Patents by Inventor J. Scott Moncrief

J. Scott Moncrief has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to produce high levels of C. difficile toxins
    Patent number: 6939548
    Abstract: The present invention relates to the field of medical immunology and further to pharmaceutical compositions, methods of making and methods of use of vaccines. More specifically this invention relates to recombinant proteins derived from the genes encoding Clostridium difficile toxin A and toxin B, and their use in an active vaccine against C. difficile.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: September 6, 2005
    Assignee: Techlab, Inc.
    Inventors: Tracy D. Wilkins, David M. Lyerly, J. Scott Moncrief, Limin Zheng, Carol Phelps
  • Recombinant toxin A/toxin B vaccine against Clostridium difficile
    Patent number: 6733760
    Abstract: The present invention relates to the field of medical immunology and further to pharmaceutical compositions, methods of making and methods of use of vaccines. More specifically this invention relates to recombinant proteins derived from the genes encoding Clostridium difficile toxin A and toxin B, and their use in an active vaccine against C. difficile.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: May 11, 2004
    Assignee: Techlab, Inc.
    Inventors: Tracy D. Wilkins, David M. Lyerly, J. Scott Moncrief, Limin Zheng, Carol Phelps
  • Methods to produce high levels of C. difficile toxins
    Publication number: 20030129198
    Abstract: The present invention relates to the field of medical immunology and further to pharmaceutical compositions, methods of making and methods of use of vaccines. More specifically this invention relates to recombinant proteins derived from the genes encoding Clostridium difficile toxin A and toxin B, and their use in an active vaccine against C. difficile.
    Type: Application
    Filed: August 15, 2002
    Publication date: July 10, 2003
    Inventors: Tracy D. Wilkins, David M. Lyerly, J. Scott Moncrief, Limin Zheng, Carol Phelps
  • Membrane expression of heterologous genes
    Patent number: 5356797
    Abstract: The invention relates to nucleic acid segments useful in the construction of expression vectors for expression of heterologous polypeptides directed to particular areas of the host cell. Selected constructs direct production of polypeptides to the outer membrane surface of the cell. Other constructs direct expression of heterologous polypeptides to the inner membrane/periplasm of the host cell. Transformed host cells are potentially useful for the production of vaccines or immunogens elicited in response to antigens expressed on the outer membranes of the host cells.
    Type: Grant
    Filed: November 15, 1991
    Date of Patent: October 18, 1994
    Assignee: Board of Regents, The University of Texas
    Inventors: David W. Niesel, J. Scott Moncrief, Linda H. Phillips