Abstract: Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.

Abstract: The invention relates to new piperidine derivatives of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Abstract: A method and a display preparation unit are proposed for the execution of a transaction during which transaction data are processed which have to be confirmed by a user. The display preparation unit has a converter unit which converts transaction data to be interpreted into pixel values and displays them on a monitor, an interface of its own for directly attaching an input unit via which a user confirms displayed transaction data, as well as a crypto unit for generating a signature for a record of confirmed transaction data. In a variant the confirmation can be effected by the crypto unit generating and displaying a random number which has to be inputted by the user via a conventionally attached input unit.

Abstract: The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Abstract: The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Abstract: A method and a display preparation unit are proposed for the execution of a transaction during which transaction data are processed which have to be confirmed by a user. The display preparation unit (20) has a converter unit (29) which converts transaction data to be interpreted into pixel values and displays them on a monitor (6), an interface of its own for directly attaching an input unit (7) via which a user confirms displayed transaction data, as well as a crypto unit (31) for generating a signature for a record of confirmed transaction data. In a variant the confirmation can be effected by the crypto unit (31) generating and displaying a random number which has to be inputted by the user via a conventionally attached input unit (14).

Abstract: The invention relates to new piperidine derivatives of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Abstract: An electric machine (1), particularly used as an electric motor, has a rotor (2) comprising a plurality of disks (4). A disk (4) of the rotor (2) is divided in a circumferential direction (5) into a plurality of disk sectors (6, 7, 8) between which magnetic pockets (9, 10) are designed. Furthermore, the disk (4) has an inner fastening collar (15) and connecting members (20, 23, 24) connecting the disk sectors (6, 7, 8) to the fastening collar (15). Such a connecting member (20) comprises a main web (21), a side arm (30) branching off the main rib (21) in the circumferential direction (5), and a side arm (31) branching off the main web (21) opposite to the circumferential direction (5). High mechanical stability of the disk (4) can thus be ensured, wherein magnetic flow losses are reduced.

Abstract: The present invention relates to compounds of general formula I wherein the groups and radicals B, k, L, U, V, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.

Abstract: The present invention relates to compounds of general formula I wherein the groups and radicals B, k, L, U, V, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

Abstract: The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.

Abstract: A method for quantitating vitamin D metabolites directly in blood plasma or serum, without the need for prior purification of the vitamin D metabolites, comprising a digestion of the serum proteins with a serine protease such as proteinase K and sequence of steps for inhibiting the proteinase K activity in the competitive binding analysis. The advantages of this method are its high accuracy over the whole range of physiologically relevant values and that it can be easily adapted for a fully automated analysis of serum and plasma samples.

Abstract: The invention relates to a coolant pump (15) having a pump wheel (13) which is arranged on a pump wheel shaft (3, 11); and having a drive device (1; 8, 9) for the pump wheel (13), which drive device has a mechanical drive (1) and which drive device has an electric-motor drive (8, 9), wherein the pump wheel shaft is divided into a driving section (3) and a driven section (11), and an openable and closable clutch (4) is arranged between the driving section (3) and the driven section (11).

Abstract: The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R1 to R6 and X are as defined in Claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.

Abstract: Immunoassay for the determination of parathyroid hormone activity in a sample, and for the diagnosis, etiology and treatment of calcium metabolism disturbances, osteopathies and hyper- or hypoparathyroidisms. The parathyroid hormone activity is measured with the aid of an antibody which binds to an epitope in the region of the receptor binding structure 15 to 22 of the parathyroid hormone, and an antibody which recognizes whether the amino-terminal end 1 to 3 of the parathyroid hormone is intact. The assay permits the antagonistic characteristics of some parathyroid hormone fragments to be taken into account.

Abstract: The invention relates to an electric machine (1), in particular a synchronous machine, comprising a stator arrangement (3) having twelve stator teeth (2) and a rotor (6) having ten rotor poles (4). Said rotor poles (4) are separated by air gaps (9) and the rotor poles (4) are embodied as sinus poles.

Abstract: Method for determining the active parathyroid hormone content in a sample, wherein the component of parathyroid hormone polypeptide chains which are oxidized at one or more sites near the PTH receptor binding structure having the amino acids 15 to 22 are specifically excluded from the content determination. Oxidation of the parathyroid hormone occurs in particular in dialysis patients, their blood plasma being exposed to an oxidation stress in the dialysis. The invention is based on the use of antibodies which bind specific conformation epitopes of the oxidised or reduced parathyroid hormone and its fragments. Further, there is provided a test system for the quantitative determination of parathyroid hormone and active fragments hereof in a sample.

Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.

Abstract: The present invention relates to compounds of general formula I wherein the groups and radicals B, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.