Abstract: Various embodiments of a metered dose inhaler that includes a metering valve are disclosed. The inhaler includes a reservoir containing a pressurized formulation of medicament and carbon dioxide. The metering valve includes a metering chamber, a metering valve stem, and a metering valve stem seal having an opening through which the metering valve stem passes to form a dynamic seal between the metering valve stem and outside atmosphere. The metering valve stem seal has a Shore D hardness of 45 to 80 and its opening is adapted to be stretched wider by the metering valve stem passing through it than it would be absent the valve stem.

Abstract: Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have Essential Thrombocythemia (ET). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having ET.

Abstract: An actuator (100) for an inhaler includes a sleeve (106) having a first end (102) and a second end (104). The sleeve is substantially hollow and defines a longitudinal axis (110) along its length. A base (108) is formed at the first end of the sleeve. A mouthpiece (112) is joined to the sleeve and the base. The mouthpiece is substantially hollow and defines a delivery opening (114). The actuator includes a cover (116) removably attached to the mouthpiece for covering the delivery opening. The actuator further includes a retaining member for retaining the cover to the sleeve upon removal of the cover from the mouthpiece. The retaining member includes a ring (120) disposed around the sleeve. The ring is at least selectively rotatable about the longitudinal axis and slidable along the longitudinal axis relative to the sleeve. The retaining member further includes a strap (122) extending from the ring and attached to the cover.

Abstract: The present disclosure provides a method and a system to implement the method of using artificial intelligence to design security systems or plans for all manner of sites/locations, including high value government and commercial sites. In one embodiment, the method includes creating a digital twin (or copy) 10 of a site 20 and, using the digital twin 10, creating numerous permutations 30 of security systems 40 for the site 20 using security system design software 50 featuring artificial intelligence.

Abstract: This disclosure provides an apparatus, method, and non-transitory computer readable medium for operating networking for members and supporting a controlled-access establishment. The apparatus includes a memory and a processor couple to the memory. The memory stores a plurality of member profiles corresponding to a plurality of member devices including a first member profile corresponding to a first member device, where each member profile contains information about a member related to the member a member device.

Abstract: A flow governor for use in a medicinal inhaler. The flow governor can include (i) a tubular element that defines at least a portion of an air flow path, the tubular element comprising at least one flexible wall configured to flex inwardly in response to an air flow in the air flow path; and (ii) an internal support structure, located within the tubular element and configured to preserve at least a predetermined cross-sectional area of the air flow path within the tubular element when the at least one flexible wall of the tubular element flexes inwardly.

Abstract: A valved-container inhaler (150) has a mechanical return assembly with a spring (214) and a transfer (212) configured to transfer stored potential energy from the spring to a canister (51) and a clutch (208, 210) in a load path of the force between the spring and the transfer, the clutch being rotatable between a first condition in which load is transferred from the spring to the transfer, and a second condition in which the spring and the transfer can move relative to one another to interrupt the load path and thereby allow the canister to resile after actuation.

Abstract: A breath-responsive inhaler having a trigger mechanism for triggering delivery of a medicament to a user, the trigger mechanism including a medicament source, having a primed position in which the inhaler is primed for use and an actuated position in which the medicament source is actuated to dispense a dose of medicament, a toggle mechanism for selectively permitting movement of the source from its primed position to its actuated position, the toggle mechanism comprising a vane positioned in the air flow path, the vane being pivoted about a vane pivot, and wherein the trigger mechanism is triggered by movement of the vane upon inhalation of the user to move the toggle mechanism between a primed condition in which the medicament source is maintained in its primed position by cooperation with the toggle mechanism and an actuated condition in which the toggle mechanism is disengaged from cooperation with the medicament source.

Abstract: An inhaler having an air inlet, a medicament source, and an outlet for delivering an air and medicament admixture to a user, the inhaler including a primary power supply for powering the controller and a sensor for detecting a recent shake event, wherein, the sensor is independent of the primary power source and, in use, the sensor provides the controller with a signal indicative of any recent shake event upon the powering up of the controller prior to use of the inhaler.

Abstract: The present disclosure relates to a dose indicator for a pressure-actuated metered dose inhaler (pMDI) device. In an embodiment, the dose indicator comprises a chassis element having a viewing portion, a display element located within the chassis element, a resilient deformable element, and an indexing element having an axis, translation of the indexing element along its axis from a first position to a second position causing deformation of the resilient deformable element in the same direction as translation of the indexing element resulting in generally greater displacement of portions of the resilient deformable element nearer to the axis relative to portions thereof further from the axis, the displacement of the portions of the resilient deformable element in the same direction as translation of the indexing element inducing indexing of the display element from a current position to a subsequent position relative to the viewing portion of the chassis element.

