Patents by Inventor Jörn Thilo WITSCH

Jörn Thilo WITSCH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-NET COMPOUNDS FOR TREATING AND PREVENTING FIBROSIS AND FOR FACILITATING WOUND HEALING
    Publication number: 20230190886
    Abstract: Embodiments of the technology described herein are based, in part, upon the discovery that NETosis, the formation of neutrophil extracellular traps (NETs) is increased in wounds, in organ fibrosis and in subjects with diabetes. Accordingly, methods for treating wounds, fibrosis and NET associated complications in diabetes are provided. The methods comprise administrating a therapeutically effective amount of at least one anti-NET compound to a subject in need of treatment, e.g. a PAD 4 inhibitor, a DNase, a histone-degrading enzyme; an inhibitor of chromatin decondensation; an antibody against a component of a NET; an inhibitor of NET release, a protease inhibitor, or an elastase inhibitor.
    Type: Application
    Filed: June 24, 2022
    Publication date: June 22, 2023
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Denisa D. WAGNER, Siu Ling WONG, Kimberly Lindsay MARTINOD, Luise ERPENBECK, Jörn Thilo WITSCH, Alexander SAVCHENKO
  • Anti-NET compounds for treating and preventing fibrosis and for facilitating wound healing
    Patent number: 11400139
    Abstract: Embodiments of the technology described herein are based, in part, upon the discovery that NETosis, the formation of neutrophil extracellular traps (NETs) is increased in wounds, in organ fibrosis and in subjects with diabetes. Accordingly, methods for treating wounds, fibrosis and NET associated complications in diabetes are provided. The methods comprise administrating a therapeutically effective amount of at least one anti-NET compound to a subject in need of treatment, e.g. a PAD 4 inhibitor, a DNase, a histone-degrading enzyme; an inhibitor of chromatin decondensation; an antibody against a component of a NET; an inhibitor of NET release, a protease inhibitor, or an elastase inhibitor.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: August 2, 2022
    Assignee: The Children's Medical Center Corporation
    Inventors: Denisa D. Wagner, Siu Ling Wong, Kimberly Lindsay Martinod, Luise Erpenbeck, Jörn Thilo Witsch, Alexander Savchenko
  • ANTI-NET COMPOUNDS FOR TREATING AND PREVENTING FIBROSIS AND FOR FACILITATING WOUND HEALING
    Publication number: 20180271953
    Abstract: Embodiments of the technology described herein are based, in part, upon the discovery that NETosis, the formation of neutrophil extracellular traps (NETs) is increased in wounds, in organ fibrosis and in subjects with diabetes. Accordingly, methods for treating wounds, fibrosis and NET associated complications in diabetes are provided. The methods comprise administrating a therapeutically effective amount of at least one anti-NET compound to a subject in need of treatment, e.g. a PAD 4 inhibitor, a DNase, a histone-degrading enzyme; an inhibitor of chromatin decondensation; an antibody against a component of a NET; an inhibitor of NET release, a protease inhibitor, or an elastase inhibitor.
    Type: Application
    Filed: January 19, 2016
    Publication date: September 27, 2018
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Denisa D. WAGNER, Siu Ling WONG, Kimberly Lindsay MARTINOD, Luise ERPENBECK, Jörn Thilo WITSCH, Alexander SAVCHENKO