Patents by Inventor Jürgen Mollenhauer
Jürgen Mollenhauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10539574Abstract: A method for the in vitro detection of cartilage tissue and/or for the in vitro determination of the purity of cartilage tissue includes: a) treating a tissue sample with a protease and b) testing the protease-treated tissue sample for the presence of protease-resistant fragments of type II collagen and/or type I collagen. Methods can be carried out for preparing a cartilage cell culture, and for preparing a cartilage cell-loaded implant. Protease-resistant fragments of type II collagen and/or type I collagen can be used for the in vitro detection of cartilage tissue and/or for the in vitro determination of the purity of cartilage tissue. A kit can be used for carrying out the methods.Type: GrantFiled: July 10, 2015Date of Patent: January 21, 2020Assignee: TETEC Tissue Engineening Technologies AGInventors: Karin Benz, Christian Freudigmann, Christoph Gaissmaier, Jochen Hecky, Jürgen Mollenhauer
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Patent number: 10500154Abstract: The invention relates to an injectable biocompatible composition based on a polymeric support as well as to a method for producing it, which composition which comprises at least one hydrophilic polymer, wherein the polymer is polymerizable in situ to form a gel, and wherein the hydrophilic polymer is crosslinkable serum albumin or crosslinkable serum protein. The composition can be used in the restoration, the reconstruction, and/or the replacement of tissues and/or organs, or as a drug release implant in mammals. The composition is particularly suitable for treating cartilage disorders of a diseased or injured articular site in a mammal.Type: GrantFiled: July 27, 2010Date of Patent: December 10, 2019Assignee: NMI NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGENInventors: Juergen Mollenhauer, Karin Benz, Barbara Platz, Helmut Wurst, Reinout Stoop
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In vitro method of predictive assessment of the prospects of success of an implant and/or transplant
Patent number: 9828636Abstract: An in vitro method of prognostically assessing tissue regeneration capacity and/or cellular potency and/or the prospects of success of an implantation and/or transplantation, wherein the transcriptome and/or the gene expression of cells, the gene expression originating from the transcriptome, are analyzed.Type: GrantFiled: March 20, 2014Date of Patent: November 28, 2017Assignee: TETEC Tissue Engineering Technologies AGInventors: Jürgen Mollenhauer, Christoph Gaissmaier, Karin Benz -
Publication number: 20170261515Abstract: A method for the in vitro detection of cartilage tissue and/or for the in vitro determination of the purity of cartilage tissue includes: a) treating a tissue sample with a protease and b) testing the protease-treated tissue sample for the presence of protease-resistant fragments of type II collagen and/or type I collagen. Methods can be carried out for preparing a cartilage cell culture, and for preparing a cartilage cell-loaded implant. Protease-resistant fragments of type II collagen and/or type I collagen can be used for the in vitro detection of cartilage tissue and/or for the in vitro determination of the purity of cartilage tissue. A kit can be used for carrying out the methods.Type: ApplicationFiled: July 10, 2015Publication date: September 14, 2017Inventors: Karin Benz, Christian Freudigmann, Christoph Gaissmaier, Jochen Hecky, Jürgen Mollenhauer
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Publication number: 20160046989Abstract: An in vitro method of prognostically assessing tissue regeneration capacity and/or cellular potency and/or the prospects of success of an implantation and/or transplantation, wherein the transcriptome and/or the gene expression of cells, said gene expression originating from the transcriptome, are analyzed.Type: ApplicationFiled: March 20, 2014Publication date: February 18, 2016Inventors: Jürgen Mollenhauer, Christoph Gaissmaier, Karin Benz
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Patent number: 9080213Abstract: A method of determining identity, purity and/or potency of chondrocytes in vitro includes a) isolating and, optionally, culturing chondrocytes from a biological sample, and b) determining gene expression of at least one marker in the chondrocytes selected from the group consisting of FLT-1, IL-1beta, BSP-2, and type I collagen.Type: GrantFiled: July 27, 2011Date of Patent: July 14, 2015Assignee: TETEC Tissue Engineering TechnologiesInventors: Juergen Mollenhauer, Christoph Gaissmaier
