Abstract: The present invention relates to a heat cabin with hot air extraction. In particular, it relates to a heat cabin (10) which is equipped with a heat supply and an exhaust air system, wherein the heat cabin (10) comprises support beams (42) and cladding panels (40) and the cladding panels (40) are aligned perpendicular to a wall or ceiling normal, and the exhaust air system comprises exhaust air openings (50) in the cladding panels (40), whose shape is determined by the support beams (42) and/or the cladding panels (40) and which have no through passage parallel to the wall or ceiling normal. Furthermore, it relates to a method for operating a heat cabin.

Abstract: A device for generating individual photons with energy E includes quantum emitters, having at least one determined transition with the energy E from an energy level N* to a lower energy level N1. The emitters are near a propagation path running from first to second regions. The device also includes at least one light source to output light, for propagation along the path. The light has the energy E for resonant excitation of the energy level N*. The emitters are arranged so that optionally exactly Z emitters are illuminated, forming an optical thickness ?>0 for the light along the path. The number Z lies in a range of Z0±10% and Z0 is a number at which a maximum destructive interference in the second region occurs between a two-photon component of the light scattered on the ZO emitters and a two-photon component of the non-scattered light.

Abstract: A device for generating individual photons with energy E includes quantum emitters, having at least one determined transition with the energy E from an energy level N* to a lower energy level N1. The emitters are near a propagation path running from first to second regions. The device also includes at least one light source to output light, for propagation along the path. The light has the energy E for resonant excitation of the energy level N*. The emitters are arranged so that optionally exactly Z emitters are illuminated, forming an optical thickness ?>0 for the light along the path. The number Z lies in a range of ZO±10% and ZO is a number at which a maximum destructive interference in the second region occurs between a two-photon component of the light scattered on the ZO emitters and a two-photon component of the non-scattered light.

Abstract: An optical diode (1) comprising an optical wave guide for guiding light, preferably of a light mode, with a vacuum wavelength ?0, wherein the optical wave guide has a wave guide core (2, 3, 14) with a first index of refraction (n1), and the wave guide core (2, 3, 14) is surrounded by at least one second optical medium which has at least one second index of refraction (n2), wherein n1>n2 applies, wherein the wave guide core (2, 3, 14) has at least in sections a smallest lateral dimension (7) which is a smallest dimension of a cross section (6) perpendicular to a propagation direction (5) of the light in the wave guide core (2, 3, 14), wherein the smallest lateral dimension (7) is greater than or equal to ?0/(5*n1) and less than or equal to 20*?0/n1, wherein the optical diode (1) additionally comprises at least one absorber element (10, 11, 15, 16) which is arranged in a near field, wherein the near field consists of the electromagnetic field of the light of the vacuum wavelength ?0 in the wave guide core (2

Abstract: An optical diode (1) comprising an optical wave guide for guiding light, preferably of a light mode, with a vacuum wavelength ?0, wherein the optical wave guide has a wave guide core (2, 3, 14) with a first index of refraction (n1), and the wave guide core (2, 3, 14) is surrounded by at least one second optical medium which has at least one second index of refraction (n2), wherein n1>n2 applies, wherein the wave guide core (2, 3, 14) has at least in sections a smallest lateral dimension (7) which is a smallest dimension of a cross section (6) perpendicular to a propagation direction (5) of the light in the wave guide core (2, 3, 14), wherein the smallest lateral dimension (7) is greater than or equal to ?0/(5*n1) and less than or equal to 20*?0/n1, wherein the optical diode (1) additionally comprises at least one absorber element (10, 11, 15, 16) which is arranged in a near field, wherein the near field consists of the electromagnetic field of the light of the vacuum wavelength ?0 in the wave guide core (2

Abstract: The present invention provides a method for preparation of a high concentration liquid formulation (HCLF) of an antibody or a fragment thereof. The present invention also relates to a method for stabilizing an anti-CD20 antibody or a fragment thereof in a liquid pharmaceutical formulation. Furthermore, the present invention relates to a liquid pharmaceutical formulation of a veltuzumab antibody or a fragment thereof comprising at least 155 mg/mL of a veltuzumab antibody or a fragment thereof.

Abstract: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase useful in the treatment of psoriasis or atopic dermatitis.

Abstract: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase useful in the treatment of psoriasis or atopic dermatitis.

Abstract: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase.

Abstract: A salt of (E)-N-{2-amino-phenyl)-3-{1-[4-(1-methyl-1 H-pyrazol-4-yl)-be?zenesulfonyl]-1 H-pyrrol-3-yl)-acrylamide selected from the group consisting of the hydrobromide, methansulfonate, hemi ethane-1,2-disulfonate, benzenesulfonate, toiuenesulfonate and 2-naphthalenesulfonate.

Abstract: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase.

Abstract: The compounds of a certain formula 1, in which R1, R7, R8, R9 and n have the meanings as given in the description, are novel effective inhibitors of the type 4 phosphodiesterase.

Abstract: Compounds of a certain formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.

Abstract: A salt of (E)-N-{2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-be?zenesulfonyl]-1H-pyrrol-3-yl)-acrylamide selected from the group consisting of the hydrobromide, methansulfonate, hemi ethane-1,2-disulfonate, benzenesulfonate, toiuenesulfonate and 2-naphthalenesulfonate.

Abstract: The invention relates to novel peptides, which can be used for the production of pharmaceutical compositions. These pharmaceutical compositions can be used for the treatment of edema, in particular pulmonary edema.

Abstract: The compounds of a certain formula 1, in which R1, R7, R8, R9 and n have the meanings as given in the description, are novel effective inhibitors of the type 4 phosphodiesterase.

Abstract: The invention relates to a catalyzer installation for spark-ignition engines which are operated with air/fuel ratios of .lambda.1, particularly for boat engines, the catalyzer being subdivided into a reduction part located upstream in the exhaust gas line and an oxidation part located coaxially downstream after it. An intermediate space is located between the reduction and oxidation parts. Both catalyzer parts are surrounded by a preferably cylindrical, water-cooled casing and the casing has a downstream secondary air inlet to which a secondary air blower can be connected, the secondary air separating the very hot catalyzer from the double-walled, water-cooled casing and, in particular, flowing round the oxidation catalyzer part in counterflow for air preheating so that the air preheated in this manner is passed through the intermediate space into the oxidation part. The catalyzer is accommodated in a cartridge which is supported in wire compression rings in the catalyzer casing.

Abstract: The present invention provides an isokinetic ergometer comprising a movement guide, power gripping points, a brake unit connected therewith and a speed regulator, characterized by the following features:(a) the power gripping points are mechanically connected with a piston movable in a cylinder,(b) a flow regulation valve is attached to the cylinder, and(c) the cylinder and flow regulation valve are hydraulically connected with one another via a pipe, the flow regulation valve regulating the length of the stroke.