Patents by Inventor Jacek Grodner

Jacek Grodner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of 1,3,2-oxazaphosphorinanes
    Patent number: 4908464
    Abstract: Process for production of derivatives of 1,3,2-oxazaphosphorinane of general formula 1, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atom or 2-halogenoalkyl group, and R.sub.1 and R.sub.2 are not at the same time hydrogen atoms, and X represents halogen atom is based, according to the invention, on the reduction of the respective 3-halogenoacyl derivatives of 1,3,2-oxazaphosphorinane of general formula 2, ##STR2## wherein the substituents have the above given meaning. The reduction is accomplished with the use of sodium borohydride in the presence of boron trifluoride etherate.Derivatives that are prepared by the procedure described here demonstrate antitumor activity.
    Type: Grant
    Filed: June 9, 1988
    Date of Patent: March 13, 1990
    Assignees: Instytut Przemyslu Farmaceutycznego, Centrum Baden Molekularnych i Makromolekularnych -PAN, Instytut Immunologii i Terapii Doswiadczalnej -PAN
    Inventors: Wojciech J. Stec, Czeslaw Radzikowski, Wieslaw Szelejewski, Ryszard Kinas, Konrad Misiura, Grzegorz Grynkiewicz, Jacek Grodner, Halina Kusnierczyk, Andrzej Kutner, Slawomira Pilichowska