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Publication number: 20150080310Abstract: A biocompatible composition which comprises crosslinkable serum albumin, crosslinkable serum protein and/or crosslinkable derivatives derived therefrom, and which is polymerizable to give a hydrogel-forming material, is used in a method for the prevention of pathological adhesions.Type: ApplicationFiled: November 21, 2014Publication date: March 19, 2015Inventors: Larissa Lehmann, Elke Rist, Beate Scholz, Burkhard Schlosshauer, Juergen Mollenhauer, Christoph Gaissmaier
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Publication number: 20150038681Abstract: A method of preparing a product, preferably in the form of a functionalized high molecular weight component such as, for example, a functionalized protein includes passing a first liquid comprising a component A along one side of a semi-permeable membrane and passing a second liquid comprising a component B along another, preferably opposing, side of the membrane, wherein the membrane excludes passage of component A but allows passage of component B, and after passage of component B through the membrane, a chemical reaction takes place between component A and component B, preferably with the formation of covalent bonds.Type: ApplicationFiled: August 4, 2014Publication date: February 5, 2015Inventors: Juergen Mollenhauer, Heinz W. Joseph, Helmut Wurst
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Publication number: 20130210017Abstract: A method of determining identity, purity and/or potency of chondrocytes in vitro includes a) isolating and, optionally, culturing chondrocytes from a biological sample, and b) determining gene expression of at least one marker in the chondrocytes selected from the group consisting of FLT-1, IL-1beta, BSP-2, and type I collagen.Type: ApplicationFiled: July 27, 2011Publication date: August 15, 2013Applicant: TETEC - Tissue Engineering Technologies AktiengesellschaftInventors: Juergen Mollenhauer, Christoph Gaissmaier
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Publication number: 20120258147Abstract: The present invention relates to a method for inhibiting and/or preventing angiogenesis, the method comprising the step of administering a biocompatible composition, which is polymerizable to a hydrogel-forming material and which is based on a hydrophilic polymer, for inhibiting and/or preventing angiogenesis or endothelial cell proliferation, wherein the hydrophilic polymer is crosslinkable serum albumin or crosslinkable serum protein, in a subject in need of being treated. The invention furthermore relates to a method for inhibiting and/or preventing angiogenesis or endothelial cell proliferation in a subject in need thereof, comprising the step of administering a polymerized hydrogel-material, which has been obtained by polymerizing a serum-albumin- or serum-protein-based composition.Type: ApplicationFiled: April 18, 2012Publication date: October 11, 2012Applicant: NMI Naturwissenschaftliches und Medizinisches Institut an der Universitaet TuebingenInventors: Juergen Mollenhauer, Burkhard Schlosshauer, Beate Scholz
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Publication number: 20120039961Abstract: An implant includes a support material, cartilage cells and/or precursor cells thereof, and a cartilage-specific collagen type. A method for preparing the implant, to a therapeutic composition, includes cartilage cells and/or precursor cells thereof and a cartilage-specific collagen type. The implant and the therapeutic composition are suitable in particular for treating damage and/or diseases relating to the human and/or animal musculoskeletal system.Type: ApplicationFiled: April 16, 2010Publication date: February 16, 2012Applicant: TETEC TISSUE ENGINEERING TECHNOLOGIES AGInventor: Jürgen Mollenhauer
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Publication number: 20100322993Abstract: The invention relates to an injectable biocompatible composition based on a polymeric support as well as to a method for producing it, which composition which comprises at least one hydrophilic polymer, wherein the polymer is polymerizable in situ to form a gel, and wherein the hydrophilic polymer is crosslinkable serum albumin or crosslinkable serum protein. The composition can be used in the restoration, the reconstruction, and/or the replacement of tissues and/or organs, or as a drug release implant in mammals. The composition is particularly suitable for treating cartilage disorders of a diseased or injured articular site in a mammal.Type: ApplicationFiled: July 27, 2010Publication date: December 23, 2010Inventors: Juergen Mollenhauer, Karin Benz, Barbara Platz, Helmut Wurst, Reinout Stoop
