Patents by Inventor Jürgen Malinka

Jürgen Malinka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160015781
    Abstract: The present invention is directed to a recombinant E. coli Nissle 1917 (EcN) cell transformed with a nucleic acid coding for a defensin protein or a derivative thereof. The invention is further directed to a pharmaceutical composition comprising this cell and a pharmaceutically acceptable carrier as well as a method of producing a recombinant E. coli Nissle 1917 cell and its use in the treatment of Crohn's disease.
    Type: Application
    Filed: February 14, 2013
    Publication date: January 21, 2016
    Inventors: Tobias Ölschläger, Ean Jeong Seo, Jan Wehkamp, Eduard F. Stange, Ulrich Sonnenborn, Jürgen Malinka, Hans Proppert
  • Patent number: 6833451
    Abstract: Lipopolysaccharides and processes for producting the lipopolysaccharides are provided. The lipopolysaccharide has a lipid A portion, a core oligosaccharide portion, and an O-specific chain having a single repeating unit 06. A lipopolysaccharide may be produced by washing and drying and E. coli bacterial mass, subjecting the washed and dried bacterial mass to a phenol/water extraction, and treating the extract with RNases, DNases, and proteinase K.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: December 21, 2004
    Assignee: Pharma-Zentrale GmbH
    Inventors: Hans Proppert, Jürgen Malinka, Jürgen Schulze, Ulrich Sonnenborn, Ulrich Zähringer, Artur Ulmer, Ernst Theodor Rietschel
  • Patent number: 6489107
    Abstract: Methods for identifying Escherichia coli strain DSM 6601 and nucleotide sequences associated therewith.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: December 3, 2002
    Assignee: Pharma-Zentrale GmbH
    Inventors: Jörg Hacker, Ulrich Sonnenborn, Gabriele Blum-Oehler, Jürgen Schulze, Jürgen Malinka, Hans Proppert
  • Patent number: 6391631
    Abstract: E. coli plasmids pMUT 1 and pMUT 2 containing DNA sequences exhibiting significant homologies to reduplicaton starting positions of other enterobacterial plasmids are disclosed. Also disclosed are expression vectors containing plasmicis pMUT1 and pMUT 2.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: May 21, 2002
    Assignee: Pharma-Zentral
    Inventors: Jörg Hacker, Ulrich Sonnen-Born, Jürgen Schulze, Gabrielle Blum-Oehler, Jürgen Malinka, Hans Proppert
  • Patent number: 6376185
    Abstract: The invention relates to DNA sequences from fimbrial gene clusters of Escherichia coli strain DSM 6601. This strain has two chromosomal fimbrial gene clusters, namely type I (fim) and FIC (foc) gene clusters. DNA sequences of the main subunits fimA and focA are represented by SEQ ID NOS: 1 and 2.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: April 23, 2002
    Assignee: Pharma-Zentrale GmbH
    Inventors: Jürgen Malinka, Jörg Hacker, Gabriele Blum-Oehler, Ulrich Sonnenborn, Jürgen Schulze, Hans Proppert