Abstract: Disclosed are systems and methods for a computerized framework that electronically manages and controls a patient's therapy for proper administration of diabetic treatment. The framework includes a disposable pen injector that has integrated therein dose logging capabilities (e.g., a NFC circuit) for controlling the administration of the prescribed therapy. Electronic communications between the disposable pen injector and a therapy control application executing on a patient's device can effectuate accurate and efficient administration of prescribed therapy. The pen can communicate information to the patient's device, and the application executing thereon, that includes dosage information related to availability left in the pen, timing of doses, and the like. In a related manner, the application can compile dosage planning information that can dictate types of doses, amounts of doses, timing of doses, and the like, to ensure that the patient is complying with a prescribed diabetic prescription.

Abstract: The disclosure provides driver components and methods of operating same that provide a reduced form factor for pen-type injection devices. In particular, various multi-piece telescoping plunger rod configurations are disclosed that can be implemented within pen-type injection devices to achieve such improvements. Driver components replace a single plunger rod having fixed length with telescoping pieces that are controlled to at least partially extend axially to dispense fluid from the reservoir or cartridge.

Abstract: An optical filter to increase contrast of an image generated with a spatial light modulator includes a lens for spatially Fourier transforming modulated light from the spatial light modulator, and an optical filter mask positioned at a Fourier plane of the lens to filter the modulated light. The modulated light has a plurality of diffraction orders, and the optical filter mask transmits at least one of the diffraction orders of the modulated light and block a remaining portion of the modulated light. A method that improves contrast of an image generated with a spatial light modulator includes spatially Fourier transforming modulated light from the spatial light modulator onto a Fourier plane, and filtering the modulated light by transmitting at least one diffraction order of the modulated light at the Fourier plane and blocking a remaining portion of the modulated light at the Fourier plane.

Abstract: A medical device for infusing medical substances has activation buttons accessible on an exterior of a device housing. The activation buttons and corresponding electrical switches within the device housing are configured to prevent inadvertent activation of the activation buttons and therefore inadvertent operation of the corresponding electrical switches to initiate a process such as the infusion of medical substance(s) to a user. The medical device employs overlap of respective time traces initiated by activation of the activation buttons to determine whether the activation is intended and valid. These respective time traces do not have to be initiated simultaneously or in any particular sequence. The activation buttons can be elastomeric overmolded buttons set within cutouts in the device housing, and, when depressed, make physical contact with the corresponding electrical switches.

Abstract: The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments. The present disclosure provides compounds of Formula (I).

Abstract: A rotary pump for a fluid metering system is provided. The rotary pump reciprocates, and is reversed by a signal from a limit switch that is deflected by an actuator arm on a rotating sleeve of the pump system.

Abstract: A medication delivery device includes an infusion pump system having a reservoir, a fluid path connected between the reservoir and an insertion mechanism, a plunger arranged inside the reservoir, and a pump drive mechanism coupled with the reservoir. The medication delivery device further includes a processing device configured to determine a user fill volume of a fluid medication by analyzing a location of the plunger inside the reservoir when a fill of the fluid medication is completed. The processing device is configured to determine the user fill volume of the fluid medication by sensing a pressure inside the reservoir.

Abstract: An aerosol dispensing system includes a container having a liquefied petroleum gas (LPG) composition disposed therein, and an overcap assembly having an actuator and an exit orifice, the overcap assembly being coupled to the container. The pest control composition is sprayed wherein the pest control composition is sprayed at a spray rate of between about 1.8 g/s and about 2.6 g/s and at a temperature of less than ?20° C. at least 18 inches from an exit orifice of the dispensing system.

Abstract: Dual or multi-modulation display system are disclosed that comprise projector systems with at least one modulator that may employ non-mechanical beam steering modulation. Many embodiments disclosed herein employ a non-mechanical beam steering and/or polarizer to provide for a highlights modulator.

Abstract: An apparatus is provided for detecting fluid low-volume and occlusion in a device using a sensor. One or more force sensing resistors are positioned in communication with a fluid channel at one or more of a pump intake and pump outlet to detect pressure in the fluid channel. The pressure is detected through communication with the force sensing resistor and indicates an irregular system condition including but not limited to, fluid low-volume level and occlusion. Also provided are a fluid flow sensor (e.g., FSR or MEMS sensor) disposed relative to an embedded fluid channel in the base of a wearable medicine delivery pump.

