Patents by Inventor Jaacov Herzig

Jaacov Herzig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of podophyllotoxin derivatives
    Patent number: 4900814
    Abstract: There is provided a novel process for the production of the epipodophyllotoxin glycosides, Etoposide and Teniposide. There are further provided certain novel 4'-demethylepipodophyllotoxin derivatives of the following formula ##STR1## where W is hydrogen or 2,3-di-O-acetyl-4,6,O-ethylidene-D-glucopyran-1-yl. These intermediates are easily transformed into Etoposide and Teniposide and into further derivatives of this series.
    Type: Grant
    Filed: December 15, 1986
    Date of Patent: February 13, 1990
    Inventors: Jeffrey Sterling, Abraham Nudelman, Jaacov Herzig, Ehud Keinan, Ben Z. Weiner
  • Anomeric deacetylation
    Patent number: 4855417
    Abstract: There is provided a process for the selective anomeric deacetylation of sugar derivatives, which may be substituted by substituents such as acetoxy, chloracetoxy, alkoxy, azido, etc., by means of tin compounds R.sub.3 SnOR' or R.sub.2 SnO where R is lower alkyl resulting either directly in the desired anomeric compound or in an intermediate which is converted to the desired compound by silica or by acid hydrolysis.
    Type: Grant
    Filed: December 11, 1986
    Date of Patent: August 8, 1989
    Assignee: Yeda Research and Development Company Ltd
    Inventors: Abraham Nudelman, Jaacov Herzig, Ehud Keinan