Patents by Inventor Jürgen Moll
Jürgen Moll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10018206Abstract: The invention relates to an impeller (1) for a fan, in particular an axial or radial fan having a hub (2) for connecting the impeller (1) to a drive motor and having fan blades (6) which are arranged circumferentially around the hub (2) and having pockets (9) in the hub region, having balance weights (15) which can be fastened therein, aligned in the axial direction. The balance weights (15) are made of U-shaped, bent weight clips made of spring-elastic material, having at least two opposite clip legs extending parallel to each other which are connected to each other via a bend section, and comprise a clamping gap between the clip legs. One of the clip legs extends within the pockets (9) and the other clip leg extends outside of the pockets (9), such that there is a clamping seat on a pocket wall (12) extending in the clamping gap.Type: GrantFiled: July 24, 2013Date of Patent: July 10, 2018Assignee: EBM-PAPST MULFINGEN GMBH & CO. KGInventors: Jürgen Moll, Christian Hammel
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Patent number: 9638214Abstract: A balancing weight to balance a blower wheel. The balancing weight is constructed in two pieces consisting of a spring clip and a supplemental weight. The spring clip features a retaining section for securing on the blower wheel and a receptacle section for mounting the supplemental weight.Type: GrantFiled: October 12, 2011Date of Patent: May 2, 2017Assignee: EBM-PAPST MULFINGEN GMBH & CO. KGInventors: Christian Hammel, Jürgen Moll
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Publication number: 20150233389Abstract: The invention relates to an impeller (1) for a fan, in particular an axial or radial fan having a hub (2) for connecting the impeller (1) to a drive motor and having fan blades (6) which are arranged circumferentially around the hub (2) and having pockets (9) in the hub region, having balance weights (15) which can be fastened therein, aligned in the axial direction. The balance weights (15) are made of U-shaped, bent weight clips made of spring-elastic material, having at least two opposite clip legs extending parallel to each other which are connected to each other via a bend section, and comprise a clamping gap between the clip legs. One of the clip legs extends within the pockets (9) and the other clip leg extends outside of the pockets (9), such that there is a clamping seat on a pocket wall (12) extending in the clamping gap.Type: ApplicationFiled: July 24, 2013Publication date: August 20, 2015Applicant: emb-papst Mulfingen GmbH & Co. KGInventors: Jürgen Moll, Christian Hammel
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Patent number: 8927530Abstract: The present invention provides a combination comprising (a) a compound of formula (I) and (b) one or more antineoplastic agents selected from the group consisting of an antimetabolite agent, analkylating or alkylating-like agent, an intercalating agent, a topoisomerase I or II inhibitor, an antimitotic agent, a kinase inhibitor, a proteasome inhibitor and an antibody inhibiting a growth factor or its receptor, wherein active ingredients of the combination are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate or solvate thereof, useful in the treatment of tumors.Type: GrantFiled: May 21, 2010Date of Patent: January 6, 2015Assignee: Nerviano Medical Sciences S.R.L.Inventors: Barbara Valsasina, Italo Beria, Antonella Ciavolella, Dario Ballinari, Enrico Pesenti, Juergen Moll, Mara Emanuela Casnaghi, Alessandro Luciano Croci
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Publication number: 20140234106Abstract: A balancing weight to balance a blower wheel. The balancing weight is constructed in two pieces consisting of a spring clip and a supplemental weight. The spring clip features a retaining section for securing on the blower wheel and a receptacle section for mounting the supplemental weight.Type: ApplicationFiled: October 12, 2011Publication date: August 21, 2014Inventors: Christian Hammel, Jürgen Moll
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Publication number: 20120114641Abstract: The present invention provides a combination comprising (a) a compound of formula (I) and (b) one or more antineoplastic agents selected from the group consisting of an antimetabolite agent, analkylating or alkylating-like agent, an intercalating agent, a topoisomerase I or II inhibitor, an antimitotic agent, a kinase inhibitor, a proteasome inhibitor and an antibody inhibiting a growth factor or its receptor, wherein active ingredients of the combination are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate or solvate thereof, useful in the treatment of tumors.Type: ApplicationFiled: May 21, 2010Publication date: May 10, 2012Applicant: NERVIANO MEDICAL SCIENCES S.R.L.Inventors: Barbara Valsasina, Italo Beria, Antonella Ciavolella, Dario Ballinari, Enrico Pesenti, Valter Domenico Croci, Mara Emanuela Casnaghi, Alessandro Luciano Croci, Juergen Moll
