of the still moldable material is built up with the aid of a molding unit during a molding process such that a molded part forms integrally on the sheath. The molding unit is moved according to the following working cycle: the molding unit is accelerated from a starting position in the feeding direction, then it is advanced in the direction of the elongated article and the molded part is formed, the molding unit is withdrawn from the elongated article, and the molding unit is decelerated and moved from an end position, counter to the feeding direction, back in the direction of the starting position.

Abstract: The invention relates to a device (10) for producing objects from a solidifying molding compound, comprising: a feed region (12) with at least one sprue point (32) for supplying the molding compound, and a mold insert (18), which at least in part bounds a cavity (36) in which the molding compound supplied through the sprue point (32) can be received, wherein the cavity (36) has at least one object molding region (38), which molds the object to be produced, and at least one distribution region (40), which is designed to guide the supplied molding compound to the object is molding region (38).

Abstract: The invention relates to a device (10) for shaping an elongated component (44), comprising: a shaping tool (12) that defines multiple molding points and delimits at least one cavity (20) in which the molding compound (18) introduced via the molding points can be received, at least one centering element (26) which is designed to receive an elongated component (22, 24) and guide same into the at least one cavity (20), wherein the at least one centering element (26) can be moved relative to the molding tool (12), and at least one drive device, by means of which the at least one centering element (26) can be driven so as to move relative to the molding tool (12).

Abstract: The present application provides methods of treating a disease selected from cutaneous lupus erythematosus (CLE) and Lichen planus (LP) in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a JAK1 selective inhibitor, or a pharmaceutically acceptable salt thereof.

Abstract: A method for producing an elongated product. By an extrusion unit, a material is extruded onto a core of the elongated product as a casing having a predetermined wall strength. Downstream of the extrusion unit and while the material is still moldable, the elongated product is supplied in a conveying direction to a molding unit. A portion of the material is held by the molding unit and, from the held material, a molded part is formed in an integral manner on the casing. The formation of the molded part is thereby carried out in an advantageous manner, via a deformation of material of the casing.

Abstract: A sensor line, which is configured to detect an ambient variable and which extends from a first end to a second end in a longitudinal direction, has a line core and a number of mutually spaced resistance elements with a resistance value. The resistance value varies depending on a value of the ambient variables. A measuring assembly having the sensor line is also provided.

Abstract: A stranding unit for a stranding machine has a stranding axis and a cage in which a number of baskets are arranged for receiving a number of reels having a strand material wound thereon. The stranding unit is characterized in that a stand is arranged which has a frame which extends around the cage in a circumferential direction around the stranding axis. The cage is mounted on the frame by a number of frame bearing elements and is rotatable around the stranding axis. As a result of the circumferential bearing, centrifugal forces are particularly efficiently distributed and absorbed by the frame during operation. In an advantageous further development, a plurality of basket are also mounted in a similar manner within the frame. The stranding unit as a whole is furthermore constructed such that it can be operated at a particularly high rotational speed.

Abstract: The invention relates to a device (10) for producing objects from a solidifying molding compound, comprising: a feed region (12) with at least one sprue point (32) for supplying the molding compound, and a mold insert (18), which at least in part bounds a cavity (36) in which the molding compound supplied through the sprue point (32) can be received, wherein the cavity (36) has at least one object molding region (38), which molds the object to be produced, and at least one distribution region (40), which is designed to guide the supplied molding compound to the object is molding region (38).

Abstract: The invention aims to increase concentricity compared to conventional centering methods in a 3D extrusion cycle, using a pressure-controlled or floating centering lance. The invention proposes a device (10) for moulding an elongate component (44), comprising: a moulding arrangement (12) with at least one gate point; and a mould insert (22) that can be received in said moulding arrangement (12) and displaced along a displacement axis (V) relative to the gate point (18), said mould insert (22) at least partly delimiting a cavity (28) in which a solidifying moulding compound (21) added via the gate point (18) can be received, and said device (10) additionally comprising a centering element (34) which is configured to receive an elongate component (44) and guide it along a centering axis (Z) into said cavity (28). The device (10) is also accompanied by a method for moulding an elongate component (44).

Abstract: A method for producing an elongated article with a sheath. The sheath is extruded with a predetermined wall thickness in an extrusion unit. Following the extrusion unit in a feeding direction, a part of the still moldable material is built up with the aid of a molding unit during a molding process such that a molded part forms integrally on the sheath. The molding unit is moved according to the following working cycle: the molding unit is accelerated from a starting position in the feeding direction, then it is advanced in the direction of the elongated article and the molded part is formed, the molding unit is withdrawn from the elongated article, and the molding unit is decelerated and moved from an end position, counter to the feeding direction, back in the direction of the starting position.

Abstract: A process produces an electrical line which extends in the longitudinal direction and the line has a line core and an outer shell. In a continuous shaping process, individual shell portions of the outer shell are formed successively by surrounding the line core with a curable plastic substance. In at least one portion, the outer shell is produced having a cross-sectional geometry which can be varied in the longitudinal direction of the line.

Abstract: A stranding unit for a stranding machine has a stranding axis and a cage in which a number of baskets are arranged for receiving a number of reels having a strand material wound thereon. The stranding unit is characterized in that a stand is arranged which has a frame which extends around the cage in a circumferential direction around the stranding axis. The cage is mounted on the frame by a number of frame bearing elements and is rotatable around the stranding axis. As a result of the circumferential bearing, centrifugal forces are particularly efficiently distributed and absorbed by the frame during operation. In an advantageous further development, a plurality of basket are also mounted in a similar manner within the frame. The stranding unit as a whole is furthermore constructed such that it can be operated at a particularly high rotational speed.