Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition.

Abstract: Collapsible structures are disclosed. In one embodiment, the collapsible structure includes a plurality of hinges and a plurality of panels. The plurality of panels are swingably connected by the plurality of hinges so as to form at least one arch when the collapsible structure is in an erected state and so as to become at least one stack of the plurality of panels in a collapsed state. The panels allow for the collapsible structure to maintain its structural integrity when erected but to have a compact and transportable configuration when collapsed.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: Systems, methods and apparatuses to log memory errors in memory devices that can perform wear leveling based on physical addresses used in the memory devices to address select memory cells. For example, a controller of a memory sub-system communicates with a memory device installed in the memory sub-system to access memory cells in the memory device. During the communication to access memory cells in the memory device, the controller can determine a memory error at a first address. If the controller transmits the first address to the memory device for memory access at the time of the memory error, the memory device converts the first address to a second address to perform the memory access. The controller can be configured to determine the second address and record, in an error log, the memory error in association with the second address.

Abstract: Described herein are methods and compositions for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.

Abstract: Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: Embodiments described herein relate to polyhdroxyalkanoate (PHA) copolymers and methods for their preparation utilizing ring-opening polymerization of lactones. Variations of the monomer composition, % of alternation, tacticity, and/or microstructure allow for tailoring of mechanical properties that fall into the elastomer, plastomer, and thermoplastic range.

Abstract: A method for controlling an illumination system includes detecting a first position of a marker in image data. In response to the first position, a first light target for the first light emission is identified. Controlling a light assembly to direct the first light emission to the first light target and maintaining the first light emission directed to the first light target. The method further includes detecting a second position of the marker in the image data. A second light target for the second light emission is identified in response to the second position. The light assembly is controlled to direct the second light emission to the second light target.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: Provided herein are EpCAM binding proteins, pharmaceutical compositions comprising such proteins or fragments thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such EpCAM binding proteins. Also disclosed are methods of using the disclosed EpCAM binding proteins in the prevention, and/or treatment diseases, conditions and disorders.

Abstract: Hydrogen-producing fuel processing systems and related methods. The systems include a hydrogen-producing region configured to produce a mixed gas stream from a feedstock stream, a hydrogen-separation membrane module having at least one hydrogen-selective membrane and configured to separate the mixed gas stream into a product hydrogen stream and a byproduct stream, and an oxidant delivery system configured to deliver an oxidant-containing stream to the hydrogen-separation membrane module in situ to increase hydrogen permeance of the hydrogen-selective membrane.

Abstract: A dual-beam optomechanical steerer includes first and second rotators mounted to a two-axis gimbal system. Each rotator is adjustable to control the azimuthal and elevation angles at which an optical transmitter affixed to the rotator transmits a beam of light. Thus, the two-axis gimbal system orients two optical transmitters identically while the first and second rotators orient the two optical transmitters independently with respect to the two-axis gimbal system. Examples of each rotator include a tip-tilt stage, goniometer, and rotation stage. Alternatively, a deflector may be used instead of each rotator. Examples of the deflector include an acousto-optic deflector, translatable lens, and Risley prism. The dual-beam steerer may be used to perform remote gas detection with two separate optical beams.

Abstract: A manhole lock system includes a frame positioned over an access opening, a cover movable between a closed position in which the cover extends over the access opening, and an open position in which the access opening is exposed; and a lock mechanism for locking the cover in the closed position. The lock mechanism includes a lock member that is movable along a path between a unlocked position and a locked position, wherein in the locked position the lock member prevents the cover from moving to the open position, wherein in the unlocked position the lock member is retracted to enable movement of the cover to the open position.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: Hydrogen-producing fuel processing systems and related methods. The systems include a hydrogen-producing region configured to produce a mixed gas stream from a feedstock stream, a hydrogen-separation membrane module having at least one hydrogen-selective membrane and configured to separate the mixed gas stream into a product hydrogen stream and a byproduct stream, and an oxidant delivery system configured to deliver an oxidant-containing stream to the hydrogen-separation membrane module in situ to increase hydrogen permeance of the hydrogen-selective membrane.

Abstract: Catalyst systems useful in ring-opening polymerization of ?-butyrolactone to produce syndiotactic PHB are provided. The catalyst systems include a ligand of the structural Formula I, Formula II, or Formula III and a Group 3 metal or metal precursor such as yttrium. The present catalyst systems are useful in adjusting syndiotacticity and thereby lowering the Tm of PHB for use in commercial applications.