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Patent number: 8119641Abstract: Furo[3,2-c]pyrazole derivatives of formula (I) as defined in the description, and pharmaceutically acceptable salts thereof, wherein A is an aryl or heteroaryl ring, —NHZR5 is at the ortho position to the CONH linker; —R1 and R2 are the same or different and, independently from each other, represent a hydrogen atom, or an organic residue; R3 is a hydrogen or halogen atom or an organic group; R4 is a hydrogen or halogen atom or an organic group; Z is direct bond, >C?O, or —C(?O)NH—; —R5 is hydrogen or an optionally substituted organic group or isomers, tautomers, carriers, metabolites, prodrugs, and pharmaceutically acceptable salts thereof. A process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, in particular Aurora kinases activity or IGF-1R activity, like cancer.Type: GrantFiled: May 25, 2007Date of Patent: February 21, 2012Assignee: Nerviano Medical Sciences S.R.L.Inventors: Daniele Fancelli, Maurizio Pulici, Jürgen Moll, Tiziano Bandiera
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Patent number: 8084455Abstract: The invention provides low molecular weight compounds, namely tetrahydropyrrolo[3,4-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase.Type: GrantFiled: March 29, 2007Date of Patent: December 27, 2011Assignee: Nerviano Medical Sciences S.r.l.Inventors: Daniele Fancelli, Antonella Isacchi, Michele Modugno, Juergen Moll, Luisa Rusconi, Chiara Soncini, Rosita Lupi
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Publication number: 20110129467Abstract: The present invention provides a combination comprising a compound 1 of formula (A) and one or more antineo-plastic agents selected from the group consisting of an antibody inhibiting a growth factor or a receptor of the growth factor, a proteasome inhibitor or a derivative or prodrug thereof, and a kinase inhibitor or a derivative or prodrug thereof useful in the treatment of tumors.Type: ApplicationFiled: July 9, 2009Publication date: June 2, 2011Applicant: NERVIANO MEDICAL SCIENCES S.R.L.Inventors: Enrico Pesenti, Dario Ballinari, Juergen Moll
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Publication number: 20110117212Abstract: The present invention provides a therapeutic combination comprising (a) compound 1 of formula (A) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of platinum derivatives, antimetabolite agents, topoisomerase I inhibitors and antimicrotubule agents, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof.Type: ApplicationFiled: July 3, 2009Publication date: May 19, 2011Applicant: NERVIANO MEDICAL SCIENCES S.R.L.Inventors: Enrico Pesenti, Maurizio D'Incalci, Dario Ballinari, Juergen Moll
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Publication number: 20100035876Abstract: The invention provides low molecular weight compounds, namely tetrahydropyrrolo[3,4-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase.Type: ApplicationFiled: March 29, 2007Publication date: February 11, 2010Applicant: NERVIANO MEDICAL SCIENCES S.R.L.Inventors: Daniele Fancelli, Antonella Isacchi, Michele Modugno, Juergen Moll, Luisa Rusconi, Chiara Soncini, Rosita Lupi
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Publication number: 20100022553Abstract: The present invention provides a therapeutic combination comprising (a) a compound 1 of formula (A) as set forth in the specification and (b) a BCR-ABL kinase inhibitor selected from the group consisting of Imatinib, Dasatinib, Nilotinib, Bosutinib and Inno-406, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof.Type: ApplicationFiled: July 15, 2009Publication date: January 28, 2010Applicant: NERVIANO MEDICAL SCIENCES S.R.L.Inventors: Jürgen Moll, Dario Ballinari, Enrico Pesenti
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Patent number: 7582628Abstract: Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.Type: GrantFiled: August 11, 2006Date of Patent: September 1, 2009Assignee: Pfizer Italia S.r.l.Inventors: Daniele Fancelli, Barbara Forte, Jürgen Moll, Mario Varasi, Paola Vianello
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Patent number: 7141568Abstract: Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.Type: GrantFiled: July 1, 2004Date of Patent: November 28, 2006Assignee: Pfizer Italia S.r.l.Inventors: Daniele Fancelli, Barbara Forte, Jürgen Moll, Mario Varasi, Paola Vianello
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Publication number: 20040204477Abstract: A compound of formula (I) is provided which is able to interact with &bgr;-catenin/TCF-4 binding site, having a structure essentially equivalent to a pharmacophore (IA), as herein described.Type: ApplicationFiled: May 24, 2004Publication date: October 14, 2004Inventors: Juergen Moll, Stefan Knapp, Claudio Dalvit, Jean-Yves Trosset, Michael Sundstrom, Sergio Mantegani