Patents by Inventor József Kardos

József Kardos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
    Patent number: 8173397
    Abstract: The invention relates to unglycosylated folded C-terminal fragments of a multidomain serine protease of the complement cascade obtainable by expression in a bacterial host, wherein said serine protease is capable of binding a recognition molecule of the complement cascade, e.g. C1 or MBL. The invention also relates to methods and bacterial expression vectors for the preparation of said fragments, uses of said fragments for raising antibodies and screening substrates or inhibitors of said serine proteases and uses of the fragments in research and treatment of complement related disorders. The invention also relates to assay methods for assessing MASP-1 and MASP-2 levels in a sample of biological origin. The invention provides for research tools, assays and diagnostic kits useful in complement research and research and diagnosis of complement related disorders.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: May 8, 2012
    Assignee: TargetEx Kft.
    Inventors: Péter Gál, Péter Závodszky, Géza Ambrus-Aikelin, József Kardos
  • Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
    Patent number: 7666627
    Abstract: The invention relates to unglycosylated folded C-terminal fragments of a multidomain serine protease of the complement cascade obtainable by expression in a bacterial host, wherein said serine protease is capable of binding a recognition molecule of the complement cascade, e.g. C1 or MBL. The invention also relates to methods and bacterial expression vectors for the preparation of said fragments, uses of said fragments for raising antibodies and screening substrates or inhibitors of said serine proteases and uses of the fragments in research and treatment of complement related disorders. The invention also relates to assay methods for assessing MASP-1 and MASP-2 levels in a sample of biological origin. The invention provides for research tools, assays and diagnostic kits useful in complement research and research and diagnosis of complement related disorders.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: February 23, 2010
    Assignee: TargetEx Kft.
    Inventors: Péter Gál, Péter Závodszky, Géza Ambrus-Aikelin, József Kardos
  • FOLDED RECOMBINANT CATALYTIC FRAGMENTS OF MULTIDOMAIN SERINE PROTEASES, PREPARATION AND USES THEREOF
    Publication number: 20090042248
    Abstract: The invention relates to unglycosylated folded C-terminal fragments of a multidomain serine protease of the complement cascade obtainable by expression in a bacterial host, wherein said serine protease is capable of binding a recognition molecule of the complement cascade, e.g. C1 or MBL. The invention also relates to methods and bacterial expression vectors for the preparation of said fragments, uses of said fragments for raising antibodies and screening substrates or inhibitors of said serine proteases and uses of the fragments in research and treatment of complement related disorders. The invention also relates to assay methods for assessing MASP-1 and MASP-2 levels in a sample of biological origin. The invention provides for research tools, assays and diagnostic kits useful in complement research and research and diagnosis of complement related disorders.
    Type: Application
    Filed: June 27, 2008
    Publication date: February 12, 2009
    Inventors: Peter Gal, Peter Zavodszky, Geza Ambrus-Aikelin, Jozsef Kardos
  • Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
    Publication number: 20050032157
    Abstract: The invention relates to unglycosylated folded C-terminal fragments of a multidomain serine protease of the complement cascade obtainable by expression in a bacterial host, wherein said serine protease is capable of binding a recognition molecule of the complement cascade, e.g. C1 or MBL. The invention also relates to methods and bacterial expression vectors for the preparation of said fragments, uses of said fragments for raising antibodies and screening substrates or inhibitors of said serine proteases and uses of the fragments in research and treatment of complement related disorders. The invention also relates to assay methods for assessing MASP-1 and MASP-2 levels in a sample of biological origin. The invention provides for research tools, assays and diagnostic kits useful in complement research and research and diagnosis of complement related disorders.
    Type: Application
    Filed: August 8, 2003
    Publication date: February 10, 2005
    Inventors: Peter Gal, Peter Zavodszky, Geza Ambrus-Aikelin, Jozsef Kardos