Patents by Inventor József Tímár

József Tímár has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FARNESYL-TRANSFERASE INHIBITORS AND KRAS INHIBITORS FOR TREATING KRAS MUTANT CANCERS
    Publication number: 20240058321
    Abstract: The invention relates to cancer biology, more specifically to the treatment of KRAS mutant cancers. A potent cancer therapy is provided by the combination of a farnesyl transferase inhibitor compound and a KRAS inhibitor compound.
    Type: Application
    Filed: November 2, 2022
    Publication date: February 22, 2024
    Inventors: József TÍMÁR, Balázs HEGEDUS, Marcell BARANYI, Eszter MOLNÁR, József TÓVÁRI, Ivan RANDELOVIC, András PERCZEL, György KESERU, László BUDAY
  • Intracellular targeting of molecules via syndecan-4
    Patent number: 8647828
    Abstract: The present invention provides methods for intracellular and/or nuclear targeting of an agent capable of specifically binding to syndecan-4. The present invention further provides methods for the modification of the intracellular and/or nuclear targeting of said agent, as well methods for identifying compounds capable of modifying the syndecan-4 delivery pathway. The present invention further provides experimental kits to perform the methods according to the invention.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: February 11, 2014
    Assignee: Szilak Laboratories Bioinformatics & Molecule-Design Ltd.
    Inventors: László Szilák, Anikó Keller-Pintér, József Tímár, Tamás Letoha
  • SYNDECAN-4 IS A REGULATOR OF RAC1-GTP
    Publication number: 20110124572
    Abstract: The present invention provides a method for modulating the activity of Rac1, comprising modifying the phosphorylation state of Ser179 in syndecan-4 through influencing the interaction between syndecan-4 and the guanin nucleotide exchange factor of Rac1 (RacGEF) named Tiam1 in a GTP-dependent manner. In particular, methods are provided for enhancing the epithelial phenotype of a cell and for initiating the polarization of a cell by increasing the de-phosphorylation of said Ser179 of syndecan-4, and for enhancing the migratory phenotype of a cell and for initiating the neuronal differentiation of a cell by increasing the phosphorylation of said Ser179 of syndecan-4. Polypeptides for use in modulating the activity of the small GTPase Rac are also provided, as well as a method for identifying an agent capable of indirectly modulating the activity of the small GTPase Rac 1.
    Type: Application
    Filed: July 24, 2009
    Publication date: May 26, 2011
    Inventors: László Szilák, Anikó Keller-Pintér, Tamás Letoha, József Tímár
  • INTRACELLULAR TARGETING OF MOLECULES
    Publication number: 20090305329
    Abstract: The present invention provides methods for intracellular and/or nuclear targeting of an agent capable of specifically binding to syndecan-4. The present invention further provides methods for the modification of the intracellular and/or nuclear targeting of said agent, as well methods for identifying compounds capable of modifying the syndecan-4 delivery pathway. The present invention further provides experimental kits to perform the methods according to the invention.
    Type: Application
    Filed: July 12, 2007
    Publication date: December 10, 2009
    Inventors: László Szilák, Anikó Keller-Pintér, József Tímár, Tamás Letoha