Abstract: A dual-modulation laser projection system (100) includes a polarizing beamsplitter (110) for splitting laser light (180) into first (182) and second (184) polarized beams having mutually orthogonal polarizations, a phase spatial light modulator (120) for beam steering the second polarized beam (184), a mechanical amplitude spatial light modulator (130) for amplitude modulating a combination of the first polarized beam (182) and the second polarized beam (186) as beam steered by the phase spatial light modulator (120), and a filter (140) for removing, from the combination (190) of the first and second polarized beams, one or more of a plurality of diffraction orders introduced by the mechanical amplitude spatial light modulator (130), to generate filtered, modulated output light (192).

Abstract: A novel projection system includes a base signal source, a highlight signal source, a base/highlight destination, and a shared optical element. A base signal provided by the base source and a highlight signal provided by the highlight source are combined by the shared optical element. In a particular embodiment, the base signal source and the highlight signal source each include a light source, a spatial light modulator, and optics, and the base/highlight destination includes optics and a spatial light modulator. In a more particular embodiment, the base signal source and the highlight source provide spatially modulated lightfields to the shared optical element. In another particular embodiment, the base signal and the highlight signal are modulated by the spatial light modulator of the base/highlight destination after being combined.

Abstract: Dual and multi-modulator projector display systems and techniques are disclosed. In one embodiment, a projector display system comprises a light source; a controller, a first modulator, receiving light from the light source and rendering a halftone image of said the input image; a blurring optical system that blurs said halftone image with a Point Spread Function (PSF); and a second modulator receiving the blurred halftone image and rendering a pulse width modulated image which may be projected to form the desired screen image. Systems and techniques for forming a binary halftone image from input image, correcting for misalignment between the first and second modulators and calibrating the projector system—e.g. over time—for continuous image improvement are also disclosed.

Abstract: Light from an array of laser light sources are spread to cover the modulating face of a DMD or other modulator. The spread may be performed, for example, by a varying curvature array of lenslets, each laser light directed at one of the lenslets. Light from neighboring and/or nearby light sources overlap at a modulator. The lasers are energized at different energy/brightness levels causing the light illuminating the modulator to itself be modulated (locally dimmed). The modulator then further modulates the locally dimmed lights to produce a desired image. A projector according to the invention may utilize, for example, a single modulator sequentially illuminated or separate primary color modulators simultaneously illuminated.

Abstract: Light projection systems using white light illumination. One embodiment provides a projection system using white light illumination. The projection system includes an illumination assembly configured to receive a white light input. A prism is configured to separate the white light input into color light inputs, redirect the color light inputs to respective modulators, and combine modulated color light inputs from the respective modulators into a white light output. An optical filter is configured to spatially Fourier transform the white light output to generate a filtered white light output. A projection lens assembly is configured to project the filtered white light output.

Abstract: A connector block that directs fuel from an outer fuel line to an inner fuel line. The connector block includes an inlet that couples to the outer fuel line, an outlet that coupled to the inner fuel line, and a fuel accumulator fluidly coupled to the inlet and the outlet. The fuel accumulator directs the fuel from the inlet to the outlet.

Abstract: A wearable unit is provided including a plurality of sensors including a temperature sensor configured to sense a temperature of a patient, a pulse oximeter configured to sense an oxygen saturation of the patient, an accelerometer configured to sense a breathing pattern of the patient, a skin conductance sensor configured to sense a skin conductance of the patient, and an electrocardiogram (ECG) monitor configured to sense an ECG pattern of the patient. The wearable unit may be configured to be worn on the patient's wrist or may be configured to be worn in the patient's ear. Information output by the sensors may be used to determine whether the patient is hyperglycemic or hypoglycemic and to provide an alert the patient or patient's caregiver. Information from the wearable unit may be wirelessly transmitted to an external device.

Abstract: A system and method is provided for detecting fluid low-volume and occlusion in a device using force sensing resistor (FSR) sensor. One or more force sensing resistors are positioned in communication with a fluid channel at one or more of a pump intake and pump outlet to detect pressure in the fluid channel. The pressure is detected through communication with the force sensing resistor and indicates an irregular system condition including but not limited to, fluid low-volume level and occlusion. Also provided are a fluid flow sensor (e.g., FSR or MEMS sensor) disposed relative to an embedded fluid channel in the base of a wearable medicine delivery pump.

Abstract: Dual or multi-modulation display systems comprising a first modulator and a second modulator are disclosed. The first modulator may comprise a plurality of analog mirrors (e.g. MEMS array) and the second modulator may comprise a plurality of mirrors (e.g., DMD array). The display system may further comprise a controller that sends control signals to the first and second modulator. The display system may render highlight features within a projected image by affecting a time multiplexing scheme. In one embodiment, the first modulator may be switched on a sub-frame basis such that a desired proportion of the available light may be focused or directed onto the second modulator to form the highlight feature on a sub-frame rendering basis.