Abstract: An accommodating intraocular lens comprising a flexible body, a flexible optic which is moveable anteriorly and posteriorly relative to the lens body, and hinged portions longitudinally connecting the optic to the body. The body may have extending centration and fixation loops on its distal ends.

Abstract: A photoacoustic probe for port wine stain (PWS), burn and melanin depth measurements is comprised of optical fibers for laser light delivery and a piezoelectric element for acoustic detection. The probe induced and measured photoacoustic waves in acryl amide tissue phantoms and PWS skin in vivo. Acoustic waves were denoised using spline wavelet transforms, then deconvolved with the impulse response of the probe to yield initial subsurface pressure distributions in phantoms and skin. The waves were then analyzed for epidermal melanin concentration, using a photoacoustic melanin index (PAMI) related to the amount of laser energy absorbed by melanin. Propagation time of the photoacoustic wave was used to determine the depth of blood perfusion underlying necrotic, burned tissue. Thus, the photoacoustic probe can be used for determining PWS, burn and melanin depth for most patients receiving laser therapy.

Abstract: The present invention provides a surgical manipulator which is capable of manipulating a surgical or medical tool in up to six degrees of freedom. The manipulator has a haptic interface and an associated position sensing system. A controller is provided that can be used to adjust movement information from the haptic interface based on the relative orientations of the manipulator and the haptic interface.

Abstract: A support stand assembly for a rod and reel combination comprises a horizontal base member with a vertical support member extending from the base member. A linear support arm member is pivotally secured at a first end to the vertical support member, with the support arm member extending horizontally in a support position and pivoting upwardly to a release position. A stop member is secured adjacent a second end of the support arm member with a portion of the arm member extending beyond the stop member. An attachment member is adapted for securement to the rod of a rod and reel combination. The attachment member engages with the portion of the arm member extending beyond the stop member to support the rod and reel combination. In use, the attachment member is secured at the balance point of the rod and reel combination and engaged with the portion of the arm member extending beyond the stop member to support the rod and reel combination in a horizontal position.

Abstract: A drain seal for connecting a drain tube to a support structure includes a molded unitary body having first and second moldingly joined portions, each formed of dissimilar durometer materials. The first portion is formed to sealingly join the body to a drain tube. The second portion is formed to mount the body in an aperture in a support structure. A bore extends completely through the body.

Abstract: A support stand assembly for a rod and reel combination comprises a vertical support member, adapted for extending from a support surface. The support member includes a horizontal top surface and at least one vertical side surface. A T-shaped slot is positioned adjacent the at least one vertical surface of the support member and extends a selected distance into the support member from the top surface thereof. A leg of the T-shaped slot intersects the at least one vertical surface of the vertical support member. An attachment member is secured to the rod of a rod and reel combination proximal the balancing point thereof. The attachment member engages with the T-shaped slot of the support member to support the rod and reel combination in a horizontal position. The attachment member disengages from the T-shaped slot of the support member upon upward movement of the rod and reel combination.

Abstract: Instruments for performing percutaneous biopsy procedures are disclosed, which have advantageous features for improving functionality and performance over prior art devices. These instruments comprise two types, single-use devices, and multiple-use devices having active tissue capture capability. Improved features include the ability to retrieve and evaluate multiple tissue samples during a single insertion procedure, without physical handling of the samples, as well as constructional features, such as a molded tissue cassette housing, variant vacuum port embodiments suited for different tissue environments, and a method for backflushing the instrument to remove biological debris, among others.

Abstract: In optical coherence tomography (OCT), Axial and lateral resolutions are determined by the source coherence length and numerical aperture of the sampling lens, respectively. While axial resolution can be improved using a broadband light source, there is a trade-off between lateral resolution and focusing depth when conventional optical elements are used. The incorporation of an axicon lens into the sample arm of the interferometer overcomes this limitation. Using an axicon lens with a top angle of 160 degrees, 10 ?m or better-lateral resolution is maintained over a focusing depth of at least 6 mm. In addition to high lateral resolution, the focusing spot intensity is approximately constant over a greater depth range.

Abstract: An accommodating intraocular lens having anteriorly and posteriorly movable extended portions, such as T-shaped haptics, extending from a central optic to be implanted within a natural capsular bag of a human eye with the extended portions positioned between an anterior capsular rim and a posterior capsule of the bag, whereby during a post-operative healing period, fibrosis occurs about the extended portions to fixate the lens in the bag in a manner such that subsequent natural contraction and relaxation of the ciliary muscle moves the optic to provide vision accommodation of increased accommodation amplitude and diopters of accommodation.

Abstract: A phase-resolved functional optical coherence tomography system simultaneously obtains the Stokes vectors, structure, blood flow velocity, standard deviation, and birefringence images in human skin. The multifunctional images were obtained by processing the analytical interference fringe signals derived from the two perpendicular polarization detection channels. The blood flow velocity and standard deviation images were obtained by comparing the phase from the pairs of analytical signals in the neighboring A-lines in the same polarization state. The Stokes vectors were obtained by processing the analytical signals from two polarization diversity detection channels for the same reference polarization state. From the four Stokes vectors, the birefringence image, which is insensitive to the orientations of the optical axis in the sample, was obtained. Multifunctional images of a port wine stain birthmark in human skin are demonstrated.

