Abstract: Methods of inhibiting growth of a Plasmodium species, treating malaria, and inhibiting a glutathione S-transferase are provided. The methods include inhibiting growth of a Plasmodium species comprising contacting a Plasmodium species with a compound as disclosed herein. The methods also include treating malaria comprising administering a compound as disclosed herein to a human or animal patient, preferably a human patient, in need thereof. The methods further include inhibiting a glutathione S-transferase (GST) comprising contacting a GST with a compound as disclosed herein. Also provided are compounds for use in the disclosed methods.

Abstract: Described herein are methods of treating or preventing a fungal infection by administering one or more compounds of the present invention to a subject. The methods of the present invention treat or prevent a fungal infection of C. neoformans, C. gattii, L. prolificans, C. albicans, or a combination thereof, as examples. The compounds of the present invention may be administered to a subject with other agents such as antifungal agents.

Abstract: Described herein are methods of treating or preventing a fungal infection by administering one or more compounds of the present invention to a subject. The methods of the present invention treat or prevent a fungal infection of C. neoformans, C. gattii, L. prolificans, C. albicans, or a combination thereof, as examples. The compounds of the present invention may be administered to a subject with other agents such as antifungal agents.

Abstract: The present invention provides cell egress and invasion inhibitors and their use as antiparasitical agents.

Abstract: In one aspect, the present invention relates to a method of identifying compounds useful in modifying the activity of Aldolase.

Abstract: The present invention provides immunogenic compositions comprising one or more subtilisin-like protease 2 antigens, functional fragments or homologs thereof, from various Plasmodium species, methods, vectors comprising the antigens, and methods of use for the treatment of malaria and related disease.

Abstract: The present invention provides compounds or a pharmaceutically acceptable salts, solvates, stereoisomers, or prodrugs thereof which can block the Atg8-Atg3 protein-protein interaction, which is associated with autophagy in apicomplexan organisms. Pharmaceutical compositions comprising these compounds and their use for the suppression and treatment of various parasitical diseases are also provided.

Abstract: In one aspect, the present invention relates to a method of identifying compounds useful in modifying the activity of Aldolase.

Abstract: A switching device in particular for a vehicle has a switching lever which can be deflected into different switching positions to activate switching processes. An actuator is driven by a control device to cause the switching lever to vibrate, the control device receiving input signals from at least one other control device and determines therefrom a set conditions for admissible deflection of the switching lever. The actuator is driven by the control device when the switching lever is deflected from a respective switching position into a switching position which does not meet the set conditions.

Abstract: A switching device in particular for a vehicle has a switching lever which can be deflected into different switching positions to activate switching processes. An actuator is driven by a control device to cause the switching lever to vibrate, the control device receiving input signals from at least one other control device and determines therefrom a set conditions for admissible deflection of the switching lever. The actuator is driven by the control device when the switching lever is deflected from a respective switching position into a switching position which does not meet the set conditions.

Abstract: A steering column switch for a vehicle has a switch unit whose control lever is pivotably disposed in two transverse pivot planes which are preferably approximately perpendicular to each other and is coupled to switching members having switching contacts such that the switching contacts load the connecting contacts of a strip conductor support (20) in dependence on a working position of the control lever. A region of the control lever facing the switching members has contact points which are tapped by contact elements disposed on the switching member side to provide an electric connection to the strip conductor support. The ends of the contact elements facing the control lever load the contact points approximately at a right angle with respect to the strip conductor support and below a pivot axis of the control lever which extends parallel to the strip conductor support.

Abstract: A steering column switch for a vehicle has a switch unit whose control lever is pivotably disposed in two transverse pivot planes which are preferably approximately perpendicular to each other and is coupled to switching members having switching contacts such that the switching contacts load the connecting contacts of a strip conductor support (20) in dependence on a working position of the control lever. A region of the control lever facing the switching members has contact points which are tapped by contact elements disposed on the switching member side to provide an electric connection to the strip conductor support. The ends of the contact elements facing the control lever load the contact points approximately at a right angle with respect to the strip conductor support and below a pivot axis of the control lever which extends parallel to the strip conductor support.