Patents by Inventor Jürgen Wichmann

Jürgen Wichmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles
    Publication number: 20030225070
    Abstract: This invention relates to the treatment of mGluR5 receptor mediated disorders, which comprises administering to a person in need of treatment a compound having the formula 1
    Type: Application
    Filed: April 4, 2003
    Publication date: December 4, 2003
    Inventors: Vincent Mutel, Jens-Uwe Peters, Juergen Wichmann
  • Substituted imidazo [1,2-a] pyridine derivatives
    Publication number: 20030212096
    Abstract: The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount of a compound formula 1
    Type: Application
    Filed: April 4, 2003
    Publication date: November 13, 2003
    Inventors: Vincent Mutel, Jens-Uwe Peters, Juergen Wichmann
  • 1-Sulfonyl pyrrolidine derivatives
    Publication number: 20030212066
    Abstract: The present invention is a series of compounds that are derivatives of 1-sulfonyl-pyrrolidine and that demonstrate affinity towards metabotropic glutamate receptors. The invention further relates to medicaments containing these compounds and to a process for their preparation. The compounds possess affinity towards metabotropic glutamate receptors and are therefore useful in the treatment or prevention of acute and/or chronic neurological disorders.
    Type: Application
    Filed: March 26, 2003
    Publication date: November 13, 2003
    Inventors: Vincent Mutel, Juergen Wichmann
  • Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles
    Publication number: 20030208082
    Abstract: This invention relates to a compound and the use of the compound of the formula 1
    Type: Application
    Filed: March 25, 2003
    Publication date: November 6, 2003
    Inventors: Vincent Mutel, Jens-Uwe Peters, Juergen Wichmann
  • Di-or triaza-spiro [4,5] decane derivatives
    Patent number: 6642247
    Abstract: The present invention relates to compounds of the general formula wherein R1 is C6-10-cycloalkyl, optionally substituted by lower alkyl or —C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo[6.2.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: November 4, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Geo Adam, Andrea Cesura, François Jenck, Sabine Kolczewski, Stephan Röver, Jürgen Wichmann
  • Dihydro-benzo[b][1,4]diazepin-2-one derivatives
    Publication number: 20030166639
    Abstract: This invention relates to dihydro-benzo[b][1,4]diazepin-2-one derivatives of the formula 1
    Type: Application
    Filed: January 24, 2003
    Publication date: September 4, 2003
    Inventors: Geo Adam, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • Carbamic acid derivatives
    Patent number: 6596743
    Abstract: The present invention is a compound of formula: wherein R1, R2, R2′, X, A1/A2 and B are as defined in the specification. These compounds may be used in the control or prevention of acute and/or chronic neurological disorders such as restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregnancy, cardiac arrest, hypoglycaemia, Alzheimer's disease, Huntington's chorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, cognitive disorders, memory deficits, schizophrenia, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate deficiency functions, such as e.g. muscle spasms, convulsions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety, vomiting, acute and chronic pain, dyskinesia and depression.
    Type: Grant
    Filed: December 10, 2001
    Date of Patent: July 22, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Konrad Bleicher, Vincent Mutel, Eric Vieira, Jürgen Wichmann, Thomas Johannes Woltering
  • Substituted imidazo[1,2-A] pyridine derivatives
    Patent number: 6596731
    Abstract: The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount of a compound formula wherein R1 and R2 are selected from hydrogen, (C1-6)-alkyl, halogen, hydroxy, (C1-6)-alkoxy and A is defined the description, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: July 22, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Vincent Mutel, Jens-Uwe Peters, Juergen Wichmann
  • 1-sulfonyl pyrrolidine derivatives
    Patent number: 6589978
    Abstract: The present invention is a series of compounds that are derivatives of 1-sulfonyl-pyrrolidine and that demonstrate affinity towards metabotropic glutamate receptors. The invention further relates to medicaments containing these compounds and to a process for their preparation. The compounds possess affinity towards metabotropic glutamate receptors and are therefore useful in the treatment or prevention of acute and/or chronic neurological disorders.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: July 8, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Vincent Mutel, Juergen Wichmann
  • Method for treating conditions related to the glutamate receptor using carboxylic acid amide derivatives
    Patent number: 6548522
    Abstract: The present invention is concerned with the use of carbonylamino derivatives of the formula wherein R signifies lower alkyl, lower alkenyl, lower alkinyl, cycloalkyl, lower alkoxy or CF3; R1 signifies hydrogen or lower alkyl; R2 and R3 signify, independently from each other, hydrogen, halogen or nitro; Y signifies CH or N; n is 0-6; m is 0-2; as well as with their pharmaceutically acceptable salts for the treatment of diseases, which relate to metabotropic glutamate receptor antagonists and/or agonists.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: April 15, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Vincent Mutel, Eric Vieira, Juergen Wichmann