Abstract: A nonrotating adjustable solar panel for optimizing cell charging of a portable message sign, comprising a movable frame, a message sign, a solar panel, a support post attached to the underside of the solar panel by a universal joint, and a mechanism for adjusting the angle and position of the solar panel comprising a pair of outwardly extending arms, a pair of threaded support rods, each rod extending through an aperture in the arm, and a handle for turning the rod. Each rod is coupled to the underside of the solar panel by a ball or universal joint. As each rod is turned, it raises or lowers a portion of the solar panel, providing tilting and pivoting, but not rotating motion for adjustment of the solar panel angle.

Abstract: The Doppler bandwidth extracted from the standard deviation of the frequency shift in phase-resolved optical Doppler tomography (ODT) is used to image the velocity component transverse to the probing beam. The effective numerical aperture (NA) of the optical objective determines the slope of the dependence of the standard deviation on velocity. In the case where the angle between the probing beam and flow direction is within ±15 degrees to the perpendicular, the Doppler frequency shift is very sensitive to angle position while the Doppler bandwidth is insensitive to flow direction. Linear dependence of the flow velocity on the Doppler bandwidth allows accurate measurement of flow velocity without precise determination of flow direction. In addition, it also extends the dynamic range of the average frequency shift mapping method used in the phase-resolved ODT.

Abstract: A disposable needleless injection device includes an integral unit that is dimensioned and arranged to be grasped in the hand of a user. The system is spring-loaded and is manufactured and shipped with the spring in a pre-cocked condition. An integral ampule is fillable by manipulation of a thrust rod/shaft which extends longitudinally through the device and is able to be grasped by a user. Once the unit is filled with a selected medication, it is held proximate the skin in order to inject the selected dosage. The unit is constructed from a maximum of eight component parts and is assembled in a matter of moments by unskilled personnel.

Abstract: An intraocular lens assembly for increased depth of focus has a frame configurated to vault posteriorly in an eye and an optic attached thereto. Pressure from ciliary muscle contraction moves the optic anteriorly to focus the eye for near vision.

Abstract: A flexible accommodating intraocular lens having anteriorly and posteriorly movable extended portions, such as T-shaped haptics, extending from a central solid biconvex optic to be implanted within a natural capsular bag of a human eye with the extended portions positioned between an anterior capsular rim and a posterior capsule of the bag, whereby during a post-operative healing period, fibrosis occurs about the extended portions to fixate the lens in the bag in a manner such that subsequent natural contraction and relaxation of the ciliary muscle moves the optic to provide vision accommodation. A surface of the optic is a toric surface.

Abstract: An intraocular lens provides substantially increased depth of focus for accurate near and far vision with an optic much thinner than a natural lens, and the lens being rigid vaulted posteriorly and adapted for posterior positioning in the capsular bag. The optic is positioned substantially farther from the cornea than a natural lens, so that a cone of light exiting the optic to impinge upon the retina is much smaller than a cone of light from a natural lens. Typically, the optic may be about 1.0 mm thick and its distance from the cornea 7.0-8.0 mm.

Abstract: An intraocular lens assembly for increased depth of focus has a frame configurated to vault posteriorly in an eye and an optic attached thereto. Pressure from ciliary muscle contraction moves the optic anteriorly to focus the eye for near vision.

Abstract: An insertion instrument provides improved features for insertion of a lens into the eye through a small incision. A tubular member has a lumen and a split nozzle end portion for spreading after insertion. Ridges on the lumen wall prevent rotation of the lens, and stabilizer components extend from a plunger end portion to maintain the lens compressed and to prevent lens rotation in moving through the lumen.

Abstract: A method and system of projecting light on a planar surface to produce an image for tracing is disclosed. The system includes a projector that has a light source and a signal conditioner that is operably connected to the projector. A computer is operably connected to the signal conditioner. A scanner is connected to the projector. A test pattern from the computer is projected from the projector through the scanners to visually align an image to a sector on a work surface. A grid is operably aligned with the work surface. A geometric pattern from the computer is then projected by the projector on the planar work surface for tracing. The method comprises the steps of creating a pattern, tracing lines along the pattern on the planar work surface, cutting the pattern along the traced lines, discarding pieces of the planar surface outside the pattern, and placing edging along an outer edge of the pattern.

Abstract: A photoacoustic probe for port wine stain (PWS), burn and melanin depth measurements is comprised of optical fibers for laser light delivery and a piezoelectric element for acoustic detection. The probe induced and measured photoacoustic waves in acryl amide tissue phantoms and PWS skin in vivo. Acoustic waves were denoised using spline wavelet transforms, then deconvolved with the impulse response of the probe to yield initial subsurface pressure distributions in phantoms and skin. The waves were then analyzed for epidermal melanin concentration, using a photoacoustic melanin index (PAMI) related to the amount of laser energy absorbed by melanin. Propagation time of the photoacoustic wave was used to determine the depth of blood perfusion underlying necrotic, burned tissue. Thus, the photoacoustic probe can be used for determining PWS, burn and melanin depth for most patients receiving laser therapy.