Abstract: In one or more implementations of the present disclosure, a computer-implemented system and method are provided for virtually optimizing implant configurations to maximize range of motion in connection with total hip arthroplasty. At least one computing device receives preoperative clinical data of a patient and generates three-dimensional geometries of the patient's bones using the preoperative clinical data. Moreover, the at least one computing device selects implant geometry associated with at least one implant. Using the geometries of the bones and the selected at least one implant, the at least one computing device determines a virtual implantation including a plurality of components. The at least one computing device defines bounds in connection with the virtual implantation, including for at least one of component selection, position, orientation, and offset.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: A computerized system and method to assess joint level biomechanics and fixation level biomechanics of joint arthroplasty devices. At least one computing device, configured by executing instructions stored on non-transitory processor readable media receives preoperative medical information of a person requiring joint arthroplasty. Further, the at least one computing device determines, as a function of at least some of the preoperative medical information of the person, at least one of bony geometries, insertion, and origin of soft tissues respectively associated with the person. Furthermore, the at least one computing device accesses at least one musculoskeletal model including at least one of a bone, an implant, and soft tissue, wherein at least an aspect of the model includes a deformable body.

Abstract: Systems, methods and apparatuses to log memory errors in memory devices that can perform wear leveling based on physical addresses used in the memory devices to address select memory cells. For example, a controller of a memory sub-system communicates with a memory device installed in the memory sub-system to access memory cells in the memory device. During the communication to access memory cells in the memory device, the controller can determine a memory error at a first address. If the controller transmits the first address to the memory device for memory access at the time of the memory error, the memory device converts the first address to a second address to perform the memory access. The controller can be configured to determine the second address and record, in an error log, the memory error in association with the second address.

Abstract: Embodiments described herein relate to polyhdroxyalkanoate (PHA) copolymers and methods for their preparation utilizing ring-opening polymerization of lactones. Variations of the monomer composition, % of alternation, tacticity, and/or microstructure allow for tailoring of mechanical properties that fall into the elastomer, plastomer, and thermoplastic range.

Abstract: A method for controlling an illumination system includes detecting a first position of a marker in image data. In response to the first position, a first light target for the first light emission is identified. Controlling a light assembly to direct the first light emission to the first light target and maintaining the first light emission directed to the first light target. The method further includes detecting a second position of the marker in the image data. A second light target for the second light emission is identified in response to the second position. The light assembly is controlled to direct the second light emission to the second light target.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition.

Abstract: The present disclosure is directed, at least in part, to a self-testing detector device. The detector device may comprise: a chamber, a light source, a sensor, a substance emitter, and/or a speaker. The chamber may be configured to allow ambient air and substances to enter. The lights source may be configured to emit light into the chamber. In some embodiments, the sensor may be configured to detect light within the chamber. In other embodiments, the sensor may be configured to detect certain substances within the chamber directly. The substance emitter may be configured to emit substances during a test cycle of the detector device. The speaker may be configured to emit an audible alarm when the light or substances detected by the sensor pass a threshold.

Abstract: A fuel nozzle apparatus can include a nozzle that functions with two or more modes of operation with respect to a group of fuels, and an air shroud fixed over the nozzle. The air shroud blocks air through the nozzle or allows air through the nozzle in a predefined pattern. When a position of the air shroud is varied, the amount of the air and the location of the air into the nozzle is changed to facilitate the two or more modes of operation with respect to the group of fuels.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: A composition is provided to comprise a non-aqueous medium and a 3,4-oxypyridinone compound of structure (I): with each A being oxygen and/or sulfur, and with a variety of substituents at R1-R5 to enable a solution or an at least semi-stable emulsion to be formed in the non-aqueous medium. Methods of use are included herein, which may be focused on situations where the composition can be used as a lubricant and/or coolant.

Abstract: Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.

Abstract: A patient support system comprises a patient support apparatus for patients. The patient support apparatus comprises a base and a patient support surface supported by the base. The patient support apparatus also comprises side rails that move between raised and lowered positions. One or more actuators are coupled to each of the side rails. A controller communicates with the actuators to raise and lower the side rails, either without any manual assistance from the user, or with manual assistance from the user.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

Abstract: Systems and methods described herein provide deployment optimization service. A network device in a network receives an order for virtual network function (VNF) deployments at network edge locations. The network device maps a radio access network (RAN) topology for the network edge locations. The network device identifies time windows to perform the VNF deployments, based on the order, historical transport and RAN utilization data, and the RAN topology. The network device selects an optimal time window to perform the VNF deployments based on stored policy rules and pushes software images for the VNF deployments to an image repository in a geographical region near the network edge locations. The network device analyzes, for the optimal time window, real-time network data for a pre-emptive condition. The network device pre-empts the VNF deployments when a pre-emptive condition is identified and initiates the VNF deployments when no pre-emptive condition is identified.

Abstract: A machine comprising a rotor having: an inner member; an outer member encircling the inner member; and a groove in one of the inner member and the outer member. The groove has a first side wall, a second side wall and a base. A split ring seal is accommodated in the groove and contacts a surface of the other of the inner member and the outer member The first side wall has a plurality of open radial first channels and the second side wall has a plurality of open radial second channels.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.