Patents by Inventor Jürgen Klepp

Jürgen Klepp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10429382
    Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g. an enzyme, fluorescent or direct label etc.) wherein said conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e. which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: October 1, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Juergen Klepp
  • Publication number: 20170059564
    Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g. an enzyme, fluorescent or direct label etc.) wherein said conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e. which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
    Type: Application
    Filed: November 10, 2016
    Publication date: March 2, 2017
    Inventor: Juergen Klepp
  • Patent number: 9528986
    Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g. an enzyme, fluorescent or direct label etc.) wherein said conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e. which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: December 27, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Juergen Klepp
  • Publication number: 20150140582
    Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g. an enzyme, fluorescent or direct label etc.) wherein said conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e. which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
    Type: Application
    Filed: December 29, 2014
    Publication date: May 21, 2015
    Inventor: Juergen Klepp
  • Patent number: 8951806
    Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g., an enzyme, fluorescent or direct label, etc.) wherein the conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e., which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: February 10, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Juergen Klepp
  • Patent number: 8202490
    Abstract: A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: June 19, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Juergen Klepp, Thomas Fischer, Rolf Lerch, Dieter Mangold, Juergen Schaeffler
  • Publication number: 20110194980
    Abstract: A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
    Type: Application
    Filed: April 19, 2011
    Publication date: August 11, 2011
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Juergen Klepp, Thomas Fischer, Rolf Lerch, Dieter Mangold, Juergen Schaeffler
  • Patent number: 7955563
    Abstract: A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluid.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: June 7, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Juergen Klepp, Thomas Fischer, Rolf Lerch, Dieter Mangold, Juergen Schaeffler
  • Publication number: 20110091914
    Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g., an enzyme, fluorescent or direct label, etc.) wherein the conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e., which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
    Type: Application
    Filed: November 1, 2010
    Publication date: April 21, 2011
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventor: Juergen Klepp
  • Publication number: 20100330705
    Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g., an enzyme, fluorescent or direct label, etc.) wherein the conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e., which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
    Type: Application
    Filed: September 14, 2010
    Publication date: December 30, 2010
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventor: Juergen Klepp
  • Publication number: 20070274861
    Abstract: A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluid.
    Type: Application
    Filed: June 6, 2007
    Publication date: November 29, 2007
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Juergen Klepp, Thomas Fischer, Rolf Lerch, Dieter Mangold, Juergen Schaeffler
  • Publication number: 20070184506
    Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g., an enzyme, fluorescent or direct label, etc.) wherein the conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e., which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
    Type: Application
    Filed: January 12, 2007
    Publication date: August 9, 2007
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Juergen Klepp
  • Patent number: 7118875
    Abstract: The invention concerns an analytical element for the determination of an analyte containing in or on material which enables liquid transport between zones, a sample application zone and a detection zone located downstream thereof, wherein the detection zone contains a partner 1 of a specific binding pair 1 immobilized in such a manner that it is able to bind to partner 2 of the specific binding pair 1 which is not the analyte when it contacts it, wherein a labelled partner 1 of a specific binding pair 2 is present upstream of the detection zone impregnated on a material such that it can be detached by liquid and is able to bind to partner 2 of the specific binding pair 2 which is not the analyte when this contacts it as well as a method for the determination of an analyte using this analytical element.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: October 10, 2006
    Assignee: Roche Diagnostics GmbH
    Inventors: Jürgen Klepp, Gerhard Hiller, Alfons Nichtl, Thomas Fischer, Martina Hösch
  • Publication number: 20050202487
    Abstract: The present invention is directed to methods and kits for isolation of bacteria from biological samples. In such methods antibodies specific for eukaryotic cells, which are deficient in a bacteria-binding Fc-terminus, are used for separating eukaryotic cells from biological samples.
    Type: Application
    Filed: March 1, 2005
    Publication date: September 15, 2005
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Juergen Klepp, Peter Kaspar, Ralf Zielenski, Reiner Schlipfenbacher
  • Patent number: 6811971
    Abstract: The invention concerns a method for the detection of an infection with influenza A and/or influenza B virus comprising the steps: i) obtaining a saliva sample, ii) preparing the saliva sample for a detection reaction and iii) detecting the influenza A and/or influenza B virus in the saliva sample. The invention in addition concerns a test kit for the detection of an infection by the influenza A and/or influenza B virus containing: i) a device for the collection of a saliva sample and ii) reagents and auxiliary agents for the detection of influenza A and/or influenza B viruses. Furthermore the invention concerns the use of saliva as a sample material for the detection of an infection with the influenza A and/or influenza B virus.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: November 2, 2004
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Juergen Klepp, Reiner Schlipfenbacher
  • Patent number: 6703196
    Abstract: The invention concerns an analytical element for the determination of an analyte containing in or on material which enables liquid transport between zones, a sample application zone and a detection zone located downstream thereof, wherein the detection zone contains a partner 1 of a specific binding pair 1 immobilized in such a manner that it is able to bind to partner 2 of the specific binding pair 1 which is not the analyte when it contacts it, wherein a labelled partner 1 of a specific binding pair 2 is present upstream of the detection zone impregnated on a material such that it can be detached by liquid and is able to bind to partner 2 of the specific binding pair 2 which is not the analyte when this contacts it as well as a method for the determination of an analyte using this analytical element.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: March 9, 2004
    Assignee: Roche Diagnostics Corporation
    Inventors: Jürgen Klepp, Gerhard Hiller, Alfons Nichtl, Ulrike Fischer, Martina Hösch
  • Publication number: 20030143530
    Abstract: The invention concerns a method for the detection of an infection with influenza A and/or influenza B virus comprising the steps: i) obtaining a saliva sample, ii) preparing the saliva sample for a detection reaction and iii) detecting the influenza A and/or influenza B virus in the saliva sample. The invention in addition concerns a test kit for the detection of an infection by the influenza A and/or influenza B virus containing: i) a device for the collection of a saliva sample and ii) reagents and auxiliary agents for the detection of influenza A and/or influenza B viruses. Furthermore the invention concerns the use of saliva as a sample material for the detection of an infection with the influenza A and/or influenza B virus.
    Type: Application
    Filed: December 13, 2002
    Publication date: July 31, 2003
    Inventors: Juergen Klepp, Reiner Schlipfenbacher