Abstract: Described herein are methods and compositions for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.

Abstract: Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: Embodiments described herein relate to polyhdroxyalkanoate (PHA) copolymers and methods for their preparation utilizing ring-opening polymerization of lactones. Variations of the monomer composition, % of alternation, tacticity, and/or microstructure allow for tailoring of mechanical properties that fall into the elastomer, plastomer, and thermoplastic range.

Abstract: A method for controlling an illumination system includes detecting a first position of a marker in image data. In response to the first position, a first light target for the first light emission is identified. Controlling a light assembly to direct the first light emission to the first light target and maintaining the first light emission directed to the first light target. The method further includes detecting a second position of the marker in the image data. A second light target for the second light emission is identified in response to the second position. The light assembly is controlled to direct the second light emission to the second light target.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: Provided herein are EpCAM binding proteins, pharmaceutical compositions comprising such proteins or fragments thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such EpCAM binding proteins. Also disclosed are methods of using the disclosed EpCAM binding proteins in the prevention, and/or treatment diseases, conditions and disorders.

Abstract: Hydrogen-producing fuel processing systems and related methods. The systems include a hydrogen-producing region configured to produce a mixed gas stream from a feedstock stream, a hydrogen-separation membrane module having at least one hydrogen-selective membrane and configured to separate the mixed gas stream into a product hydrogen stream and a byproduct stream, and an oxidant delivery system configured to deliver an oxidant-containing stream to the hydrogen-separation membrane module in situ to increase hydrogen permeance of the hydrogen-selective membrane.

Abstract: A dual-beam optomechanical steerer includes first and second rotators mounted to a two-axis gimbal system. Each rotator is adjustable to control the azimuthal and elevation angles at which an optical transmitter affixed to the rotator transmits a beam of light. Thus, the two-axis gimbal system orients two optical transmitters identically while the first and second rotators orient the two optical transmitters independently with respect to the two-axis gimbal system. Examples of each rotator include a tip-tilt stage, goniometer, and rotation stage. Alternatively, a deflector may be used instead of each rotator. Examples of the deflector include an acousto-optic deflector, translatable lens, and Risley prism. The dual-beam steerer may be used to perform remote gas detection with two separate optical beams.

Abstract: A manhole lock system includes a frame positioned over an access opening, a cover movable between a closed position in which the cover extends over the access opening, and an open position in which the access opening is exposed; and a lock mechanism for locking the cover in the closed position. The lock mechanism includes a lock member that is movable along a path between a unlocked position and a locked position, wherein in the locked position the lock member prevents the cover from moving to the open position, wherein in the unlocked position the lock member is retracted to enable movement of the cover to the open position.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: Hydrogen-producing fuel processing systems and related methods. The systems include a hydrogen-producing region configured to produce a mixed gas stream from a feedstock stream, a hydrogen-separation membrane module having at least one hydrogen-selective membrane and configured to separate the mixed gas stream into a product hydrogen stream and a byproduct stream, and an oxidant delivery system configured to deliver an oxidant-containing stream to the hydrogen-separation membrane module in situ to increase hydrogen permeance of the hydrogen-selective membrane.

Abstract: Catalyst systems useful in ring-opening polymerization of ?-butyrolactone to produce syndiotactic PHB are provided. The catalyst systems include a ligand of the structural Formula I, Formula II, or Formula III and a Group 3 metal or metal precursor such as yttrium. The present catalyst systems are useful in adjusting syndiotacticity and thereby lowering the Tm of PHB for use in commercial applications.

Abstract: In some embodiments, the present disclosure provides a composition comprising 1) about 97.5 wt % to about 99.9 wt % of a first polyethylene having a density of about 0.91 g/cm3 to about 0.94 g/cm3, and a melt strength of about 10 mN or greater; and 2) about 0.1 wt % to about 2.5 wt % of a second polyethylene having an Mw of about 500,000 g/mol or more. In some embodiments, the composition is a film. In some embodiments, the present disclosure provides a method of making a composition comprising blending a first polyethylene of any embodiment described herein and a second polyethylene of any embodiment described herein.

Abstract: Various embodiments include network computing devices and methods for managing Domain Name Service (DNS) over Hypertext Transfer Protocol Secure (DoH). A processor of a network computing device may receive from a client computing device a DoH request comprising a public certificate associated with a client identifier. The processor may generate a fingerprint of the public certificate. The processor may obtain a client-specific DoH policy based on an association between the fingerprint of the public certificate and the client-specific DoH policy. The processor may apply the DoH policy to the DoH request to formulate a response to the DoH request.

Abstract: A system for processing powder includes a process tube connected to load lock chamber via a vacuum valve. The load lock chamber includes first and second stations. Each of the first and second stations is configured to receive a barrel containing powder to be treated. A mechanical transfer mechanism is configured to: move a barrel containing powder to be treated from the first station into the process tube; move a barrel containing powder to be treated from the second station into the process tube; move a barrel containing treated powder from the process tube to the first station; and move a barrel containing treated powder from the process tube to the second station.

Abstract: A method for characterizing gas emissions includes sampling each of a plurality of sectors having a common geographic center. For each sector, a first laser beam is transmitted from the geographic center to a first retroreflection location, where it is retroreflected into a first retroreflected beam. Near the geographic center, the first retroreflected beam is measured to obtain a first absorption. A second laser beam is then transmitted from the geographic center to a second retroreflection location, where it is retroreflected into a second retroreflected beam. Near the geographic center, the second retroreflected beam is measured to obtain a second absorption. The first and second retroreflection locations are both located within the same sector. First and second concentrations are determined from the first and second absorptions and processed to determine emission information about a known or potential gas source whose source lies within the sector.

Abstract: A fuel system, comprising at least one fuel component formed of a steel alloy comprising 0.01-0.31 wt. % carbon, 0.0-0.20 wt. % silicon, 0.15-0.50 wt. % manganese, 0.0-0.015 wt. % phosphorous, 0.0-0.001 wt. % sulfur, 4.80-5.20 wt. % chromium, 4.80-6.20 wt. % nickel, 0.60-0.80 wt. % molybdenum, 0.0-0.550 wt. % vanadium, and 2.000-2.400 wt. % aluminum, wherein the at least one fuel component is configured to come in contact with fuel when fuel is ran through the fuel system.