Abstract: The invention provides a method for evaluating a set of input data, the input data comprising at least one of: clinical data of a subject; genomic data of a subject; clinical data of a plurality of subjects; and genomic data of a plurality of subjects, using a deep learning algorithm. The method includes obtaining a set of input data, wherein the set of input data comprises raw data arranged into a plurality of data clusters and tuning the deep learning algorithm based on the plurality of data clusters. The deep learning algorithm comprises: an input layer; an output layer; and a plurality of hidden layers. The method further includes performing statistical clustering on the raw data using the deep learning algorithm, thereby generating statistical clusters and obtaining a marker from each statistical cluster. Finally, the set of input data is evaluated based on the markers to derive data of medical relevance in respect of the subject or subjects.

Abstract: The invention provides a method for evaluating a set of input data, the input data comprising at least one of: clinical data of a subject; genomic data of a subject; clinical data of a plurality of subjects; and genomic data of a plurality of subjects, using a deep learning algorithm. The method includes obtaining a set of input data, wherein the set of input data comprises raw data arranged into a plurality of data clusters and tuning the deep learning algorithm based on the plurality of data clusters. The deep learning algorithm comprises: an input layer; an output layer; and a plurality of hidden layers. The method further includes performing statistical clustering on the raw data using the deep learning algorithm, thereby generating statistical clusters and obtaining a marker from each statistical cluster. Finally, the set of input data is evaluated based on the markers to derive data of medical relevance in respect of the subject or subjects.

Abstract: The present invention relates to an ultrasound imaging system (100) for producing spatially compounded 3D ultrasound image data, comprising: —an ultrasound acquisition unit (16) for acquiring a plurality of 3D ultrasound image data having different but at least partially overlapping field of views, —a tracking unit (62) adapted to determine a relative spatial position of each of the plurality of 3D ultrasound image data with respect to each other, and —a stitching unit (64) adapted to compound the plurality of 3D ultrasound image data by stitching them to each other in order to generate compounded 3D ultrasound image data, wherein the stitching unit (64) is adapted to calculate a stitching order of the plurality of 3D ultrasound image data based on the determined relative spatial position of the 3D ultrasound image data by minimizing an overlapping area of the different field of views of the plurality of 3D ultrasound image data, and wherein stitching unit (64) is adapted to stitch the plurality of 3D ultraso

Abstract: An ultrasound probe positioning system comprises a positioning unit for holding an ultrasound probe unit and for moving the ultrasound probe unit and positioning it at a target position and a positioning control unit configured to provide target positioning data indicative of a target position that establishes a mechanical contact of the ultrasound probe unit with an external object and to control the mechanical positioning unit in moving and positioning the ultrasound probe at the target position. The positioning unit comprises a force actuation unit configured to adapt a pressing force amount of a mechanical pressing force exerted on the object in response to a variation of a counterforce amount so as to maintain a predetermined net pressing force amount exerted by the mechanical pressing force against the counterforce.

Abstract: A method of clustering or grouping subjects that are similar to one another. A dataset contains, for each subject, a set of quantitative values which each represent a respective clinical or pathological feature of that subject. A principal component analysis, PCA, is performed on the dataset. Loadings of one of the first two principal components identified by the PCA are used to generate a respective dataset of weighting values. These weighting values are used to weigh or modify each set of quantitative values in the dataset. A clustering algorithm is performed on the weighted sets of subject data. The process may be iterated until user-defined stopping conditions are satisfied.

Abstract: An ultrasound probe positioning system (100) comprises a positioning unit (102) for holding an ultrasound probe unit (104) and for moving the ultrasound probe unit and positioning it at a target position and a positioning control unit (106) configured to provide target positioning data indicative of a target position that establishes a mechanical contact of the ultrasound probe unit with an external object (110) and to control the mechanical positioning unit in moving and positioning the ultrasound probe at the target position. The positioning unit comprises a force actuation unit (108) configured to adapt a pressing force amount of a mechanical pressing force exerted on the object in response to a variation of a counterforce amount so as to maintain a predetermined net pressing force amount exerted by the mechanical pressing force against the counterforce.