Abstract: An apparatus includes at least one memory configured to store information identifying performances of multiple restaurants associated with an incubator project. The apparatus also includes at least one processor configured to correlate the performances of the restaurants over time to identify when one restaurant's performance is dependent upon one or more other restaurants' performances. The at least one processor could be configured to correlate the performances of the restaurants by correlating peak customer visits to the restaurants over time. The at least one processor could also be configured to correlate the peak customer visits to identify whether a specified one of the restaurants is visited more frequently when others of the restaurants are busier.

Abstract: An apparatus includes at least one memory configured to store information identifying performances of multiple restaurants associated with an incubator project. The apparatus also includes at least one processor configured to correlate the performances of the restaurants over time to identify when one restaurant's performance is dependent upon one or more other restaurants' performances. The at least one processor could be configured to correlate the performances of the restaurants by correlating peak customer visits to the restaurants over time. The at least one processor could also be configured to correlate the peak customer visits to identify whether a specified one of the restaurants is visited more frequently when others of the restaurants are busier.

Abstract: A dose indicator or dose counter is disclosed which includes an indexable first display unit indexable about a first display axis, an indexable second display unit indexable about a second display axis, the second display axis being transverse to the first display axis, and a chassis comprising a chassis frame, a displacement portion comprising a drive means to engage the first display unit, and at least one hinge means directly or indirectly connecting the displacement portion and chassis frame. The drive means is preferably configured to index the dose indicator. The dose indicator/counter has a small number of components yet is effective, reliable and compact.

Abstract: A dose indicator or dose counter is disclosed which includes an indexable first display unit indexable about a first display axis, an indexable second display unit indexable about a second display axis, the second display axis being transverse to the first display axis, and a chassis comprising a chassis frame, a displacement portion comprising a drive means to engage the first display unit, and at least one hinge means directly or indirectly connecting the displacement portion and chassis frame. The drive means is preferably configured to index the dose indicator. The dose indicator/counter has a small number of components yet is effective, reliable and compact.

Abstract: An actuator housing (100) for use with a metered dose inhaler (MDI) device which comprises a housing portion (115) having a nozzle block (130) in which an actuator seat (135) and an actuator nozzle (145) are formed. The housing portion has an axis (120) which is angled with respect to a vertical plane which is perpendicular to a base portion or thumb grip (150) formed at a closed end thereof. A mouthpiece portion (125) is joined to the housing portion which has a roof section (180) and a floor section (125b). The roof section is angled upwards with respect to the floor portion, and provides a cross-piece (185) with which teeth of a patient can engage. Such an actuator housing addresses problems associated with buccal and tongue deposition of medicaments, as a spray of medicament from the actuator nozzle is directed over the tongue and into the airway.

Abstract: Described herein is an actuator housing (500) for use with a metered dose inhaler (MDI) device which comprises a housing portion (115) having a nozzle block in which an actuator seat and an actuator nozzle are formed, and a mouthpiece portion (525) joined to the housing portion (115). The mouthpiece portion (525) has an external surface having a first or guidance region (570) over which teeth of a patient are to be located and a second or sealing region (580) against which lips of the patient seal during dispensing of a medicament. In one embodiment, the first or guidance region (570) comprises a plurality of longitudinally extending flutes arranged around the external surface and located adjacent to a mouthpiece end face (560). An optional annular projection (590) may be provided to define more precisely the sealing region for the patient.

Abstract: This disclosure provides an apparatus, method, and non-transitory computer readable medium for operating networking for members and supporting a controlled-access establishment. The apparatus includes a memory and a processor couple to the memory. The memory stores a plurality of member profiles corresponding to a plurality of member devices including a first member profile corresponding to a first member device, where each member profile contains information about a member related to the member a member device.

Abstract: Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have Essential Thrombocythemia (ET). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having ET.

Abstract: This disclosure provides an apparatus, method, and non-transitory computer readable medium for operating networking for members and supporting a controlled-access establishment. The apparatus includes a memory and a processor couple to the memory. The memory stores a plurality of member profiles corresponding to a plurality of member devices including a first member profile corresponding to a first member device, where each member profile contains information about a member related to the member a member device.