Abstract: A microtiter plate, preferably in the form of an injection-molded part composed of plastic, having at least one first and one second fluid chamber, which are designed in particular as measurement chambers and are connected to one another by a fluid channel which, in cross section, is closed on all sides or all the way round, and the fluid channel is assigned a bubble trap, by way of which the movement of air or gas bubbles moving along a top wall, closing the fluid channel upwardly, of the fluid channel, in particular from the first to the second fluid chamber, can be stopped.

Abstract: Methods of controlling at least one multi-column chromatography arrangement for the continuous process of purifying biopharmaceuticals are provided. The methods include introducing a first multi-component mixture into a column of the multi-column chromatography arrangement; detecting at least one multivariate signal by at least one detector; calculating at least one process parameter on the basis of the multivariate signal by at least one data-processing program of a computing unit via application of a chemometric method; and controlling the purification process via control of at least one controllable control element on the basis of the at least one process parameter.

Abstract: The invention relates to a method for depositing samples in modules, in particular, in kits, in addition to an adapter. The inventive adapter (1) is embodied in such a manner that an injection needle can be received in a liquid-tight manner. It is connected in a liquid-tight manner to the low-lying module or kit (20) and enables a continuous flow of samples.

Abstract: The invention relates to a process for isolation of plasmid DNA from biomass by means of an aqueous 2-phase system having a polymer component and a salt component, characterized in that the resuspension of the biomass employed, the alkaline lysis of the biomass, the neutralization of the alkaline lysis batch and the separation of the plasmid DNA from the contaminants are carried out in a single reaction vessel (one-pot process) rendered possible in that the neutralization of the alkaline lysis batch is carried out in one and the same container by addition of potassium phosphate and one component of the aqueous 2-phase system is therefore already present. The second component of the aqueous 2-phase system is a PEG having a molecular weight of the mathematical average of about 600 g/mol to 1,000 g/mol.

Abstract: The invention relates to a method for depositing samples in modules, in particular, in kits, in addition to an adapter. The inventive adapter (1) is embodied in such a manner that an injection needle can be received in a liquid-tight manner. It is connected in a liquid-tight manner to the low-lying module or kit (20) and enables a continuous flow of samples.

Abstract: The invention relates to a process for selective, reversible adsorption of nucleic acids to a support material, which process is characterized in that (a) a nucleic acid-containing mixture having a cosmotropic salt content of at least 1 mole is contacted with said support material, whereupon the nucleic acid(s) is (are) adsorbed from said nucleic acid-containing mixture to said support material, and (b) the nucleic acid(s) bound to the support material is (are) detached from the support material by means of an aqueous solution having a salt content of no more than 1 mole.

Abstract: The invention relates to a method for stripping undesired nucleic acid components from double-stranded DNA, in particular, super-coiled plasmid DNA. The method according to the invention is characterised by the steps: (a) provision of a mixture containing completely and/or partly double-stranded nucleic acids and optionally single-stranded nucleic acids; (b) resuspension of the mixture from step (a) in an aqueous, low-molarity buffer system with low ionic strength and low buffer effect; (c) adjusting conditions in the mixture from step (b), under which the completely and/or partly double-stranded nucleic acids are denatured; (d) further addition of buffer and a polymer component to the mixture from step (c); (e) incubation of the mixture from step (d) for a time which is sufficient for the formation of an aqueous two-phase system with an upper and lower phase; and (f) removal of the upper phase containing the single-strand nucleic acid and collection of the double-strand nucleic acid from the lower phase.