  • Dihydro-benzo [B] [1,4] diazepin-2-one derivatives
    Patent number: 6548495
    Abstract: This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula wherein R1, R2, R3 and Y are as defined in the specification. The invention includes pharmaceutical compositions containing these compounds, a process for their preparation and a method of treatment or prevention of acute and/or chronic neurological disorders by administering an effective amount of the compound of formula I or a pharmaceuticall acceptable salt thereof.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: April 15, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Geo Adam, Erwin Goetschi, Vincent Mutel, Juergen Wichmann, Thomas Johannes Woltering
  • Dihydro-benzo [b][1,4]diazepin-2-one derivatives
    Patent number: 6544985
    Abstract: This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula wherein R1, R2, R3, X and Y are as defined in the specification. The invention includes pharmaceutical compositions containing these compounds, a process for their preparation, their use in preparation of pharmaceutical compositions and administration of an effective amount of the compounds for the treatment or prevention of acute and/or chronic neurological disorders to a patient in need of such treatment.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: April 8, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Geo Adam, Erwin Goetschi, Vincent Mutel, Juergen Wichmann, Thomas Johannes Woltering
  • Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
    Publication number: 20030055042
    Abstract: The present invention is a compound of formula 1
    Type: Application
    Filed: April 9, 2002
    Publication date: March 20, 2003
    Inventors: Raffaello Masciadri, Andrew William Thomas, Juergen Wichmann
  • 4-aminopyrimidine derivatives
    Publication number: 20030022907
    Abstract: This invention is 4-aminopyrimidine derivatives of the formula 1
    Type: Application
    Filed: April 29, 2002
    Publication date: January 30, 2003
    Inventors: Vincent Mutel, Jens-Uwe Peters, Juergen Wichmann
  • Dihydro-benzo [b] [1,4] diazepin-2-one derivatives
    Publication number: 20020198197
    Abstract: This invention is a dihydro-benzo [b] [1,4] diazepin-2-one derivative of the formula 1
    Type: Application
    Filed: April 3, 2002
    Publication date: December 26, 2002
    Inventors: Geo Adam, Erwin Goetschi, Vincent Mutel, Juergen Wichmann, Thomas J. Woltering
  • Dihydro-benzo [b] [1,4] diazepin-2-one derivatives
    Publication number: 20020193367
    Abstract: This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula 1
    Type: Application
    Filed: April 3, 2002
    Publication date: December 19, 2002
    Inventors: Geo Adam, Erwin Goetschi, Vincent Mutel, Juergen Wichmann, Thomas Johannes Woltering
  • Substituted imidazo[1,2-A] pyridine derivatives
    Publication number: 20020188128
    Abstract: The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount of a compound formula 1
    Type: Application
    Filed: March 8, 2002
    Publication date: December 12, 2002
    Inventors: Vincent Mutel, Jens-Uwe Peters, Juergen Wichmann
  • Carbamic acid derivatives
    Patent number: 6462198
    Abstract: The present invention relates to compounds of formula wherein R1 signifies hydrogen or lower alkyl; R2, R2′ signify, independently from each other, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; X signifies O, S or two hydrogen atoms not forming a bridge; A1/A2 signify, independently from each other, phenyl or a 6-membered heterocycle containing 1 or 2 nitrogen atoms; B is a group of formula  wherein R3 signifies lower alkyl, lower alkenyl, lower alkinyl, benzyl, lower alkyl-cycloalkyl, lower alkyl-cyano, lower alkyl-pyridinyl, lower alkyl-lower alkoxy-phenyl, lower alkyl-phenyl, which is optionally substituted by lower alkoxy, or phenyl, which is optionally substituted by lower alkoxy, or lower alkyl-thienyl, cycloalkyl, lower alkyl-trifluoromethyl or lower alkyl-morpholinyl, Y signifies —O—, —S— or a bond; Z signifies —O— or —S—; or B is a 5-membered heterocyclic group of formulas
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: October 8, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Konrad Bleicher, Vincent Mutel, Eric Vieira, Jürgen Wichmann, Thomas Johannes Woltering
  • Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles
    Publication number: 20020128263
    Abstract: This invention relates to a compound and the use of the compound of the formula 1
    Type: Application
    Filed: November 28, 2001
    Publication date: September 12, 2002
    Inventors: Vincent Mutel, Jens-Uwe Peters, Juergen Wichmann
  • Substituted imidazo [1,5-a] [1,2,4] triazolo [4,3-d] [1,4] benzodiazepine derivatives
    Publication number: 20020103371
    Abstract: The present invention is a compound of formula 1
    Type: Application
    Filed: November 8, 2001
    Publication date: August 1, 2002
    Inventors: Raffaello Masciadri, Andrew W. Thomas, Juergen Wichmann