Patents by Inventor József Kozma

József Kozma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the production of polypeptides
    Patent number: 9416164
    Abstract: New methods for the production of recombinant polypeptides from inclusion bodies are disclosed. Modulation of the cell culture conditions positively affects the yield of the recombinant polypeptide in active form. In one aspect, the methods comprise (a) cultivating a host cell at a first temperature, the host cell comprising a nucleic acid encoding a recombinant polypeptide, (b) lowering the cultivation temperature from the first temperature to a second temperature, and (c) cultivating the host cell at the second temperature.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: August 16, 2016
    Assignee: Richter Gedeon Nyrt.
    Inventors: Ferenc Felföldi, Katalin Olasz, József Kozma
  • METHOD FOR THE PRODUCTION OF POLYPEPTIDES
    Publication number: 20150044721
    Abstract: New methods for the production of recombinant polypeptides from inclusion bodies are disclosed. Modulation of the cell culture conditions positively affects the yield of the recombinant polypeptide in active form. In one aspect, the methods comprise (a) cultivating a host cell at a first temperature, the host cell comprising a nucleic acid encoding a recombinant polypeptide, (b) lowering the cultivation temperature from the first temperature to a second temperature, and (c) cultivating the host cell at the second temperature.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 12, 2015
    Applicant: Rochter Gedeon Nyrt.
    Inventors: Ferenc Felföldi, Katalin Olasz, József Kozma
  • Isolated Isomers of Norelgestromin and Methods of Making and Using the Same
    Publication number: 20090312299
    Abstract: The invention is directed to a process of preparing substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.
    Type: Application
    Filed: July 9, 2009
    Publication date: December 17, 2009
    Inventors: Zoltán TUBA, Sándor MAHÓ, György KESERÜ, József KOZMA, János HORVÁTH, Gábor BALOGH
  • Process of making isomers of norelgestromin and methods using the same
    Patent number: 7576226
    Abstract: The invention is directed to a process of preparing substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: August 18, 2009
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zoltán Tuba, Sándor Mahó, György Keserü, József Kozma, János Horváth, Gábor Balogh
  • Process of making isomers of norelgestromin and methods using the same
    Publication number: 20050032764
    Abstract: The invention is directed to a process of preparing substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.
    Type: Application
    Filed: June 30, 2004
    Publication date: February 10, 2005
    Inventors: Zoltan Tuba, Sandor Maho, Gyorgy Keseru, Jozsef Kozma, Janos Horvath, Gabor Balogh