Patents by Inventor J. Samuel Zigler

J. Samuel Zigler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxylamine compositions for the prevention or retardation of cataracts
    Patent number: 6001853
    Abstract: A pharmaceutical composition and treatment to inhibit the development of cataracts in the crystalline lens of the eye by administering a hydroxylamine to a subject at risk of developing a cataract. The pharmaceutical composition comprises a hydroxylamine compound in a therapeutically sufficient amount to prevent or retard the development of the cataract. A reducing agent can also be administered in combination with the hydroxylamine. Particular examples of the hydroxylamine are TEMPOL-H, TEMPO-H and OXANO-H, while particular examples of the reducing agent are a sulfhydryl compound, such as N-(2-mercaptopropionyl)glycine (MPG), N-acetyl cysteine, .beta.-mercaptopropionyl glycine, and glutathione. In particular embodiments, the composition comprises TEMPOL-H in an amount that is sufficient to provide a concentration of about 1 .mu.M to 1 mM in the aqueous humor of the eye, and mercaptopropionyl glycine in an amount sufficient to provide an aqueous humor concentrations of about 0.1 to 5 mM.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: December 14, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: J. Samuel Zigler, Paul Russell, Santa Tumminia, Chuan Qin, C. Murali Krishna