Abstract: This invention provides a method a method of manufacturing a bed support for a chromatography column is disclosed. The method includes: placing the outer ring of the bed support on a support plate of a machine having a transitional stage; placing the mesh disk into the above ring, pressing another support plate on the mesh disk; rotating the transitional stage; providing a roller attached to the transitional stage with a certain force that is applied over the rim of the ring; and continuously applying the force of the roller onto the ring until a rim of the ring bends then assembles into the mesh disk.

Abstract: The invention provides the compounds of formula (): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.

Abstract: The invention relates to methods and devices for imaging a sample, in particular to methods and devices for imaging electrophoretic gels which have been used to separate biological molecules such as proteins or nucleic acids. The invention overcomes the problems associated with interference due to Newton's Rings and chemical toxicity experienced with conventional imaging systems.

Abstract: The present invention relates to a sealing assembly for use in chromatography columns and methods for forming a seal in such columns. The assembly comprises a sealing element composed of a material having a low coefficient of friction and a separate resilient member co-operating therewith. The seal provided is stable over a temperature range of +2° C. to +30° C.

Abstract: This invention provides a method a method of manufacturing a bed support for a chromatography column is disclosed. The method includes: placing the outer ring of the bed support on a support plate of a machine having a transitional stage; placing the mesh disk into the above ring, pressing another support plate on the mesh disk; rotating the transitional stage; providing a roller attached to the transitional stage with a certain force that is applied over the rim of the ring; and continuously applying the force of the roller onto the ring until a rim of the ring bends then assembles into the mesh disk.

Abstract: The present invention relates to a sealing assembly for use in chromatography columns and methods for forming a seal in such columns. The assembly comprises a sealing element composed of a material having a low coefficient of friction and a separate resilient member co-operating therewith. The seal provided is stable over a temperature range of +2° C. to +30° C.

Abstract: The invention relates to methods and devices for imaging a sample, in particular to methods and devices for imaging electrophoretic gels which have been used to separate biological molecules such as proteins or nucleic acids. The invention overcomes the problems associated with interference due to Newton's Rings and chemical toxicity experienced with conventional imaging systems.

Abstract: The invention provides the compounds of formula ( ): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.

Abstract: A time of flight spectrometer having a dynode detector in which a set of dynode plates at an output end of the dynode is each connected to an associated capacitor that functions as a charge reservoir for said dynode, thereby substantially avoiding saturating this dynode. A grid is place adjacent to and parallel to a front surface of a target to produce an acceleration region that accelerates ions substantially perpendicularly away from said front surface, thereby reducing time of flight deviations caused by nonperpendicular emission of ions from the target. A biased guide wire aligned perpendicular to the front surface of the target produces an electric field that images ions from the target onto a detector.