Abstract: Chimpanzee adenovirus (ChAd) and MVA virus vectors containing polynucleotide sequences encoding cancer antigens are administered sequentially to a subject in a suitable adjuvant in order to achieve a prime boost effect. The polynucleotides are expressed in situ following administration to provide a MAGEA3/linker/NY-ESO-1 fusion protein and variants thereof. Also, a hli/MAGEA3/linker/NY-ESO-1 fusion protein and variants thereof. An improved T cell response is found. In a particular synergistic therapeutic approach a triple combination of ChAdOx and MVA vectors together with chemotherapeutic agent and checkpoint inhibitor results in depleted myeloid derived suppressor cells (MDSC) and dramatically improves survival time in a mouse model of cancer.

Abstract: Procedure for the continuous manufacture of wall elements, characterized in that the different walls are effected continuously on a suitable transport system whereby these walls are assembled in vertical position on this transport system. The procedure includes at least the step of placing upper and lower beams; the connecting together of the extremities of these upper and lower beams placed behind each other without taking into consideration the length of the walls to be effected with regard to the length of these upper and lower beams; the installation of the windows and doors; the placing of the vertical posts; the placing of a first covering; the installation of electricity wires, sanitary pipes and utility pipes; the installation of insulating material; the installation of the second covering; the sawing out of the coverings at the location of the doors and/or windows; the sawing off to measure of the different walls.