Abstract: A system and computer-implemented method are provided for generating a visualization of the classification uncertainty of a classification model which is applied to clinical data, wherein said visualization is provided in a lower-dimensional space which is obtained by applying a non-linear and manifold preserving dimensionality reduction technique to feature vectors of the clinical data. The visualization techniques consider the classification model as a ‘black box’ by not being dependent on internal parameters of the classification model.

Abstract: The invention relates to a system and method for tracking at least one anatomic structure by means of an image-registration based tracking procedure using at least one parameter, where the anatomic structure includes a plurality of implanted markers. A parameter setting (6, 7) unit is configured to determine measured positions of the implanted markers in each image of a series of images acquired using an imaging unit (1), and to perform an optimization procedure to determine an optimized value of the at least one parameter on the basis of deviations between the measured and calculated positions. Then, the position of the anatomic structure is tracked in further images by means of the tracking procedure using the optimized value of the at least one parameter.

Abstract: There is provided an apparatus and a method of operating the apparatus for providing feedback to a participant directing a communication to one or more other participants. The apparatus (100) comprises a processor (102) configured to acquire, from one or more physiological characteristic sensors (104), one or more physiological characteristic signals from at least one participant to which the communication is directed as the communication is received by the at least one participant. The processor (102) is also configured to determine a measure of the quality of the communication based on a comparison of the one or more physiological characteristic signals acquired from the at least one participant with one or more expected physiological characteristic signals and control a user interface (108) to provide feedback of the determined quality measure of the communication to the participant directing the communication to the at least one participant.

Abstract: A device (10) configured to detect the presence of metal artifacts in a patient's eye includes a head mount (14) configured to receive at least a portion of the patient's head. At least one inductor coil (12) is disposed on or in the head mount and positioned to inductively couple with at least one eye of the patient's head received into the head mount. An inductance meter (18) is operably connected to the at least one inductor coil to measure an inductance as a change of frequency of the at least one inductor coil. A processor (22) is programmed to: determine whether the inductance is greater than an inductance threshold value; and generate an indication of at least one metal artifact when the inductance is greater than the inductance threshold value. A display component (24) is configured to display the indication.

Abstract: A computerized system (SRS) for radiation therapy support. The system comprises an input interface (IN) for receiving an input image acquired by an imaging apparatus (IA1). The input image represents a region of interest (ROI) internal of a patient (PAT) and acquired before delivery of a dose fraction by a radiation therapy delivery apparatus (RTD). A pre-trained machine learning unit (MLU) of the system is configured to process the input image to detect a medical condition. A communication component (RC) of the system is configured to provide, based on the detected medical condition, an indication for one or more clinical actions to be performed in relation to the patient.

Abstract: It is an object of the present invention to provide a system allowing to provide improved template treatment parameters for ablation treatment allowing an optimized ablation treatment. A system for assisting in providing template treatment parameters is presented. The system comprises a treatment parameter providing unit (101) providing treatment parameters, a patient data providing unit (102) providing technical patient outcome data and/or clinical patient outcome data, a template treatment parameter determining unit (104) for determining template treatment parameters based on a relation between any of the treatment parameters, the technical patient outcome data and/or the clinical patient outcome data. Thus, the template treatment parameters can be optimized in accordance with the technical and/or clinical outcome of the treatment applied using the treatment parameters.

Abstract: An ultrasound probe positioning system (100) comprises a positioning unit (102) for holding an ultrasound probe unit (104) and for moving the ultrasound probe unit and positioning it at a target position and a positioning control unit (106) configured to provide target positioning data indicative of a target position that establishes a mechanical contact of the ultrasound probe unit with an external object (110) and to control the mechanical positioning unit in moving and positioning the ultrasound probe at the target position. The positioning unit comprises a force actuation unit (108) configured to adapt a pressing force amount of a mechanical pressing force exerted on the object in response to a variation of a counterforce amount so as to maintain a predetermined net pressing force amount exerted by the mechanical pressing force against the counterforce.

