Abstract: An audio processing system includes user-operable analog controls for real time control of audio, whose outputs are digitized synchronously with the audio to be controlled. Audio and control information sampling rates are 44.1 kHz or higher, resolution of the audio samples is 24-bit, and that of the control samples between 8-bit and 24-bit. Synchronous digitization of analog controller output may be used to control an arbitrary combination of digital and analog audio inputs. The described systems and methods eliminate lag and unresponsiveness experienced by audio control operators using conventional systems, particularly when using a cross-fader in DJ performance systems. The increased sample resolution preserves nuances of performer actions, and eliminates certain quantization artifacts.