Patents by Inventor Jacek Capala

Jacek Capala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RADIOLABELED AFFIBODY MOLECULES
    Publication number: 20130004421
    Abstract: The invention provides a radiolabeled affibody molecule comprising a fragment of an IgG-binding domain of protein A from Staphylococcus aureus, a bifunctional linker, and a radiolabel comprising 18F or 76Br, wherein the bifunctional linker links the fragment and the radiolabel. The affibody molecule binds with high affinity to select receptors, which are over-expressed in certain cancers. Since the radionuclides emit a positron, the in vitro and in vivo binding characteristics of the radiolabeled affibody can be assessed using diagnostic imaging.
    Type: Application
    Filed: September 10, 2012
    Publication date: January 3, 2013
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health & Human Services
    Inventors: Jacek Capala, Dale O. Kiesewetter, Gabriela Kramer-Marek, Sang Bong Lee
  • Radiolabeled affibody molecules
    Patent number: 8303960
    Abstract: The invention provides a radiolabeled affibody molecule comprising a fragment of an IgG-binding domain of protein A from Staphylococcus aureus, a bifunctional linker, and a radiolabel comprising 18F or 76Br, wherein the bifunctional linker links the fragment and the radiolabel. The affibody molecule binds with high affinity to select receptors, which are over-expressed in certain cancers. Since the radionuclides emit a positron, the in vitro and in vivo binding characteristics of the radiolabeled affibody can be assessed using diagnostic imaging.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: November 6, 2012
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Jacek Capala, Dale O. Kiesewetter, Gabriela Kramer-Marek, Sang Bong Lee
  • RADIOLABELED AFFIBODY MOLECULES
    Publication number: 20100254899
    Abstract: The invention provides a radiolabeled affibody molecule comprising a fragment of an IgG-binding domain of protein A from Staphylococcus aureus, a bifunctional linker, and a radiolabel comprising 18F or 76Br, wherein the bifunctional linker links the fragment and the radiolabel. The affibody molecule binds with high affinity to select receptors, which are over-expressed in certain cancers. Since the radionuclides emit a positron, the in vitro and in vivo binding characteristics of the radiolabeled affibody can be assessed using diagnostic imaging.
    Type: Application
    Filed: February 27, 2008
    Publication date: October 7, 2010
    Applicant: The United States of America, as represented by the Secretary, Dept of Health and Human Services
    Inventors: Jacek Capala, Dale O. Kiesewetter, Gabriela Kramer-Marek, Sang Bong Lee