Abstract: A system and a method for medical therapy, particularly ablation treatment, are provided in which diagnostic data may be processed and represented as a function of therapy time. This allows to appropriate plan and dynamically monitor thermal ablation therapy which significantly reduces the risks to damage organs and tissue outside the target area.

Abstract: It is an object of the invention to provide for a system that can be used to improve a cancer related clinical workflow compared to the current cancer related clinical workflow. This object is achieved by an image guided system configured for supporting a combined biopsy and treatment procedure using image guidance to bring a needle from a defined location to a predetermined end location in a subject of interest. The image guidance system comprises a medical imaging system configured for acquisition of medical images of a region of interest in the subject of interest, wherein the medical images are used to determine a current position of the predetermined end location. The image guidance system further comprises needle guidance system configured for defining a needle position in space and thereby defining the defined location and configured for guiding a biopsy and treatment needle into the region of interest.

Abstract: The invention relates to a therapy planning device for planning a therapy to be applied to tissue of a subject (2). A tissue parameter distribution, which has been generated based on a magnetic resonance fingerprint scan of the tissue, and a therapy goal distribution, which defines a distribution of at least one parameter being indicative of a desired effect of the therapy, are provided. A machine learning module (13), which has been trained to output at least one therapy application parameter defining the application of the therapy based on an input tissue parameter distribution and an input therapy goal distribution, is used for planning the therapy by determining the at least one therapy application parameter based on the provided tissue parameter distribution and the provided therapy goal distribution. This allows for a consideration of the actual quantitative tissue parameter distriution of the patient, thereby improving planning quality.

Abstract: The present disclosure pertains to a system for providing model-based predictions of quality of life implications of a treatment via individual-specific machine learning models. In some embodiments, the system (i) obtains social media information related to an individuals social media activities, the individual awaiting prescription of a predetermined treatment; (ii) performs one or more queries to obtain health and social media information associated with similar individuals having (a) similar social media activities and (b) a record of receiving the predetermined treatment; (iii) provides the health and social media information associated with the similar individuals to a machine learning model to train the machine learning model; and (iv) provides the social media information associated with the individual to the machine learning model to predict (a) a likelihood of the one or more health states and (b) an estimated importance of each of the one or more health states for the individual.

Abstract: It is an object of the invention to provide for a system that can be used to improve a cancer related clinical workflow compared to the current cancer related clinical workflow. This object is achieved by an image guided system configured for supporting a combined biopsy and treatment procedure using image guidance to bring a needle from a defined location to a predetermined end location in a subject of interest. The image guidance system comprises a medical imaging system (580) configured for acquisition of medical images of a region of interest (403) in the subject of interest, wherein the medical images are used to determine a current position of the predetermined end location (404). The image guidance system further comprises needle guidance system (402, 403) configured for defining a needle position in space and thereby defining the defined location (405, 406) and configured for guiding a biopsy and treatment needle into the region of interest.

Abstract: The invention relates to a system for assisting a user in positioning a thermal ablation device (1) on the basis of a planned ablation position. The system comprises an evaluation unit (6) adapted to (i) compute an optimized thermal dose distribution deliverable to the treatment region by means of the device (1) operating at a current position thereof, (ii) determine a path for steering the device (1) from the current position to the planned position and to assign a cost to the determined path, the cost quantifying estimated detrimental effects of steering the device (1) along the computed path, and (iii) present information about the optimized thermal dose distribution and about the cost assigned to the computed path to the user.

Abstract: A patch pocket folding apparatus (1) comprises: a template (2), moving means (3) of the template (2), a folding body (4), against which the template (2) pushes a fabric (T), folding blades (5), a folding unit (G) disposed under the folding body (4); the folding unit (G) is composed of a set of strips (6) made of an easily workable rigid material that are fixed under the folding body (4) and define an internal corresponding border having the same profile as the external border of the template (2).