Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition.

Abstract: A fuel nozzle apparatus can include a nozzle that functions with two or more modes of operation with respect to a group of fuels, and an air shroud fixed over the nozzle. The air shroud blocks air through the nozzle or allows air through the nozzle in a predefined pattern. When a position of the air shroud is varied, the amount of the air and the location of the air into the nozzle is changed to facilitate the two or more modes of operation with respect to the group of fuels.

Abstract: The present disclosure is directed, at least in part, to a self-testing detector device. The detector device may comprise: a chamber, a light source, a sensor, a substance emitter, and/or a speaker. The chamber may be configured to allow ambient air and substances to enter. The lights source may be configured to emit light into the chamber. In some embodiments, the sensor may be configured to detect light within the chamber. In other embodiments, the sensor may be configured to detect certain substances within the chamber directly. The substance emitter may be configured to emit substances during a test cycle of the detector device. The speaker may be configured to emit an audible alarm when the light or substances detected by the sensor pass a threshold.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: A composition is provided to comprise a non-aqueous medium and a 3,4-oxypyridinone compound of structure (I): with each A being oxygen and/or sulfur, and with a variety of substituents at R1-R5 to enable a solution or an at least semi-stable emulsion to be formed in the non-aqueous medium. Methods of use are included herein, which may be focused on situations where the composition can be used as a lubricant and/or coolant.

Abstract: Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.

Abstract: A patient support system comprises a patient support apparatus for patients. The patient support apparatus comprises a base and a patient support surface supported by the base. The patient support apparatus also comprises side rails that move between raised and lowered positions. One or more actuators are coupled to each of the side rails. A controller communicates with the actuators to raise and lower the side rails, either without any manual assistance from the user, or with manual assistance from the user.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

Abstract: Systems and methods described herein provide deployment optimization service. A network device in a network receives an order for virtual network function (VNF) deployments at network edge locations. The network device maps a radio access network (RAN) topology for the network edge locations. The network device identifies time windows to perform the VNF deployments, based on the order, historical transport and RAN utilization data, and the RAN topology. The network device selects an optimal time window to perform the VNF deployments based on stored policy rules and pushes software images for the VNF deployments to an image repository in a geographical region near the network edge locations. The network device analyzes, for the optimal time window, real-time network data for a pre-emptive condition. The network device pre-empts the VNF deployments when a pre-emptive condition is identified and initiates the VNF deployments when no pre-emptive condition is identified.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: A machine comprising a rotor having: an inner member; an outer member encircling the inner member; and a groove in one of the inner member and the outer member. The groove has a first side wall, a second side wall and a base. A split ring seal is accommodated in the groove and contacts a surface of the other of the inner member and the outer member The first side wall has a plurality of open radial first channels and the second side wall has a plurality of open radial second channels.

Abstract: Hydrogen-producing fuel processing systems and related methods. The systems include a hydrogen-producing region configured to produce a mixed gas stream from a feedstock stream, a hydrogen-separation membrane module having at least one hydrogen-selective membrane and configured to separate the mixed gas stream into a product hydrogen stream and a byproduct stream, and an oxidant delivery system configured to deliver an oxidant-containing stream to the hydrogen-separation membrane module in situ to increase hydrogen permeance of the hydrogen-selective membrane.

Abstract: Provided herein are EpCAM binding proteins, pharmaceutical compositions comprising such proteins or fragments thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such EpCAM binding proteins. Also disclosed are methods of using the disclosed EpCAM binding proteins in the prevention, and/or treatment diseases, conditions and disorders.

Abstract: A dual-beam optomechanical steerer includes first and second rotators mounted to a two-axis gimbal system. Each rotator is adjustable to control the azimuthal and elevation angles at which an optical transmitter affixed to the rotator transmits a beam of light. Thus, the two-axis gimbal system orients two optical transmitters identically while the first and second rotators orient the two optical transmitters independently with respect to the two-axis gimbal system. Examples of each rotator include a tip-tilt stage, goniometer, and rotation stage. Alternatively, a deflector may be used instead of each rotator. Examples of the deflector include an acousto-optic deflector, translatable lens, and Risley prism. The dual-beam steerer may be used to perform remote gas detection with two separate optical beams.

Abstract: A manhole lock system includes a frame positioned over an access opening, a cover movable between a closed position in which the cover extends over the access opening, and an open position in which the access opening is exposed; and a lock mechanism for locking the cover in the closed position. The lock mechanism includes a lock member that is movable along a path between a unlocked position and a locked position, wherein in the locked position the lock member prevents the cover from moving to the open position, wherein in the unlocked position the lock member is retracted to enable movement of the cover to the open position.

Abstract: A tufted article (e.g., an artificial turf panel) having a backing and a plurality of tufts extending through the backing. The plurality of tufts are distributed among a plurality of patterned regions. Each patterned region has at least one tuft of the plurality of tufts. The tufts of each patterned region differ from the tufts of at least one other patterned region of the tufted article in at least one of color, pile height, yarn type, or yarn density. At least one patterned region creates a longitudinal discontinuity in the color pattern of the tufted article. The tufted article does not have a seam. Complementary side edges of the tufted articles can be secured together to form at least a portion of the surface covering without the need for cutting or the use of inlay components.

Abstract: Hydrogen-producing fuel processing systems and related methods. The systems include a hydrogen-producing region configured to produce a mixed gas stream from a feedstock stream, a hydrogen-separation membrane module having at least one hydrogen-selective membrane and configured to separate the mixed gas stream into a product hydrogen stream and a byproduct stream, and an oxidant delivery system configured to deliver an oxidant-containing stream to the hydrogen-separation membrane module in situ to increase hydrogen permeance of the hydrogen-selective membrane.

Abstract: Catalyst systems useful in ring-opening polymerization of ?-butyrolactone to produce syndiotactic PHB are provided. The catalyst systems include a ligand of the structural Formula I, Formula II, or Formula III and a Group 3 metal or metal precursor such as yttrium. The present catalyst systems are useful in adjusting syndiotacticity and thereby lowering the Tm of PHB for use in commercial applications.

Abstract: In some embodiments, the present disclosure provides a composition comprising 1) about 97.5 wt % to about 99.9 wt % of a first polyethylene having a density of about 0.91 g/cm3 to about 0.94 g/cm3, and a melt strength of about 10 mN or greater; and 2) about 0.1 wt % to about 2.5 wt % of a second polyethylene having an Mw of about 500,000 g/mol or more. In some embodiments, the composition is a film. In some embodiments, the present disclosure provides a method of making a composition comprising blending a first polyethylene of any embodiment described herein and a second polyethylene of any embodiment described herein.