Abstract: The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA).

Abstract: In some implementations, a first network device that hosts a bridge domain (BD) may receive inter-subnet multicast traffic associated with the BD. The BD may forward, using a supplemental bridge domain (SBD) interface of the first network device, and via an SBD, a first copy of the inter-subnet multicast traffic to a second network device that hosts the BD. The first network device may forward, using the SBD interface and via the SBD, a second copy of the inter-subnet multicast traffic to a third network device that does not host the BD. The first network device may forward, using an integrated routing and bridging (IRB) interface of the first network device associated with the BD, a third copy of the inter-subnet multicast traffic to a fourth network device that hosts the BD (e.g., when the fourth network device is a multihoming peer of the first network device).

Abstract: Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.

Abstract: The present disclosure provides a process for producing trifluoroiodomethane, the process comprising providing a reactant stream comprising hydrogen iodide and at least one trifluoroacetyl halide selected from the group consisting of trifluoroacetyl chloride, trifluoroacetyl fluoride, trifluoroacetyl bromide, and combinations thereof, reacting the reactant stream in the presence of a first catalyst at a first reaction temperature from about 25° C. to about 400° C. to produce an intermediate product stream comprising trifluoroacetyl iodide, and reacting the intermediate product stream in the presence of a second catalyst at a second reaction temperature from about 200° C. to about 600° C. to produce a final product stream comprising the trifluoroiodomethane.

Abstract: A method of assembling a vehicle component, a system for assembling a vehicle component, and a vehicle component assembly. A blank is formed from a steel sheet, wherein the steel sheet includes a coating on a surface. The coating is removed from a first interface surface of the blank and the blank is stamped either prior to or after removing the coating. The first dynamic interface surface is arranged relative to a second interface surface and thermally joined to form a joint.

Abstract: A method comprises acquiring anomaly data including a plurality of anomalies detected from streaming data, wherein each of the anomalies relates to an entity on or associated with a computer network. The method determines a risk score of each of the anomalies, and adjusts the risk score of an anomaly according to a set of factors. The method further determines, for each of a plurality of sliding time windows of different lengths, an entity score of the entity in relation to the sliding time window, based on an aggregation of risk scores of all anomalies related to the entity that were detected within the sliding time window, where the entity score corresponds to a risk level associated with the entity. An action to prevent the entity from performing an operation can be determined and caused to occur based on the entity score.

Abstract: Monitoring systems and methods for tracking movement of one or more animals in an enclosure, such as a fish tank, include introducing various stimuli, such as food, light, and auditory stimuli, and tracking the movement of the animals in response to these stimuli. Movement patterns of the animals can be determined and analyzed from data obtain from cameras that record images/videos of the relevant portions of the enclosure.

Abstract: A method using machine learned, scenario based control heuristics including: providing a simulation model for predicting a system state vector of the dynamical system in time based on a current scenario parameter vector and a control vector; using a Model Predictive Control, MPC, algorithm to provide the control vector during a simulation of the dynamical system using the simulation model for different scenario parameter vectors and initial system state vectors; calculating a scenario parameter vector and initial system state vector a resulting optimal control value by the MPC algorithm; generating machine learned control heuristics approximating the relationship between the corresponding scenario parameter vector and the initial system state vector for the resulting optimal control value using a machine learning algorithm; and using the generated machine learned control heuristics to control the complex dynamical system modelled by the simulation model.

Abstract: A rotor blade for a wind turbine is provided. The rotor blade includes a pressure side, a suction side, a leading edge section with a leading edge, and a trailing edge section with a trailing edge. An airflow flows along the surface of the rotor blade from the leading edge section to the trailing edge section and builds up a boundary layer in close proximity to the surface of the rotor blade. The rotor blade includes a noise reduction device for reducing noise which is generated by interaction of the airflow and the rotor blade. The noise reduction device is located within the boundary layer of the rotor blade. The noise reduction device includes a cover and connection device for connecting the cover to the surface of the rotor blade. The cover spans at least over a part of the surface of the rotor blade.

Abstract: A dynamic adjustable armrest includes a bracket supporting the armrest, a rod guide having a plurality of detents, the rod guide in slidable communication with the bracket, a locking rod engageable with the rod guide and the bracket. The locking rod is movable between at least a first position and a second position, and the armrest is movable between at least an up position and a down position.

Abstract: Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided.

Abstract: A dynamic adjustable armrest includes a bracket supporting the armrest, a rod guide having a plurality of detents, the rod guide in slidable communication with the bracket, a locking rod engageable with the rod guide and the bracket. The locking rod is movable between at least a first position and a second position, and the armrest is movable between at least an up position and a down position.

Abstract: Monitoring systems and methods for tracking movement of one or more animals in an enclosure, such as a fish tank, include introducing various stimuli, such as food, light, and auditory stimuli, and tracking the movement of the animals in response to these stimuli. Movement patterns of the animals can be determined and analyzed from data obtain from cameras that record images/videos of the relevant portions of the enclosure.

Abstract: Monitoring systems and methods for tracking movement of one or more animals in an enclosure, such as a fish tank, include introducing various stimuli, such as food, light, and auditory stimuli, and tracking the movement of the animals in response to these stimuli. Movement patterns of the animals can be determined and analyzed from data obtain from cameras that record images/videos of the relevant portions of the enclosure.

Abstract: Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided.

Abstract: A composite window film may include a first window facing substrate, a reflecting stack and an absorbing stack. The reflecting stack may be located between the first window facing substrate and the absorbing stack. The composite window film may have a VLT not greater than about 80%, a TSER of at least about 40%, and an Energetic Absorption (EA) of not greater than about 50%.

Abstract: A noise reducing wind turbine blade is disclosed. The wind turbine blade includes a blade body having a leading edge, a trailing edge, a suction side, and a pressure side. The wind turbine blade further includes a noise reducer disposed on a portion of the blade body extending partially upstream from the trailing edge for modifying airflow over the blade body effective to reduce acoustic emission.

Abstract: Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided.

Abstract: This document provides methods and materials involved in assessing intestinal permeability of a mammal. For example, methods and materials for administering 13C-mannitol to a mammal (e.g., a human) and determining urinary excretion of 13C-mannitol as a measure of intestinal permeability of a mammal are provided.

Abstract: A rotor blade for a wind turbine is provided, wherein the rotor blade includes serrations along at least a portion of the trailing edge section of the rotor blade. The serrations include a first tooth and at least a second tooth, and the first tooth is spaced apart from the second tooth. The area between the first tooth and the second tooth is at least partially filled with porous material such that generation of noise in the trailing edge section of the rotor blade is reduced. Furthermore, the embodiments relate to a wind turbine including at least one such a rotor blade.