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Publication number: 20040053919Abstract: The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the subject a therapeutically effective amount of an agent that attenuates annexin function. Also provided are various methods of screening for agents and genes that increase collagen synthesis, decrease collagen degradation, or reduce or delay apoptosis, and methods of using the identified agents or nucleic acids for attaining or maintaining cartilage homeostasis, promoting cartilage repair, increasing collagen synthesis, decreasing collagen degradation, or reducing or delaying apoptosis. The invention also provides methods of decreasing mineralization of vesicles derived from chondrocytes and of promoting endochondral bone growth using agents that attenuates annexin function.Type: ApplicationFiled: September 11, 2003Publication date: March 18, 2004Inventors: Susan Chubinskaya, Jeff Hutchins, Juergen Mollenhauer, Francis X. Tavares, Stephen A. Thomson, Jennings F. Worley
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Patent number: 6649366Abstract: The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the subject a therapeutically effective amount of an agent that attenuates annexin function. Also provided are various methods of screening for agents and genes that increase collagen synthesis, decrease collagen degradation, or reduce or delay apoptosis, and methods of using the identified agents or nucleic acids for attaining or maintaining cartilage homeostasis, promoting cartilage repair, increasing collagen synthesis, decreasing collagen degradation, or reducing or delaying apoptosis. The invention also provides methods of decreasing mineralization of vesicles derived from chondrocytes and of promoting endochondral bone growth using agents that attenuates annexin function.Type: GrantFiled: December 21, 2000Date of Patent: November 18, 2003Assignee: SmithKline Beecham CorporationInventors: Susan Chubinskaya, Jeff Hutchins, Juergen Mollenhauer, Francis X. Tavares, Stephen A. Thomson, Jennings F. Worley
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Patent number: 6577708Abstract: A method and system for detecting an image of an object, particularly a soft tissue material. A generated x-ray beam is transmitted through the soft tissue material. A transmitted beam is directed at an angle of incidence upon a crystal analyzer. An image of the object is detected from a beam diffracted from the crystal analyzer either at or near a peak of a rocking curve of the crystal analyzer. The method and system of this invention is particularly useful for analyzing images of cartilage.Type: GrantFiled: April 17, 2001Date of Patent: June 10, 2003Inventors: Leroy Dean Chapman, Moumen O. Hasnah, Oral Oltulu, Zhong Zhong, Juergen Mollenhauer, Carol Muehleman, Klaus Kuettner, Matthias Aurich, Etta D. Pisano, R. Eugene Johnston, William Craig Thomlinson, Dale Sayers
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Publication number: 20020052358Abstract: The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the subject a therapeutically effective amount of an agent that attenuates annexin function. Also provided are various methods of screening for agents and genes that increase collagen synthesis, decrease collagen degradation, or reduce or delay apoptosis, and methods of using the identified agents or nucleic acids for attaining or maintaining cartilage homeostasis, promoting cartilage repair, increasing collagen synthesis, decreasing collagen degradation, or reducing or delaying apoptosis. The invention also provides methods of decreasing mineralization of vesicles derived from chondrocytes and of promoting endochondral bone growth using agents that attenuates annexin function.Type: ApplicationFiled: December 21, 2000Publication date: May 2, 2002Inventors: Susan Chubinskaya, Jeff Hutchins, Juergen Mollenhauer, Francis X. Tavares, Stephen A. Thomson, Jennings F. Worley
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Publication number: 20020027970Abstract: A method and system for detecting an image of an object, particularly a soft tissue material. A generated x-ray beam is transmitted through the soft tissue material. A transmitted beam is directed at an angle of incidence upon a crystal analyzer. An image of the object is detected from a beam diffracted from the crystal analyzer either at or near a peak of a rocking curve of the crystal analyzer. The method and system of this invention is particularly useful for analyzing images of cartilage.Type: ApplicationFiled: April 17, 2001Publication date: March 7, 2002Inventors: Leroy Dean Chapman, Moumen O. Hasnah, Oral Oltulu, Zhong Zhong, Juergen Mollenhauer, Carol Muehleman, Klaus Kuettner, Matthias Aurich, Etta D. Pisano, R. Eugene Johnston, William Craig Thomlinson, Dale Sayers