Patents by Inventor Jacek Gaertig

Jacek Gaertig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALPHA-TUBULIN ACETYLTRANSFERASE
    Publication number: 20140248635
    Abstract: Polypeptides with tubulin acetyltransferase activity are described, as are nucleic acids encoding said polypeptides, and methods of use. The invention further provides enhancers and inhibitors of tubulin acetyltransferase activity, as well as cells having altered tubulin transferase activity.
    Type: Application
    Filed: February 4, 2014
    Publication date: September 4, 2014
    Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Jacek Gaertig, Dorota Wloga, Shilpa Akella
  • Biological system and assay for identifying modulators of tubulin ligases
    Patent number: 8361780
    Abstract: Tetrahymena is used as a host cell in a biological assay for identification of modulators of tubulin ligases.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: January 29, 2013
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Jacek Gaertig, Dorota Wloga, Swati M. Suryavanshi
  • Biological system and assay for identifying modulators of tubulin ligases
    Publication number: 20100261220
    Abstract: Tetrahymena is used as a host cell in a biological assay for identification of modulators of tubulin ligases.
    Type: Application
    Filed: February 5, 2010
    Publication date: October 14, 2010
    Inventors: Jacek Gaertig, Dorota Wloga, Swati M. Suryavanshi
  • Recombinant expression of heterologous nucleic acids in protozoa
    Patent number: 7326568
    Abstract: The ciliated protozoan Tetrahymena exemplifies a recombinant system for the expression of heterologous nucleic acids, preferably on the plasma membrane surface. Integration of a heterlogous nucleic acid into the ?-tubulin gene, BTU1, of a paclitaxel-sensitive T. thermophila mutant that possesses btu1-IK350M ?-tubulin allele allows screening for transformants using negative selection, as transformants have restored paclitaxel resistance. Transgenic ciliated protozoa of the invention can serve as live vaccines. For example, transgenic Tetrahymena expressing Ichthyophthirius multifiliis i-antigen protein on their surface are effective vehicles for vaccination of freshwater fish against infection by I. multifiliis.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: February 5, 2008
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Jacek Gaertig, Donna Cassidy-Hanley
  • Biological system and assay for identifying inhibitors of tubulin glutamylases
    Publication number: 20070031927
    Abstract: Tetrahymena is used as a host cell in a biological assay for identification of inhibitors of tubulin glutamylases.
    Type: Application
    Filed: June 30, 2006
    Publication date: February 8, 2007
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Jacek Gaertig, Dorota Wloga, Krzysztof Rogowski
  • Recombinant expression of heterologous nucleic acids in protozoa
    Publication number: 20050106164
    Abstract: The ciliated protozoan Tetrahymena exemplifies a recombinant system for the expression of heterologous nucleic acids, preferably on the plasma membrane surface. Integration of a heterlogous nucleic acid into the ?-tubulin gene, BTU1, of a paclitaxel-sensitive T. thermophila mutant that possesses btu1-IK350M ?-tubulin allele allows screening for transformants using negative selection, as transformants have restored paclitaxel resistance. Transgenic ciliated protozoa of the invention can serve as live vaccines. For example, transgenic Tetrahymena expressing Ichthyophthirius multifiliis i-antigen protein on their surface are effective vehicles for vaccination of freshwater fish against infection by I. multifiliis.
    Type: Application
    Filed: June 28, 2004
    Publication date: May 19, 2005
    Inventors: Jacek Gaertig, Harry Dickerson, Theodore Clark, Donna Cassidy-Hanley
  • Recombinant expression of heterologous nucleic acids in protozoa
    Patent number: 6846481
    Abstract: The ciliated protozoan Tetrahymena exemplifies a recombinant system for the expression of heterologous nucleic acids, preferably on the plasma membrane surface. Integration of a heterlogous nucleic acid into the ?-tubulin gene, BTU1, of a paclitaxel-sensitive T. thermophila mutant that possesses btu1-1K350M ?-tubulin allele allows screening for transformants using negative selection, as transformants have restored paclitaxel resistance. Transgenic ciliated protozoa of the invention can serve as live vaccines. For example, transgenic Tetrahymena expressing Ichthyophthirius multifiliis i-antigen protein on their surface are effective vehicles for vaccination of freshwater fish against infection by I. multifiliis.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: January 25, 2005
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Jacek Gaertig, Harry W. Dickerson, Jr., Theodore G. Clark